The role of signaling crosstalk of microglia in hippocampus on progression of ageing and Alzheimer's disease

The role of signaling crosstalk of microglia in hippocampus on progression of ageing and Alzheimer's disease

Based on single-cell sequencing of the hippocampi of 5× familiar Alzheimer's disease (5× FAD) and wild type mice at 2-, 12-, and 24-month of age, we found an increased percentage of microglia in aging and Alzheimer's disease (AD) mice. Blood brain barrier injury may also have contributed t...

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Bibliographic Details
Main Authors:	He Li, Tianyuan Ye, Xingyang Liu, Rui Guo, Xiuzhao Yang, Yangyi Li, Dongmei Qi, Yihua Wei, Yifan Zhu, Lei Wen, Xiaorui Cheng
Format:	Article
Language:	English
Published:	Elsevier 2023-07-01
Series:	Journal of Pharmaceutical Analysis
Subjects:	Alzheimer's disease Microglia Immune Crosstalk Chemokine Colony-stimulating factor
Online Access:	http://www.sciencedirect.com/science/article/pii/S2095177923000965

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