A novel visceral adiposity index predicts bone loss in female early rheumatoid arthritis patients detected by HR-pQCT
Abstract The purpose of this prospective study is to compare the Chinese visceral adiposity index (CVAI) between early rheumatoid arthritis (ERA) patients and healthy controls; and to assess the relationship between CVAI and the bone microstructure using high-resolution peripheral quantitative compu...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-29505-z |
| _version_ | 1811165910175580160 |
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| author | Jiang Yue Priscilla C. H. Wong Ying Zhang Feng Peng James F. Griffith Jiankun Xu Fan Xiao Tena K. Li Vivian Hung Ling Qin Lai-Shan Tam |
| author_facet | Jiang Yue Priscilla C. H. Wong Ying Zhang Feng Peng James F. Griffith Jiankun Xu Fan Xiao Tena K. Li Vivian Hung Ling Qin Lai-Shan Tam |
| author_sort | Jiang Yue |
| collection | DOAJ |
| description | Abstract The purpose of this prospective study is to compare the Chinese visceral adiposity index (CVAI) between early rheumatoid arthritis (ERA) patients and healthy controls; and to assess the relationship between CVAI and the bone microstructure using high-resolution peripheral quantitative computed tomography (HR-pQCT) in ERA patients. 104 female ERA and 100 age-, gender- and BMI-matched healthy controls were recruited for the comparison of CVAI. All ERA patients were prospectively followed for 1 year. HR-pQCT scan of the distal radius, tibia and second metacarpal head were performed at baseline and after one-year. ERA patients were divided into two sub-groups according to the median CVAI value (65.73) (low CVAI and high CVAI groups). CVAI in the ERA group was significantly higher than the controls group (p = 0.01). At baseline, the high CVAI group had a higher ESR level (p = 0.004) while the cortical volumetric bone mineral density (vBMD) was lower (at both the distal radius and tibia, all p < 0.05) compared to the low CVAI group. Linear regression analysis revealed that a higher baseline CVAI was an independent predictor of a lower cortical vBMD at month 12 (distal radius: B = − 0.626, p = 0.022, 95%CI − 1.914 to − 0.153; tibia: B = − 0.394, p = 0.003, 95%CI − 1.366 to − 0.290); and a greater reduction in trabecular vBMD (tibia: B = 0.444, p = 0.001, 95%CI 0.018–0.063; distal radius: B = 0.356, p = 0.008, 95%CI 0.403–0.063). In summary, CVAI is an independent predictor of trabecular bone loss in female patients with ERA, which may be augmented by a chronic inflammatory state in patients with visceral dysfunction of fat metabolism. Trial registration: http://Clinicaltrial.gov no: NCT01768923, 16/01/2013. |
| first_indexed | 2024-04-10T15:43:52Z |
| format | Article |
| id | doaj.art-1c67842d5d364a16b0741f1be1ccf439 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T15:43:52Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-1c67842d5d364a16b0741f1be1ccf4392023-02-12T12:11:15ZengNature PortfolioScientific Reports2045-23222023-02-011311910.1038/s41598-023-29505-zA novel visceral adiposity index predicts bone loss in female early rheumatoid arthritis patients detected by HR-pQCTJiang Yue0Priscilla C. H. Wong1Ying Zhang2Feng Peng3James F. Griffith4Jiankun Xu5Fan Xiao6Tena K. Li7Vivian Hung8Ling Qin9Lai-Shan Tam10Department of Endocrinology and Metabolism, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong KongDepartment of Laboratory Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Laboratory Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Imaging and Interventional Radiology, The Prince of Wales Hospital, The Chinese University of Hong KongBone Quality and Health Center, Department of Orthopedics & Traumatology, The Prince of Wales Hospital, The Chinese University of Hong KongDepartment of Imaging and Interventional Radiology, The Prince of Wales Hospital, The Chinese University of Hong KongDepartment of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong KongBone Quality and Health Center, Department of Orthopedics & Traumatology, The Prince of Wales Hospital, The Chinese University of Hong KongBone Quality and Health Center, Department of Orthopedics & Traumatology, The Prince of Wales Hospital, The Chinese University of Hong KongDepartment of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong KongAbstract The purpose of this prospective study is to compare the Chinese visceral adiposity index (CVAI) between early rheumatoid arthritis (ERA) patients and healthy controls; and to assess the relationship between CVAI and the bone microstructure using high-resolution peripheral quantitative computed tomography (HR-pQCT) in ERA patients. 104 female ERA and 100 age-, gender- and BMI-matched healthy controls were recruited for the comparison of CVAI. All ERA patients were prospectively followed for 1 year. HR-pQCT scan of the distal radius, tibia and second metacarpal head were performed at baseline and after one-year. ERA patients were divided into two sub-groups according to the median CVAI value (65.73) (low CVAI and high CVAI groups). CVAI in the ERA group was significantly higher than the controls group (p = 0.01). At baseline, the high CVAI group had a higher ESR level (p = 0.004) while the cortical volumetric bone mineral density (vBMD) was lower (at both the distal radius and tibia, all p < 0.05) compared to the low CVAI group. Linear regression analysis revealed that a higher baseline CVAI was an independent predictor of a lower cortical vBMD at month 12 (distal radius: B = − 0.626, p = 0.022, 95%CI − 1.914 to − 0.153; tibia: B = − 0.394, p = 0.003, 95%CI − 1.366 to − 0.290); and a greater reduction in trabecular vBMD (tibia: B = 0.444, p = 0.001, 95%CI 0.018–0.063; distal radius: B = 0.356, p = 0.008, 95%CI 0.403–0.063). In summary, CVAI is an independent predictor of trabecular bone loss in female patients with ERA, which may be augmented by a chronic inflammatory state in patients with visceral dysfunction of fat metabolism. Trial registration: http://Clinicaltrial.gov no: NCT01768923, 16/01/2013.https://doi.org/10.1038/s41598-023-29505-z |
| spellingShingle | Jiang Yue Priscilla C. H. Wong Ying Zhang Feng Peng James F. Griffith Jiankun Xu Fan Xiao Tena K. Li Vivian Hung Ling Qin Lai-Shan Tam A novel visceral adiposity index predicts bone loss in female early rheumatoid arthritis patients detected by HR-pQCT Scientific Reports |
| title | A novel visceral adiposity index predicts bone loss in female early rheumatoid arthritis patients detected by HR-pQCT |
| title_full | A novel visceral adiposity index predicts bone loss in female early rheumatoid arthritis patients detected by HR-pQCT |
| title_fullStr | A novel visceral adiposity index predicts bone loss in female early rheumatoid arthritis patients detected by HR-pQCT |
| title_full_unstemmed | A novel visceral adiposity index predicts bone loss in female early rheumatoid arthritis patients detected by HR-pQCT |
| title_short | A novel visceral adiposity index predicts bone loss in female early rheumatoid arthritis patients detected by HR-pQCT |
| title_sort | novel visceral adiposity index predicts bone loss in female early rheumatoid arthritis patients detected by hr pqct |
| url | https://doi.org/10.1038/s41598-023-29505-z |
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