Can pretreatment hepatic artery perfusion scintigraphy in patients with liver malignancies predict the treatment response of the selective internal radiation therapy with 90Y resin microspheres?
PURPOSEWe aimed to evaluate whether the perfusion pattern from pretreatment hepatic artery perfusion scintigraphy (HAPS) in patients with liver malignancies can predict response to selective internal radiation therapy (SIRT).METHODSThis retrospective study analyzed 152 consecutive patients treated w...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2022-03-01
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| Series: | Diagnostic and Interventional Radiology |
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http://www.dirjournal.org/archives/archive-detail/article-preview/can-pretreatment-hepatic-artery-perfusion-scintigr/53740
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| _version_ | 1797691337205612544 |
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| author | Isa Burak Guney Huseyin Tugsan Balli Kadir Alper Kucuker Ilker Unal Mustafa Kibar |
| author_facet | Isa Burak Guney Huseyin Tugsan Balli Kadir Alper Kucuker Ilker Unal Mustafa Kibar |
| author_sort | Isa Burak Guney |
| collection | DOAJ |
| description | PURPOSEWe aimed to evaluate whether the perfusion pattern from pretreatment hepatic artery perfusion scintigraphy (HAPS) in patients with liver malignancies can predict response to selective internal radiation therapy (SIRT).METHODSThis retrospective study analyzed 152 consecutive patients treated with yttrium-90 (90Y) resin microspheres between April 2015 and July 2017. HAPS using single-photon emission computed tomography/computed tomography (SPECT/CT) with 99mtechnetium macroaggregated albumin (99mTc-MAA) was performed before SIRT. Investigators visually classified perfusion patterns of tumors as heterogeneous or diffuse in HAPS. Between diffuse and heterogeneous pattern group, positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI) were performed in third and sixth month after SIRT, and tumor response assessed and compared by using RECIST 1.1 or mRECIST. Overall survival (OS) and progression-free survival (PFS) were also compared with Kaplan-Meier/log-rank analyses.RESULTSOf 216 SIRT procedures, 172 were classified as heterogeneous and 44 as diffuse. Diffuse 99mTc- MAA uptake was associated with longer median OS than heterogeneous (22.2 vs. 14.4 months, respectively; P = .047). Subsegmental infusion was associated with longer OS than either lobar or segmental infusion (P = .090). Mean estimated OS was longer in patients with hepatocellular carcinoma (HCC) (34.2 months) than with colorectal carcinoma (CRC) (16.4 months) (P = .044). Patients with both diffuse and heterogeneous patterns were able to show complete response after SIRT. No statistically significant differences were observed between perfusion patterns and PFS or response rates to SIRT.CONCLUSIONAlthough tumor perfusion patterns from preplanning HAPS analyses are useful for estimating tumor uptake of 90Y, they may not reliably predict hepatic treatment response, as patients with different perfusion patterns can show clinical response to SIRT. |
| first_indexed | 2024-03-12T02:12:53Z |
| format | Article |
| id | doaj.art-1c67f3ae479f4c0da9fa3f8289ff43bc |
| institution | Directory Open Access Journal |
| issn | 1305-3825 1305-3612 |
| language | English |
| last_indexed | 2024-03-12T02:12:53Z |
| publishDate | 2022-03-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Diagnostic and Interventional Radiology |
| spelling | doaj.art-1c67f3ae479f4c0da9fa3f8289ff43bc2023-09-06T12:10:32ZengGalenos Publishing HouseDiagnostic and Interventional Radiology1305-38251305-36122022-03-0128215616510.5152/dir.2022.2077513049054Can pretreatment hepatic artery perfusion scintigraphy in patients with liver malignancies predict the treatment response of the selective internal radiation therapy with 90Y resin microspheres?Isa Burak Guney0Huseyin Tugsan Balli1Kadir Alper Kucuker2Ilker Unal3Mustafa Kibar4 Department of Nuclear Medicine, Faculty of Medicine, Cukurova University, Adana, Turkey Department of Radiology, Faculty of Medicine, Cukurova University, Adana, Turkey Department of Nuclear Medicine, Faculty of Medicine, Cukurova University, Adana, Turkey Department of Biostatistics, Faculty of Medicine, Cukurova University, Adana, Turkey Department of Nuclear Medicine, Faculty of Medicine, Cukurova University, Adana, Turkey PURPOSEWe aimed to evaluate whether the perfusion pattern from pretreatment hepatic artery perfusion scintigraphy (HAPS) in patients with liver malignancies can predict response to selective internal radiation therapy (SIRT).METHODSThis retrospective study analyzed 152 consecutive patients treated with yttrium-90 (90Y) resin microspheres between April 2015 and July 2017. HAPS using single-photon emission computed tomography/computed tomography (SPECT/CT) with 99mtechnetium macroaggregated albumin (99mTc-MAA) was performed before SIRT. Investigators visually classified perfusion patterns of tumors as heterogeneous or diffuse in HAPS. Between diffuse and heterogeneous pattern group, positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI) were performed in third and sixth month after SIRT, and tumor response assessed and compared by using RECIST 1.1 or mRECIST. Overall survival (OS) and progression-free survival (PFS) were also compared with Kaplan-Meier/log-rank analyses.RESULTSOf 216 SIRT procedures, 172 were classified as heterogeneous and 44 as diffuse. Diffuse 99mTc- MAA uptake was associated with longer median OS than heterogeneous (22.2 vs. 14.4 months, respectively; P = .047). Subsegmental infusion was associated with longer OS than either lobar or segmental infusion (P = .090). Mean estimated OS was longer in patients with hepatocellular carcinoma (HCC) (34.2 months) than with colorectal carcinoma (CRC) (16.4 months) (P = .044). Patients with both diffuse and heterogeneous patterns were able to show complete response after SIRT. No statistically significant differences were observed between perfusion patterns and PFS or response rates to SIRT.CONCLUSIONAlthough tumor perfusion patterns from preplanning HAPS analyses are useful for estimating tumor uptake of 90Y, they may not reliably predict hepatic treatment response, as patients with different perfusion patterns can show clinical response to SIRT. http://www.dirjournal.org/archives/archive-detail/article-preview/can-pretreatment-hepatic-artery-perfusion-scintigr/53740 |
| spellingShingle | Isa Burak Guney Huseyin Tugsan Balli Kadir Alper Kucuker Ilker Unal Mustafa Kibar Can pretreatment hepatic artery perfusion scintigraphy in patients with liver malignancies predict the treatment response of the selective internal radiation therapy with 90Y resin microspheres? Diagnostic and Interventional Radiology |
| title | Can pretreatment hepatic artery perfusion scintigraphy in patients with liver malignancies predict the treatment response of the selective internal radiation therapy with 90Y resin microspheres? |
| title_full | Can pretreatment hepatic artery perfusion scintigraphy in patients with liver malignancies predict the treatment response of the selective internal radiation therapy with 90Y resin microspheres? |
| title_fullStr | Can pretreatment hepatic artery perfusion scintigraphy in patients with liver malignancies predict the treatment response of the selective internal radiation therapy with 90Y resin microspheres? |
| title_full_unstemmed | Can pretreatment hepatic artery perfusion scintigraphy in patients with liver malignancies predict the treatment response of the selective internal radiation therapy with 90Y resin microspheres? |
| title_short | Can pretreatment hepatic artery perfusion scintigraphy in patients with liver malignancies predict the treatment response of the selective internal radiation therapy with 90Y resin microspheres? |
| title_sort | can pretreatment hepatic artery perfusion scintigraphy in patients with liver malignancies predict the treatment response of the selective internal radiation therapy with 90y resin microspheres |
| url |
http://www.dirjournal.org/archives/archive-detail/article-preview/can-pretreatment-hepatic-artery-perfusion-scintigr/53740
|
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