Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity

Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity

The Transient Receptor Potential Vanilloid 1 (TRPV) channel is activated by an array of stimuli, including heat and vanilloid compounds. The TRPV1 homologues TRPV2 and TRPV3 are also activated by heat, but sensitivity to vanilloids and many other agonists is not conserved among TRPV subfamily member...

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Bibliographic Details
Main Authors: Feng Zhang, Kenton Jon Swartz, Andres Jara-Oseguera
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
TRP channel
TRPV
ion channel gating
vanilloid
resiniferaroxin
Online Access:https://elifesciences.org/articles/42756

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