Importance of OGTT for diagnosis of Diabetes in thalassemia major patients
Background and Objective: Thalassemia major is a genetic disorder. Blood transfusion is critical for survival in these patients. Over the course of the past two and three decade’s hyper transfusion therapy in these patients has increased significant improvement in life expectancy and quality of life...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Golestan University of Medical Sciences
2008-10-01
|
| Series: | مجله دانشگاه علوم پزشکی گرگان |
| Subjects: | |
| Online Access: | http://goums.ac.ir/journal/browse.php?a_code=A-10-1-320&slc_lang=en&sid=1 |
| _version_ | 1818145588443611136 |
|---|---|
| author | Farzad Najafipour (MD) Roohangiz Sari Sorkhabi (MD) Navideh Haji Aghai (GP) Masoomeh Zareizadeh (MD) Amir Bahrami (MD) |
| author_facet | Farzad Najafipour (MD) Roohangiz Sari Sorkhabi (MD) Navideh Haji Aghai (GP) Masoomeh Zareizadeh (MD) Amir Bahrami (MD) |
| author_sort | Farzad Najafipour (MD) |
| collection | DOAJ |
| description | Background and Objective: Thalassemia major is a genetic disorder. Blood transfusion is critical for survival in these patients. Over the course of the past two and three decade’s hyper transfusion therapy in these patients has increased significant improvement in life expectancy and quality of life. Unfortunately this type of therapy increased the frequency of complication due to iron overloud. The aim of this study was to evaluate the prevalencey of diabetes, impaired fasting glucose and impaired glucose tolerance in patients with thalassemia major, with 10-27 years of age in Tabriz. Materials and Methods: This descriptive study was done on 56 patients between 10-27 years of age with thalassemia major. The demographic informaiton theraputic regiment, the age of first trasfussion. The level of blood transfusion, the history and dosage of familial history of diabetes, Fe, TIBC, ferritin levels were assessed and recorded. For each patient glucose tolerance test, blood glucose level are performed. Results: In this study prevalence of diabetes mellitus, impaired fasting glucose and impaired glucose tolerance test were found in 8.9%, 28.6% and 7.1% of patients respectively. Conclusion: This study showed that despite recent therapy with Desferal in the management of beta-thalassemia major, the risk of secondary endocrine dysfunction remains high. Prevalence of diabetes mellitus, impaired fasting glucose and impaired glucose tolerance test are greater than general population. Endocrine evaluation in patients with thalassemia major must be carried out regularly especially in those patients over the age of 10 years. |
| first_indexed | 2024-12-11T12:05:51Z |
| format | Article |
| id | doaj.art-1c6851132bf24a66a9c09ebb4e074558 |
| institution | Directory Open Access Journal |
| issn | 1562-4765 2008-4080 |
| language | fas |
| last_indexed | 2024-12-11T12:05:51Z |
| publishDate | 2008-10-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی گرگان |
| spelling | doaj.art-1c6851132bf24a66a9c09ebb4e0745582022-12-22T01:07:56ZfasGolestan University of Medical Sciencesمجله دانشگاه علوم پزشکی گرگان1562-47652008-40802008-10-011037176Importance of OGTT for diagnosis of Diabetes in thalassemia major patientsFarzad Najafipour (MD)0Roohangiz Sari Sorkhabi (MD)1Navideh Haji Aghai (GP)2Masoomeh Zareizadeh (MD)3Amir Bahrami (MD)4 Background and Objective: Thalassemia major is a genetic disorder. Blood transfusion is critical for survival in these patients. Over the course of the past two and three decade’s hyper transfusion therapy in these patients has increased significant improvement in life expectancy and quality of life. Unfortunately this type of therapy increased the frequency of complication due to iron overloud. The aim of this study was to evaluate the prevalencey of diabetes, impaired fasting glucose and impaired glucose tolerance in patients with thalassemia major, with 10-27 years of age in Tabriz. Materials and Methods: This descriptive study was done on 56 patients between 10-27 years of age with thalassemia major. The demographic informaiton theraputic regiment, the age of first trasfussion. The level of blood transfusion, the history and dosage of familial history of diabetes, Fe, TIBC, ferritin levels were assessed and recorded. For each patient glucose tolerance test, blood glucose level are performed. Results: In this study prevalence of diabetes mellitus, impaired fasting glucose and impaired glucose tolerance test were found in 8.9%, 28.6% and 7.1% of patients respectively. Conclusion: This study showed that despite recent therapy with Desferal in the management of beta-thalassemia major, the risk of secondary endocrine dysfunction remains high. Prevalence of diabetes mellitus, impaired fasting glucose and impaired glucose tolerance test are greater than general population. Endocrine evaluation in patients with thalassemia major must be carried out regularly especially in those patients over the age of 10 years.http://goums.ac.ir/journal/browse.php?a_code=A-10-1-320&slc_lang=en&sid=1Thalassemia MajorDiabetes MellitusImpaired Glucose ToleranceImpaired Fasting Glucose |
| spellingShingle | Farzad Najafipour (MD) Roohangiz Sari Sorkhabi (MD) Navideh Haji Aghai (GP) Masoomeh Zareizadeh (MD) Amir Bahrami (MD) Importance of OGTT for diagnosis of Diabetes in thalassemia major patients مجله دانشگاه علوم پزشکی گرگان Thalassemia Major Diabetes Mellitus Impaired Glucose Tolerance Impaired Fasting Glucose |
| title | Importance of OGTT for diagnosis of Diabetes in thalassemia major patients |
| title_full | Importance of OGTT for diagnosis of Diabetes in thalassemia major patients |
| title_fullStr | Importance of OGTT for diagnosis of Diabetes in thalassemia major patients |
| title_full_unstemmed | Importance of OGTT for diagnosis of Diabetes in thalassemia major patients |
| title_short | Importance of OGTT for diagnosis of Diabetes in thalassemia major patients |
| title_sort | importance of ogtt for diagnosis of diabetes in thalassemia major patients |
| topic | Thalassemia Major Diabetes Mellitus Impaired Glucose Tolerance Impaired Fasting Glucose |
| url | http://goums.ac.ir/journal/browse.php?a_code=A-10-1-320&slc_lang=en&sid=1 |
| work_keys_str_mv | AT farzadnajafipourmd importanceofogttfordiagnosisofdiabetesinthalassemiamajorpatients AT roohangizsarisorkhabimd importanceofogttfordiagnosisofdiabetesinthalassemiamajorpatients AT navidehhajiaghaigp importanceofogttfordiagnosisofdiabetesinthalassemiamajorpatients AT masoomehzareizadehmd importanceofogttfordiagnosisofdiabetesinthalassemiamajorpatients AT amirbahramimd importanceofogttfordiagnosisofdiabetesinthalassemiamajorpatients |