SERUM VISFATIN RELATIONSHIP WITH GLYCEMIC CONTROL AND ADIPOSITY INDICES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
OBJECTIVE: To assess and compare serum visfatin levels with body composition adiposity indices and glycemic control in patients with Type 2 Diabetes Mellitus (T2DM). METHODS: This observational case-control study was conducted at the Department of Physiology, College of Medicine and King Khalid U...
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| Format: | Article |
| Language: | English |
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Khyber Medical University
2020-12-01
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| Series: | Khyber Medical University Journal |
| Subjects: | |
| Online Access: | https://www.kmuj.kmu.edu.pk/article/view/20254 |
| _version_ | 1797807292707504128 |
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| author | Syed Shahid Habib Shahid Bashir Syed Hamid Habib |
| author_facet | Syed Shahid Habib Shahid Bashir Syed Hamid Habib |
| author_sort | Syed Shahid Habib |
| collection | DOAJ |
| description | OBJECTIVE: To assess and compare serum visfatin levels with body composition adiposity indices and glycemic control in patients with Type 2 Diabetes Mellitus (T2DM).
METHODS: This observational case-control study was conducted at the Department of Physiology, College of Medicine and King Khalid University Hospital (KKUH), Riyadh, Saudi Arabia from April 2018 to March 2019. We studied sixty three individuals (33 T2DM and 30 controls) who were recruited from diabetes care clinics. Anthropometric, demographic and clinical characteristics were recorded from all participants and they were matched for age and gender. Venous blood samples were collected to measure visfatin and glycosylated hemoglobin (HbA1c). Adiposity indices were analyzed by Bio Impedance Analyzer (BIA).
RESULTS: Serum visfatin levels were 7.01±3.79 ng/ml in subjects with T2DM and 4.02±2.74 ng/ml in healthy subjects (p=0.046). Body composition indices including BMI, BMR, body fat percentage [BF%], body fat mass [BFM], truncal fat [TF], truncal fat mass [TFM] and visceral fat [VF] differences were not statistically significant between two groups. Serum visfatin levels were 9.29±3.44 ng/ml in T2DM with poor glycemic control (HbA1c >7.5%) as compared to 4.24±1.87 ng/ml in diabetic patients with good glycemic control (HbA1c <7.5%) [p=0.001]. Visfatin positively correlated with BMI (r=0.284, p<0.05), BF% (r=0.302, p<0.05), BFM (r=0.280, p<0.05), VF (r=0.263, p<0.05) and HbA1c (r=0.394, p<0.01).
CONCLUSION: The results of this study show that T2DM patients have high serum visfatin levels. Moreover, higher levels of visfatin are observed with poor glycemic control and increasing body adiposity indices. |
| first_indexed | 2024-03-13T06:20:23Z |
| format | Article |
| id | doaj.art-1c69c66a85cb4468a02008b98fa6101f |
| institution | Directory Open Access Journal |
| issn | 2305-2643 2305-2651 |
| language | English |
| last_indexed | 2024-03-13T06:20:23Z |
| publishDate | 2020-12-01 |
| publisher | Khyber Medical University |
| record_format | Article |
| series | Khyber Medical University Journal |
| spelling | doaj.art-1c69c66a85cb4468a02008b98fa6101f2023-06-09T19:10:57ZengKhyber Medical UniversityKhyber Medical University Journal2305-26432305-26512020-12-01124263710.35845/kmuj.2020.202541314SERUM VISFATIN RELATIONSHIP WITH GLYCEMIC CONTROL AND ADIPOSITY INDICES IN PATIENTS WITH TYPE 2 DIABETES MELLITUSSyed Shahid Habib0Shahid Bashir1Syed Hamid Habib2Department of Physiology, College of Medicine & King Khalid University Hospital, King Saud University, Riyadh, Kingdom of Saudi ArabiaNeuroscience Centre, King Fahad Specialist Hospital Dammam, Kingdom of Saudi ArabiaDepartment of Physiology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, PakistanOBJECTIVE: To assess and compare serum visfatin levels with body composition adiposity indices and glycemic control in patients with Type 2 Diabetes Mellitus (T2DM). METHODS: This observational case-control study was conducted at the Department of Physiology, College of Medicine and King Khalid University Hospital (KKUH), Riyadh, Saudi Arabia from April 2018 to March 2019. We studied sixty three individuals (33 T2DM and 30 controls) who were recruited from diabetes care clinics. Anthropometric, demographic and clinical characteristics were recorded from all participants and they were matched for age and gender. Venous blood samples were collected to measure visfatin and glycosylated hemoglobin (HbA1c). Adiposity indices were analyzed by Bio Impedance Analyzer (BIA). RESULTS: Serum visfatin levels were 7.01±3.79 ng/ml in subjects with T2DM and 4.02±2.74 ng/ml in healthy subjects (p=0.046). Body composition indices including BMI, BMR, body fat percentage [BF%], body fat mass [BFM], truncal fat [TF], truncal fat mass [TFM] and visceral fat [VF] differences were not statistically significant between two groups. Serum visfatin levels were 9.29±3.44 ng/ml in T2DM with poor glycemic control (HbA1c >7.5%) as compared to 4.24±1.87 ng/ml in diabetic patients with good glycemic control (HbA1c <7.5%) [p=0.001]. Visfatin positively correlated with BMI (r=0.284, p<0.05), BF% (r=0.302, p<0.05), BFM (r=0.280, p<0.05), VF (r=0.263, p<0.05) and HbA1c (r=0.394, p<0.01). CONCLUSION: The results of this study show that T2DM patients have high serum visfatin levels. Moreover, higher levels of visfatin are observed with poor glycemic control and increasing body adiposity indices.https://www.kmuj.kmu.edu.pk/article/view/20254diabetes mellitus type 2visfatinnicotinamide phosphoribosyltransferaseglycemic controlbody fat percentageintra-abdominal fatvisceral fat |
| spellingShingle | Syed Shahid Habib Shahid Bashir Syed Hamid Habib SERUM VISFATIN RELATIONSHIP WITH GLYCEMIC CONTROL AND ADIPOSITY INDICES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS Khyber Medical University Journal diabetes mellitus type 2 visfatin nicotinamide phosphoribosyltransferase glycemic control body fat percentage intra-abdominal fat visceral fat |
| title | SERUM VISFATIN RELATIONSHIP WITH GLYCEMIC CONTROL AND ADIPOSITY INDICES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS |
| title_full | SERUM VISFATIN RELATIONSHIP WITH GLYCEMIC CONTROL AND ADIPOSITY INDICES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS |
| title_fullStr | SERUM VISFATIN RELATIONSHIP WITH GLYCEMIC CONTROL AND ADIPOSITY INDICES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS |
| title_full_unstemmed | SERUM VISFATIN RELATIONSHIP WITH GLYCEMIC CONTROL AND ADIPOSITY INDICES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS |
| title_short | SERUM VISFATIN RELATIONSHIP WITH GLYCEMIC CONTROL AND ADIPOSITY INDICES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS |
| title_sort | serum visfatin relationship with glycemic control and adiposity indices in patients with type 2 diabetes mellitus |
| topic | diabetes mellitus type 2 visfatin nicotinamide phosphoribosyltransferase glycemic control body fat percentage intra-abdominal fat visceral fat |
| url | https://www.kmuj.kmu.edu.pk/article/view/20254 |
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