Diagnostic ability of barrett's index to detect dysthyroid optic neuropathy using multidetector computed tomography
OBJECTIVES: The objective of this study was to evaluate the ability of a muscular index (Barrett's Index), calculated with multidetector computed tomography, to detect dysthyroid optic neuropathy in patients with Graves' orbitopathy. METHODS: Thirty-six patients with Graves' orbitopat...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier España
2008-01-01
|
| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322008000300003 |
| _version_ | 1811318658418343936 |
|---|---|
| author | Mário L. R. Monteiro Allan C. P. Gonçalves Carla T. M. Silva Janete P. Moura Carolina S. Ribeiro Eloisa M.M.S. Gebrim |
| author_facet | Mário L. R. Monteiro Allan C. P. Gonçalves Carla T. M. Silva Janete P. Moura Carolina S. Ribeiro Eloisa M.M.S. Gebrim |
| author_sort | Mário L. R. Monteiro |
| collection | DOAJ |
| description | OBJECTIVES: The objective of this study was to evaluate the ability of a muscular index (Barrett's Index), calculated with multidetector computed tomography, to detect dysthyroid optic neuropathy in patients with Graves' orbitopathy. METHODS: Thirty-six patients with Graves' orbitopathy were prospectively studied and submitted to neuro-ophthalmic evaluation and multidetector computed tomography scans of the orbits. Orbits were divided into two groups: those with and without dysthyroid optic neuropathy. Barrett's index was calculated as the percentage of the orbit occupied by muscles. Sensitivity and specificity were determined for several index values. RESULTS: Sixty-four orbits (19 with and 45 without dysthyroid optic neuropathy) met the inclusion criteria for the study. The mean Barrett's index values (± SD) were 64.47% ± 6.06% and 49.44% ± 10.94%in the groups with and without dysthyroid optic neuropathy, respectively (p<0.001). Barrett's index sensitivity ranged from 32% to 100%, and Barrett's index specificity ranged from 24% to 100%. The best combination of sensitivity and specificity was 79%/72% for BI=60% (odds ratio: 9.2). CONCLUSIONS: Barrett's Index is a useful indicator of dysthyroid optic neuropathy and may contribute to early diagnosis and treatment. Patients with a Barrett's index >60% should be carefully examined and followed for the development of dysthyroid optic neuropathy. |
| first_indexed | 2024-04-13T12:29:31Z |
| format | Article |
| id | doaj.art-1c69f77b6cc64c7e9d50dd538c49e3bc |
| institution | Directory Open Access Journal |
| issn | 1807-5932 1980-5322 |
| language | English |
| last_indexed | 2024-04-13T12:29:31Z |
| publishDate | 2008-01-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-1c69f77b6cc64c7e9d50dd538c49e3bc2022-12-22T02:46:53ZengElsevier EspañaClinics1807-59321980-53222008-01-0163330130610.1590/S1807-59322008000300003Diagnostic ability of barrett's index to detect dysthyroid optic neuropathy using multidetector computed tomographyMário L. R. MonteiroAllan C. P. GonçalvesCarla T. M. SilvaJanete P. MouraCarolina S. RibeiroEloisa M.M.S. GebrimOBJECTIVES: The objective of this study was to evaluate the ability of a muscular index (Barrett's Index), calculated with multidetector computed tomography, to detect dysthyroid optic neuropathy in patients with Graves' orbitopathy. METHODS: Thirty-six patients with Graves' orbitopathy were prospectively studied and submitted to neuro-ophthalmic evaluation and multidetector computed tomography scans of the orbits. Orbits were divided into two groups: those with and without dysthyroid optic neuropathy. Barrett's index was calculated as the percentage of the orbit occupied by muscles. Sensitivity and specificity were determined for several index values. RESULTS: Sixty-four orbits (19 with and 45 without dysthyroid optic neuropathy) met the inclusion criteria for the study. The mean Barrett's index values (± SD) were 64.47% ± 6.06% and 49.44% ± 10.94%in the groups with and without dysthyroid optic neuropathy, respectively (p<0.001). Barrett's index sensitivity ranged from 32% to 100%, and Barrett's index specificity ranged from 24% to 100%. The best combination of sensitivity and specificity was 79%/72% for BI=60% (odds ratio: 9.2). CONCLUSIONS: Barrett's Index is a useful indicator of dysthyroid optic neuropathy and may contribute to early diagnosis and treatment. Patients with a Barrett's index >60% should be carefully examined and followed for the development of dysthyroid optic neuropathy.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322008000300003Dysthyroid Optic NeuropathyMultidetector computed tomographyGraves' OrbitopathyVisual lossThyroid eye disease |
| spellingShingle | Mário L. R. Monteiro Allan C. P. Gonçalves Carla T. M. Silva Janete P. Moura Carolina S. Ribeiro Eloisa M.M.S. Gebrim Diagnostic ability of barrett's index to detect dysthyroid optic neuropathy using multidetector computed tomography Clinics Dysthyroid Optic Neuropathy Multidetector computed tomography Graves' Orbitopathy Visual loss Thyroid eye disease |
| title | Diagnostic ability of barrett's index to detect dysthyroid optic neuropathy using multidetector computed tomography |
| title_full | Diagnostic ability of barrett's index to detect dysthyroid optic neuropathy using multidetector computed tomography |
| title_fullStr | Diagnostic ability of barrett's index to detect dysthyroid optic neuropathy using multidetector computed tomography |
| title_full_unstemmed | Diagnostic ability of barrett's index to detect dysthyroid optic neuropathy using multidetector computed tomography |
| title_short | Diagnostic ability of barrett's index to detect dysthyroid optic neuropathy using multidetector computed tomography |
| title_sort | diagnostic ability of barrett s index to detect dysthyroid optic neuropathy using multidetector computed tomography |
| topic | Dysthyroid Optic Neuropathy Multidetector computed tomography Graves' Orbitopathy Visual loss Thyroid eye disease |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322008000300003 |
| work_keys_str_mv | AT mariolrmonteiro diagnosticabilityofbarrettsindextodetectdysthyroidopticneuropathyusingmultidetectorcomputedtomography AT allancpgoncalves diagnosticabilityofbarrettsindextodetectdysthyroidopticneuropathyusingmultidetectorcomputedtomography AT carlatmsilva diagnosticabilityofbarrettsindextodetectdysthyroidopticneuropathyusingmultidetectorcomputedtomography AT janetepmoura diagnosticabilityofbarrettsindextodetectdysthyroidopticneuropathyusingmultidetectorcomputedtomography AT carolinasribeiro diagnosticabilityofbarrettsindextodetectdysthyroidopticneuropathyusingmultidetectorcomputedtomography AT eloisammsgebrim diagnosticabilityofbarrettsindextodetectdysthyroidopticneuropathyusingmultidetectorcomputedtomography |