Flow Process Development and Optimization of A Suzuki-Miyaura Cross Coupling Reaction using Response Surface Methodology
A custom-made tubular flow reactor was utilized to develop a mathematical model and optimize the Suzuki-Miyaura cross coupling reaction. In this study, the experimentation was designed and executed through the statistical design of experiments (DoE) approach via response surface methodology. The eff...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Masyarakat Katalis Indonesia - Indonesian Catalyst Society (MKICS)
2020-12-01
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| Series: | Bulletin of Chemical Reaction Engineering & Catalysis |
| Subjects: | |
| Online Access: | https://journal.bcrec.id/index.php/bcrec/article/view/8229 |
| _version_ | 1797677802424631296 |
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| author | Girish Basavaraju Ravishankar Rajanna |
| author_facet | Girish Basavaraju Ravishankar Rajanna |
| author_sort | Girish Basavaraju |
| collection | DOAJ |
| description | A custom-made tubular flow reactor was utilized to develop a mathematical model and optimize the Suzuki-Miyaura cross coupling reaction. In this study, the experimentation was designed and executed through the statistical design of experiments (DoE) approach via response surface methodology. The effect of molar ratios of phenylboronic acid (1) and 4-bromophenol (2), temperature, the catalyst tetrakis(triphenylphosphine)palladium, and equivalence of aqueous tripotassium phosphate was studied in detail. The flow reactor profile was in good agreement with batch conditions and significant improvements to the overall reaction time and selectivity towards desired [1-1-biphenyl]-4-ol (3) was achieved. The Suzuki coupling reaction in batch condition would take on an average of 4 to 6 hours to complete, which was effectively accomplished in 60 to 70 minutes in this tubular reactor setup and could be operated continuously. The reaction model is in good agreement with the reaction conditions. Copyright © 2021 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0). |
| first_indexed | 2024-03-11T22:50:25Z |
| format | Article |
| id | doaj.art-1c6bc4e3326e47c4b58d53b9e4eb1afc |
| institution | Directory Open Access Journal |
| issn | 1978-2993 |
| language | English |
| last_indexed | 2024-03-11T22:50:25Z |
| publishDate | 2020-12-01 |
| publisher | Masyarakat Katalis Indonesia - Indonesian Catalyst Society (MKICS) |
| record_format | Article |
| series | Bulletin of Chemical Reaction Engineering & Catalysis |
| spelling | doaj.art-1c6bc4e3326e47c4b58d53b9e4eb1afc2023-09-22T03:39:12ZengMasyarakat Katalis Indonesia - Indonesian Catalyst Society (MKICS)Bulletin of Chemical Reaction Engineering & Catalysis1978-29932020-12-0115360461610.9767/bcrec.15.3.8229.604-6163965Flow Process Development and Optimization of A Suzuki-Miyaura Cross Coupling Reaction using Response Surface MethodologyGirish Basavaraju0Ravishankar Rajanna1Department of Chemical Engineering, Dayananda Sagar College of Engineering, Bengaluru, IndiaDepartment of Chemical Engineering, Dayananda Sagar College of Engineering, Bengaluru, IndiaA custom-made tubular flow reactor was utilized to develop a mathematical model and optimize the Suzuki-Miyaura cross coupling reaction. In this study, the experimentation was designed and executed through the statistical design of experiments (DoE) approach via response surface methodology. The effect of molar ratios of phenylboronic acid (1) and 4-bromophenol (2), temperature, the catalyst tetrakis(triphenylphosphine)palladium, and equivalence of aqueous tripotassium phosphate was studied in detail. The flow reactor profile was in good agreement with batch conditions and significant improvements to the overall reaction time and selectivity towards desired [1-1-biphenyl]-4-ol (3) was achieved. The Suzuki coupling reaction in batch condition would take on an average of 4 to 6 hours to complete, which was effectively accomplished in 60 to 70 minutes in this tubular reactor setup and could be operated continuously. The reaction model is in good agreement with the reaction conditions. Copyright © 2021 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0).https://journal.bcrec.id/index.php/bcrec/article/view/8229continuous flow chemistrysuzuki coupling reactioncustomized flow reactortubular reactordesign of experiments (doe) |
| spellingShingle | Girish Basavaraju Ravishankar Rajanna Flow Process Development and Optimization of A Suzuki-Miyaura Cross Coupling Reaction using Response Surface Methodology Bulletin of Chemical Reaction Engineering & Catalysis continuous flow chemistry suzuki coupling reaction customized flow reactor tubular reactor design of experiments (doe) |
| title | Flow Process Development and Optimization of A Suzuki-Miyaura Cross Coupling Reaction using Response Surface Methodology |
| title_full | Flow Process Development and Optimization of A Suzuki-Miyaura Cross Coupling Reaction using Response Surface Methodology |
| title_fullStr | Flow Process Development and Optimization of A Suzuki-Miyaura Cross Coupling Reaction using Response Surface Methodology |
| title_full_unstemmed | Flow Process Development and Optimization of A Suzuki-Miyaura Cross Coupling Reaction using Response Surface Methodology |
| title_short | Flow Process Development and Optimization of A Suzuki-Miyaura Cross Coupling Reaction using Response Surface Methodology |
| title_sort | flow process development and optimization of a suzuki miyaura cross coupling reaction using response surface methodology |
| topic | continuous flow chemistry suzuki coupling reaction customized flow reactor tubular reactor design of experiments (doe) |
| url | https://journal.bcrec.id/index.php/bcrec/article/view/8229 |
| work_keys_str_mv | AT girishbasavaraju flowprocessdevelopmentandoptimizationofasuzukimiyauracrosscouplingreactionusingresponsesurfacemethodology AT ravishankarrajanna flowprocessdevelopmentandoptimizationofasuzukimiyauracrosscouplingreactionusingresponsesurfacemethodology |