Development and optimization of fast dissolving oro-dispersible films of granisetron HCl using Box–Behnken statistical design
The aim was to develop and optimize fast dissolving oro-dispersible films of granisetron hydrochloride (GH) by two-factor, three-level Box–Behnken design as the two independent variables such as X1 (polymer) and X2 (plasticizer) were selected on the basis of the preliminary studies carried out befor...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Faculty of Pharmacy, Cairo University
2013-12-01
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| Series: | Bulletin of Faculty of Pharmacy Cairo University |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110093113000264 |
| _version_ | 1797965600636534784 |
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| author | Hema Chaudhary Samita Gauri Permender Rathee Vikash Kumar |
| author_facet | Hema Chaudhary Samita Gauri Permender Rathee Vikash Kumar |
| author_sort | Hema Chaudhary |
| collection | DOAJ |
| description | The aim was to develop and optimize fast dissolving oro-dispersible films of granisetron hydrochloride (GH) by two-factor, three-level Box–Behnken design as the two independent variables such as X1 (polymer) and X2 (plasticizer) were selected on the basis of the preliminary studies carried out before the experimental design is being implemented. A second-order polynomial equation to construct contour plots for the prediction of responses of the dependent variables such as drug release (Y1), Disintegration time (Y2), and Y3 (Tensile strength) was studied. The Response surface plots were drawn, statistical validity of the polynomials was established to find the compositions of optimized formulation which was evaluated using the Franz-type diffusion cell. The designs establish the role of the derived polynomial equation and contour plots in predicting the values of dependent variables for the preparation and optimization. |
| first_indexed | 2024-04-11T02:02:36Z |
| format | Article |
| id | doaj.art-1c6c9fd14f18442591395d34005c60ac |
| institution | Directory Open Access Journal |
| issn | 1110-0931 |
| language | English |
| last_indexed | 2024-04-11T02:02:36Z |
| publishDate | 2013-12-01 |
| publisher | Faculty of Pharmacy, Cairo University |
| record_format | Article |
| series | Bulletin of Faculty of Pharmacy Cairo University |
| spelling | doaj.art-1c6c9fd14f18442591395d34005c60ac2023-01-03T03:47:53ZengFaculty of Pharmacy, Cairo UniversityBulletin of Faculty of Pharmacy Cairo University1110-09312013-12-0151219320110.1016/j.bfopcu.2013.05.002Development and optimization of fast dissolving oro-dispersible films of granisetron HCl using Box–Behnken statistical designHema ChaudharySamita GauriPermender RatheeVikash KumarThe aim was to develop and optimize fast dissolving oro-dispersible films of granisetron hydrochloride (GH) by two-factor, three-level Box–Behnken design as the two independent variables such as X1 (polymer) and X2 (plasticizer) were selected on the basis of the preliminary studies carried out before the experimental design is being implemented. A second-order polynomial equation to construct contour plots for the prediction of responses of the dependent variables such as drug release (Y1), Disintegration time (Y2), and Y3 (Tensile strength) was studied. The Response surface plots were drawn, statistical validity of the polynomials was established to find the compositions of optimized formulation which was evaluated using the Franz-type diffusion cell. The designs establish the role of the derived polynomial equation and contour plots in predicting the values of dependent variables for the preparation and optimization.http://www.sciencedirect.com/science/article/pii/S1110093113000264Fast oro-dispersible filmDrug designBox–Behnken designOptimization |
| spellingShingle | Hema Chaudhary Samita Gauri Permender Rathee Vikash Kumar Development and optimization of fast dissolving oro-dispersible films of granisetron HCl using Box–Behnken statistical design Bulletin of Faculty of Pharmacy Cairo University Fast oro-dispersible film Drug design Box–Behnken design Optimization |
| title | Development and optimization of fast dissolving oro-dispersible films of granisetron HCl using Box–Behnken statistical design |
| title_full | Development and optimization of fast dissolving oro-dispersible films of granisetron HCl using Box–Behnken statistical design |
| title_fullStr | Development and optimization of fast dissolving oro-dispersible films of granisetron HCl using Box–Behnken statistical design |
| title_full_unstemmed | Development and optimization of fast dissolving oro-dispersible films of granisetron HCl using Box–Behnken statistical design |
| title_short | Development and optimization of fast dissolving oro-dispersible films of granisetron HCl using Box–Behnken statistical design |
| title_sort | development and optimization of fast dissolving oro dispersible films of granisetron hcl using box behnken statistical design |
| topic | Fast oro-dispersible film Drug design Box–Behnken design Optimization |
| url | http://www.sciencedirect.com/science/article/pii/S1110093113000264 |
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