Knockdown of the TRPM4 channel alters cardiac electrophysiology and hemodynamics in a sex‐ and age‐dependent manner in mice

Knockdown of the TRPM4 channel alters cardiac electrophysiology and hemodynamics in a sex‐ and age‐dependent manner in mice

Abstract TRPM4 is a calcium‐activated, voltage‐modulated, nonselective ion channel widely expressed in various cells and tissues. TRPM4 regulates the influx of sodium ions, thus playing a role in regulating the membrane potential. In the heart, TRPM4 is expressed in both cardiomyocytes and cells of...

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Bibliographic Details
Main Authors: Prakash Arullampalam, Maria C. Essers, Mey Boukenna, Sabrina Guichard, Jean‐Sébastien Rougier, Hugues Abriel
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Physiological Reports
Subjects:
cardiac physiology
murine knockdown model
TRPM4 channels
Online Access:https://doi.org/10.14814/phy2.15783

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