High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation

High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation

Human-relevant tests to predict developmental toxicity are urgently needed. A currently intensively studied approach makes use of differentiating human stem cells to measure chemically-induced deviations of the normal developmental program, as in a recent study based on cardiac differentiation (UKK2...

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Bibliographic Details
Main Authors: Florian Seidel, Anna Cherianidou, Franziska Kappenberg, Miriam Marta, Nadine Dreser, Jonathan Blum, Tanja Waldmann, Nils Blüthgen, Johannes Meisig, Katrin Madjar, Margit Henry, Tamara Rotshteyn, Andreas Scholtz-Illigens, Rosemarie Marchan, Karolina Edlund, Marcel Leist, Jörg Rahnenführer, Agapios Sachinidis, Jan Georg Hengstler
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cells
Subjects:
alternative testing strategies
in vitro test
induced pluripotent stem cells
developmental and reproductive toxicity
drug screening
toxicogenomics
Online Access:https://www.mdpi.com/2073-4409/11/21/3404

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