CDC25C Protein Expression Correlates with Tumor Differentiation and Clinical Outcomes in Lung Adenocarcinoma
Given that, even after multimodal therapy, early-stage lung cancer (LC) often recurs, novel prognostic markers to help guide therapy are highly desired. The mRNA levels of cell division cycle 25C (CDC25C), a phosphatase that regulates G2/M cell cycle transition in malignant cells, correlate with poo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/2/362 |
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| author | Esther Stern Guy Pines Li Or Lazar Gilad W. Vainer Nitzan Beltran Omri Dodi Lika Gamaev Ofir Hikri Simon Michal Abraham Hanna Wald Amnon Peled Ori Wald |
| author_facet | Esther Stern Guy Pines Li Or Lazar Gilad W. Vainer Nitzan Beltran Omri Dodi Lika Gamaev Ofir Hikri Simon Michal Abraham Hanna Wald Amnon Peled Ori Wald |
| author_sort | Esther Stern |
| collection | DOAJ |
| description | Given that, even after multimodal therapy, early-stage lung cancer (LC) often recurs, novel prognostic markers to help guide therapy are highly desired. The mRNA levels of cell division cycle 25C (CDC25C), a phosphatase that regulates G2/M cell cycle transition in malignant cells, correlate with poor clinical outcomes in lung adenocarcinoma (LUAD). However, whether CDC25C protein detected by immunohistochemistry can serve as a prognostic marker in LUAD is yet unknown. We stained an LC tissue array and a cohort of 61 LUAD tissue sections for CDC25C and searched for correlations between CDC25C staining score and the pathological characteristics of the tumors and the patients’ clinical outcomes. Clinical data were retrieved from our prospectively maintained departmental database. We found that high expression of CDC25C was predominant among poorly differentiated LUAD (<i>p</i> < 0.001) and in LUAD > 1cm (<i>p</i> < 0.05). Further, high expression of CDC25C was associated with reduced disease-free survival (<i>p</i> = 0.03, median follow-up of 39 months) and with a trend for reduced overall survival (<i>p</i> = 0.08). Therefore, high expression of CDC25C protein in LUAD is associated with aggressive histological features and with poor outcomes. Larger studies are required to further validate CDC25C as a prognostic marker in LUAD. |
| first_indexed | 2024-03-11T09:06:40Z |
| format | Article |
| id | doaj.art-1c766516745448d38d85645aa3abed05 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T09:06:40Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj.art-1c766516745448d38d85645aa3abed052023-11-16T19:17:06ZengMDPI AGBiomedicines2227-90592023-01-0111236210.3390/biomedicines11020362CDC25C Protein Expression Correlates with Tumor Differentiation and Clinical Outcomes in Lung AdenocarcinomaEsther Stern0Guy Pines1Li Or Lazar2Gilad W. Vainer3Nitzan Beltran4Omri Dodi5Lika Gamaev6Ofir Hikri Simon7Michal Abraham8Hanna Wald9Amnon Peled10Ori Wald11Gene Therapy Institute, Hadassah Hebrew University Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, IsraelDepartment of General Surgery, Kaplan Hebrew University Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Rehovot 76100, IsraelDepartment of General Surgery, Kaplan Hebrew University Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Rehovot 76100, IsraelDepartment of Pathology, Hadassah Hebrew University Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, IsraelDepartment of Pathology, Kaplan Hebrew University Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Rehovot 76100, IsraelDepartment of Pathology, Kaplan Hebrew University Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Rehovot 76100, IsraelGene Therapy Institute, Hadassah Hebrew University Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, IsraelDepartment of General Thoracic Surgery, Kaplan Hebrew University Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Rehovot 76100, IsraelGene Therapy Institute, Hadassah Hebrew University Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, IsraelGene Therapy Institute, Hadassah Hebrew University Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, IsraelGene Therapy Institute, Hadassah Hebrew University Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, IsraelGene Therapy Institute, Hadassah Hebrew University Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, IsraelGiven that, even after multimodal therapy, early-stage lung cancer (LC) often recurs, novel prognostic markers to help guide therapy are highly desired. The mRNA levels of cell division cycle 25C (CDC25C), a phosphatase that regulates G2/M cell cycle transition in malignant cells, correlate with poor clinical outcomes in lung adenocarcinoma (LUAD). However, whether CDC25C protein detected by immunohistochemistry can serve as a prognostic marker in LUAD is yet unknown. We stained an LC tissue array and a cohort of 61 LUAD tissue sections for CDC25C and searched for correlations between CDC25C staining score and the pathological characteristics of the tumors and the patients’ clinical outcomes. Clinical data were retrieved from our prospectively maintained departmental database. We found that high expression of CDC25C was predominant among poorly differentiated LUAD (<i>p</i> < 0.001) and in LUAD > 1cm (<i>p</i> < 0.05). Further, high expression of CDC25C was associated with reduced disease-free survival (<i>p</i> = 0.03, median follow-up of 39 months) and with a trend for reduced overall survival (<i>p</i> = 0.08). Therefore, high expression of CDC25C protein in LUAD is associated with aggressive histological features and with poor outcomes. Larger studies are required to further validate CDC25C as a prognostic marker in LUAD.https://www.mdpi.com/2227-9059/11/2/362NSCLCCDC25Clung adenocarcinomalung cancer |
| spellingShingle | Esther Stern Guy Pines Li Or Lazar Gilad W. Vainer Nitzan Beltran Omri Dodi Lika Gamaev Ofir Hikri Simon Michal Abraham Hanna Wald Amnon Peled Ori Wald CDC25C Protein Expression Correlates with Tumor Differentiation and Clinical Outcomes in Lung Adenocarcinoma Biomedicines NSCLC CDC25C lung adenocarcinoma lung cancer |
| title | CDC25C Protein Expression Correlates with Tumor Differentiation and Clinical Outcomes in Lung Adenocarcinoma |
| title_full | CDC25C Protein Expression Correlates with Tumor Differentiation and Clinical Outcomes in Lung Adenocarcinoma |
| title_fullStr | CDC25C Protein Expression Correlates with Tumor Differentiation and Clinical Outcomes in Lung Adenocarcinoma |
| title_full_unstemmed | CDC25C Protein Expression Correlates with Tumor Differentiation and Clinical Outcomes in Lung Adenocarcinoma |
| title_short | CDC25C Protein Expression Correlates with Tumor Differentiation and Clinical Outcomes in Lung Adenocarcinoma |
| title_sort | cdc25c protein expression correlates with tumor differentiation and clinical outcomes in lung adenocarcinoma |
| topic | NSCLC CDC25C lung adenocarcinoma lung cancer |
| url | https://www.mdpi.com/2227-9059/11/2/362 |
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