Effective therapy of advanced breast cancer through synergistic anticancer by paclitaxel and P-glycoprotein inhibitor

Effective therapy of advanced breast cancer through synergistic anticancer by paclitaxel and P-glycoprotein inhibitor

Multi-drug resistance (MDR) in advanced breast cancer (ABC) is triggered by the high expression of P-glycoprotein (P-gp), which reduces intracellular concentration of anti-tumor drugs, in turn preventing oxidative stress damage to cytoplasmic and mitochondrial membranes. It is therefore of clinical...

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Bibliographic Details
Main Authors:	Sifeng Zhu, Chao Sun, Zimin Cai, Yunyan Li, Wendian Liu, Yun Luan, Cheng Wang
Format:	Article
Language:	English
Published:	Elsevier 2024-06-01
Series:	Materials Today Bio
Subjects:	Multi-drug resistance Mitochondria-targeting P-glycoprotein Advanced breast cancer Co-delivery Synergistic effect
Online Access:	http://www.sciencedirect.com/science/article/pii/S2590006424000887

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