Rhus coriaria extracts inhibit quorum sensing related virulence and biofilm production in drug-resistant Pseudomonas aeruginosa recovered from burn wounds
Objective(s): Numerous studies have confirmed sumac’s ability to inhibit pathogens and even eradicate chronic drug-resistant infections. Current research was conducted to demonstrate the action of various sumac extracts at sub-inhibitory concentrations in modulating pathogen-related characteristics...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2022-11-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | https://ijbms.mums.ac.ir/article_21091_52b1d953ca31ba49cc366c4a35db622b.pdf |
| _version_ | 1811192514829352960 |
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| author | Akhter Ahmed Fraidoon Salih Mohammad Yousef |
| author_facet | Akhter Ahmed Fraidoon Salih Mohammad Yousef |
| author_sort | Akhter Ahmed |
| collection | DOAJ |
| description | Objective(s): Numerous studies have confirmed sumac’s ability to inhibit pathogens and even eradicate chronic drug-resistant infections. Current research was conducted to demonstrate the action of various sumac extracts at sub-inhibitory concentrations in modulating pathogen-related characteristics instead of killing them.Materials and Methods: The influence of sumac extracts on the quorum sensing dependent virulence of multidrug-resistant isolates of Pseudomonas aeruginosa recovered from burn wounds was considered by detecting the effect on biofilm development, various virulence factors, and expression of bacterial exotoxin A and quorum sensing related genes. Results: Experiments to characterize and measure sumac extract’s impact on the P. aeruginosa growth, biofilm, exoproteases, pyocyanin, motility, and the quorum sensing networks revealed that all studied characteristics were reduced by concentrations below inhibition without affecting bacterial growth. Furthermore, the expression of exotoxin A, rhl, and las glucons was declined or even inhibited by lower levels of sumac fruit fractions. Conclusion: The findings revealed that sumac fights infections either by its inhibitory effect on the bacterial cells or by reducing bacterial signaling and virulence by disruption of the bacterial signal system. |
| first_indexed | 2024-04-11T23:54:53Z |
| format | Article |
| id | doaj.art-1c7ab4a8f68e401a875f0d52be4decc8 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-04-11T23:54:53Z |
| publishDate | 2022-11-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-1c7ab4a8f68e401a875f0d52be4decc82022-12-22T03:56:24ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742022-11-0125111349135610.22038/ijbms.2022.66085.1452721091Rhus coriaria extracts inhibit quorum sensing related virulence and biofilm production in drug-resistant Pseudomonas aeruginosa recovered from burn woundsAkhter Ahmed0Fraidoon Salih1Mohammad Yousef2Department of Biology, Salahaddin University- Erbil, Erbil, IraqDepartment of Biology, Salahaddin University- Erbil, Erbil, IraqMinistry of HealthObjective(s): Numerous studies have confirmed sumac’s ability to inhibit pathogens and even eradicate chronic drug-resistant infections. Current research was conducted to demonstrate the action of various sumac extracts at sub-inhibitory concentrations in modulating pathogen-related characteristics instead of killing them.Materials and Methods: The influence of sumac extracts on the quorum sensing dependent virulence of multidrug-resistant isolates of Pseudomonas aeruginosa recovered from burn wounds was considered by detecting the effect on biofilm development, various virulence factors, and expression of bacterial exotoxin A and quorum sensing related genes. Results: Experiments to characterize and measure sumac extract’s impact on the P. aeruginosa growth, biofilm, exoproteases, pyocyanin, motility, and the quorum sensing networks revealed that all studied characteristics were reduced by concentrations below inhibition without affecting bacterial growth. Furthermore, the expression of exotoxin A, rhl, and las glucons was declined or even inhibited by lower levels of sumac fruit fractions. Conclusion: The findings revealed that sumac fights infections either by its inhibitory effect on the bacterial cells or by reducing bacterial signaling and virulence by disruption of the bacterial signal system.https://ijbms.mums.ac.ir/article_21091_52b1d953ca31ba49cc366c4a35db622b.pdfbiofilmexotoxin apseudomonas aeruginosaquorum sensingsumac |
| spellingShingle | Akhter Ahmed Fraidoon Salih Mohammad Yousef Rhus coriaria extracts inhibit quorum sensing related virulence and biofilm production in drug-resistant Pseudomonas aeruginosa recovered from burn wounds Iranian Journal of Basic Medical Sciences biofilm exotoxin a pseudomonas aeruginosa quorum sensing sumac |
| title | Rhus coriaria extracts inhibit quorum sensing related virulence and biofilm production in drug-resistant Pseudomonas aeruginosa recovered from burn wounds |
| title_full | Rhus coriaria extracts inhibit quorum sensing related virulence and biofilm production in drug-resistant Pseudomonas aeruginosa recovered from burn wounds |
| title_fullStr | Rhus coriaria extracts inhibit quorum sensing related virulence and biofilm production in drug-resistant Pseudomonas aeruginosa recovered from burn wounds |
| title_full_unstemmed | Rhus coriaria extracts inhibit quorum sensing related virulence and biofilm production in drug-resistant Pseudomonas aeruginosa recovered from burn wounds |
| title_short | Rhus coriaria extracts inhibit quorum sensing related virulence and biofilm production in drug-resistant Pseudomonas aeruginosa recovered from burn wounds |
| title_sort | rhus coriaria extracts inhibit quorum sensing related virulence and biofilm production in drug resistant pseudomonas aeruginosa recovered from burn wounds |
| topic | biofilm exotoxin a pseudomonas aeruginosa quorum sensing sumac |
| url | https://ijbms.mums.ac.ir/article_21091_52b1d953ca31ba49cc366c4a35db622b.pdf |
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