Strategies for Solubility and Bioavailability Enhancement and Toxicity Reduction of Norcantharidin

Strategies for Solubility and Bioavailability Enhancement and Toxicity Reduction of Norcantharidin

Cantharidin (CTD) is the main active ingredient isolated from Mylabris, and norcantharidin (NCTD) is a demethylated derivative of CTD, which has similar antitumor activity to CTD and lower toxicity than CTD. However, the clinical use of NCTD is limited due to its poor solubility, low bioavailability...

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Bibliographic Details
Main Authors: Qian Liu, Henglai Sun, Xinyu Li, Huagang Sheng, Liqiao Zhu
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
norcantharidin
solubility
bioavailability
antitumor
structural modification
nanopreparation
Online Access:https://www.mdpi.com/1420-3049/27/22/7740

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