Non-Steroidal Anti-inflammatories: Does carprofen or meloxicam have fewer gastrointestinal side effects?
PICO question In canines, does the oral administration of carprofen, when compared to meloxicam, result in fewer gastrointestinal side effects? Clinical bottom line Category of research question Treatment The number and type of study designs reviewed Three prospective randomis...
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| Format: | Article |
| Language: | English |
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RCVS Knowledge
2020-09-01
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| Series: | Veterinary Evidence |
| Subjects: | |
| Online Access: | https://veterinaryevidence.org/index.php/ve/article/view/301 |
| _version_ | 1819173140124663808 |
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| author | Aaron Harold Andrew Fletcher |
| author_facet | Aaron Harold Andrew Fletcher |
| author_sort | Aaron Harold Andrew Fletcher |
| collection | DOAJ |
| description | PICO question
In canines, does the oral administration of carprofen, when compared to meloxicam, result in fewer gastrointestinal side effects?
Clinical bottom line
Category of research question
Treatment
The number and type of study designs reviewed
Three prospective randomised controlled trials were critically reviewed
Strength of evidence
Weak
Outcomes reported
Treatment with carprofen or meloxicam results in no significant difference in gastric lesion scoring, increased intestinal mucosal permeability or diminished small bowel absorptive capacity
Conclusion
There is insufficient evidence supporting preferential administration of carprofen or meloxicam to reduce gastrointestinal side effects
How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision-making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care |
| first_indexed | 2024-12-22T20:18:20Z |
| format | Article |
| id | doaj.art-1c7c373450b146f1a3c211188617c808 |
| institution | Directory Open Access Journal |
| issn | 2396-9776 |
| language | English |
| last_indexed | 2024-12-22T20:18:20Z |
| publishDate | 2020-09-01 |
| publisher | RCVS Knowledge |
| record_format | Article |
| series | Veterinary Evidence |
| spelling | doaj.art-1c7c373450b146f1a3c211188617c8082022-12-21T18:13:55ZengRCVS KnowledgeVeterinary Evidence2396-97762020-09-015310.18849/ve.v5i3.301301Non-Steroidal Anti-inflammatories: Does carprofen or meloxicam have fewer gastrointestinal side effects?Aaron Harold Andrew Fletcher0Heath Lodge Vets St Albans Herts AL10 8TXPICO question In canines, does the oral administration of carprofen, when compared to meloxicam, result in fewer gastrointestinal side effects? Clinical bottom line Category of research question Treatment The number and type of study designs reviewed Three prospective randomised controlled trials were critically reviewed Strength of evidence Weak Outcomes reported Treatment with carprofen or meloxicam results in no significant difference in gastric lesion scoring, increased intestinal mucosal permeability or diminished small bowel absorptive capacity Conclusion There is insufficient evidence supporting preferential administration of carprofen or meloxicam to reduce gastrointestinal side effects How to apply this evidence in practice The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources. Knowledge Summaries are a resource to help reinforce or inform decision-making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their carehttps://veterinaryevidence.org/index.php/ve/article/view/301non-steroidal anti-inflammatoriesmeloxicamcarprofengastrointestinaladverse drug reactionside effects |
| spellingShingle | Aaron Harold Andrew Fletcher Non-Steroidal Anti-inflammatories: Does carprofen or meloxicam have fewer gastrointestinal side effects? Veterinary Evidence non-steroidal anti-inflammatories meloxicam carprofen gastrointestinal adverse drug reaction side effects |
| title | Non-Steroidal Anti-inflammatories: Does carprofen or meloxicam have fewer gastrointestinal side effects? |
| title_full | Non-Steroidal Anti-inflammatories: Does carprofen or meloxicam have fewer gastrointestinal side effects? |
| title_fullStr | Non-Steroidal Anti-inflammatories: Does carprofen or meloxicam have fewer gastrointestinal side effects? |
| title_full_unstemmed | Non-Steroidal Anti-inflammatories: Does carprofen or meloxicam have fewer gastrointestinal side effects? |
| title_short | Non-Steroidal Anti-inflammatories: Does carprofen or meloxicam have fewer gastrointestinal side effects? |
| title_sort | non steroidal anti inflammatories does carprofen or meloxicam have fewer gastrointestinal side effects |
| topic | non-steroidal anti-inflammatories meloxicam carprofen gastrointestinal adverse drug reaction side effects |
| url | https://veterinaryevidence.org/index.php/ve/article/view/301 |
| work_keys_str_mv | AT aaronharoldandrewfletcher nonsteroidalantiinflammatoriesdoescarprofenormeloxicamhavefewergastrointestinalsideeffects |