Biologically Targeted Photo‐Crosslinkable Nanopatch to Prevent Postsurgical Peritoneal Adhesion
Abstract Peritoneal adhesion occurs in a majority of patients following abdominal surgery and can result in significant side effects and complications. Current strategies to minimize adhesions involve the use of nontargeted anatomical barriers that are either inefficient in protecting injured areas...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-10-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.201900809 |
| _version_ | 1811241502504910848 |
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| author | Yu Mi Feifei Yang Cameron Bloomquist Youli Xia Bo Sun Yanfei Qi Kyle Wagner Stephanie A. Montgomery Tian Zhang Andrew Z. Wang |
| author_facet | Yu Mi Feifei Yang Cameron Bloomquist Youli Xia Bo Sun Yanfei Qi Kyle Wagner Stephanie A. Montgomery Tian Zhang Andrew Z. Wang |
| author_sort | Yu Mi |
| collection | DOAJ |
| description | Abstract Peritoneal adhesion occurs in a majority of patients following abdominal surgery and can result in significant side effects and complications. Current strategies to minimize adhesions involve the use of nontargeted anatomical barriers that are either inefficient in protecting injured areas or lacking the adequate residence time to prevent adhesions. Herein, the development of a biologically targeted photo‐crosslinkable nanopatch (pCNP) is reported that can prevent postsurgical adhesion. It is demonstrated that pCNP can form a compact protective barrier over surfaces with exposed collagen IV. Using a rat parietal peritoneal excision adhesion model, it is showed that pCNP is highly effective and safe in preventing postsurgical adhesions. This work presents a novel approach to preventing peritoneal adhesion with nanomaterials. |
| first_indexed | 2024-04-12T13:37:08Z |
| format | Article |
| id | doaj.art-1c7de54e1ee544a7a02c93804448576d |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-12T13:37:08Z |
| publishDate | 2019-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-1c7de54e1ee544a7a02c93804448576d2022-12-22T03:30:57ZengWileyAdvanced Science2198-38442019-10-01619n/an/a10.1002/advs.201900809Biologically Targeted Photo‐Crosslinkable Nanopatch to Prevent Postsurgical Peritoneal AdhesionYu Mi0Feifei Yang1Cameron Bloomquist2Youli Xia3Bo Sun4Yanfei Qi5Kyle Wagner6Stephanie A. Montgomery7Tian Zhang8Andrew Z. Wang9Laboratory of Nano‐ and Translational Medicine Carolina Center for Cancer Nanotechnology Excellence Carolina Institute of Nanomedicine Lineberger Comprehensive Cancer Center Department of Radiation Oncology University of North Carolina at Chapel Hill Chapel Hill NC 27599 USALaboratory of Nano‐ and Translational Medicine Carolina Center for Cancer Nanotechnology Excellence Carolina Institute of Nanomedicine Lineberger Comprehensive Cancer Center Department of Radiation Oncology University of North Carolina at Chapel Hill Chapel Hill NC 27599 USALaboratory of Nano‐ and Translational Medicine Carolina Center for Cancer Nanotechnology Excellence Carolina Institute of Nanomedicine Lineberger Comprehensive Cancer Center Department of Radiation Oncology University of North Carolina at Chapel Hill Chapel Hill NC 27599 USADepartment of Genetics University of North Carolina at Chapel Hill Chapel Hill NC 27599 USALaboratory of Nano‐ and Translational Medicine Carolina Center for Cancer Nanotechnology Excellence Carolina Institute of Nanomedicine Lineberger Comprehensive Cancer Center Department of Radiation Oncology University of North Carolina at Chapel Hill Chapel Hill NC 27599 USALaboratory of Nano‐ and Translational Medicine Carolina Center for Cancer Nanotechnology Excellence Carolina Institute of Nanomedicine Lineberger Comprehensive Cancer Center Department of Radiation Oncology University of North Carolina at Chapel Hill Chapel Hill NC 27599 USALaboratory of Nano‐ and Translational Medicine Carolina Center for Cancer Nanotechnology Excellence Carolina Institute of Nanomedicine Lineberger Comprehensive Cancer Center Department of Radiation Oncology University of North Carolina at Chapel Hill Chapel Hill NC 27599 USADepartment of Pathology and Laboratory Medicine University of North Carolina at Chapel Hill Chapel Hill NC 27599 USADepartment of Medical Oncology Department of Medicine Duke University Medical Center Durham NC 27710 USALaboratory of Nano‐ and Translational Medicine Carolina Center for Cancer Nanotechnology Excellence Carolina Institute of Nanomedicine Lineberger Comprehensive Cancer Center Department of Radiation Oncology University of North Carolina at Chapel Hill Chapel Hill NC 27599 USAAbstract Peritoneal adhesion occurs in a majority of patients following abdominal surgery and can result in significant side effects and complications. Current strategies to minimize adhesions involve the use of nontargeted anatomical barriers that are either inefficient in protecting injured areas or lacking the adequate residence time to prevent adhesions. Herein, the development of a biologically targeted photo‐crosslinkable nanopatch (pCNP) is reported that can prevent postsurgical adhesion. It is demonstrated that pCNP can form a compact protective barrier over surfaces with exposed collagen IV. Using a rat parietal peritoneal excision adhesion model, it is showed that pCNP is highly effective and safe in preventing postsurgical adhesions. This work presents a novel approach to preventing peritoneal adhesion with nanomaterials.https://doi.org/10.1002/advs.201900809abdominal surgerybiological targetingnanomaterialsperitoneal adhesionphoto‐crosslinking |
| spellingShingle | Yu Mi Feifei Yang Cameron Bloomquist Youli Xia Bo Sun Yanfei Qi Kyle Wagner Stephanie A. Montgomery Tian Zhang Andrew Z. Wang Biologically Targeted Photo‐Crosslinkable Nanopatch to Prevent Postsurgical Peritoneal Adhesion Advanced Science abdominal surgery biological targeting nanomaterials peritoneal adhesion photo‐crosslinking |
| title | Biologically Targeted Photo‐Crosslinkable Nanopatch to Prevent Postsurgical Peritoneal Adhesion |
| title_full | Biologically Targeted Photo‐Crosslinkable Nanopatch to Prevent Postsurgical Peritoneal Adhesion |
| title_fullStr | Biologically Targeted Photo‐Crosslinkable Nanopatch to Prevent Postsurgical Peritoneal Adhesion |
| title_full_unstemmed | Biologically Targeted Photo‐Crosslinkable Nanopatch to Prevent Postsurgical Peritoneal Adhesion |
| title_short | Biologically Targeted Photo‐Crosslinkable Nanopatch to Prevent Postsurgical Peritoneal Adhesion |
| title_sort | biologically targeted photo crosslinkable nanopatch to prevent postsurgical peritoneal adhesion |
| topic | abdominal surgery biological targeting nanomaterials peritoneal adhesion photo‐crosslinking |
| url | https://doi.org/10.1002/advs.201900809 |
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