Celiac disease T-cell epitopes from gamma-gliadins: immunoreactivity depends on the genome of origin, transcript frequency, and flanking protein variation

Celiac disease T-cell epitopes from gamma-gliadins: immunoreactivity depends on the genome of origin, transcript frequency, and flanking protein variation

<p>Abstract</p> <p>Background</p> <p>Celiac disease (CD) is caused by an uncontrolled immune response to gluten, a heterogeneous mixture of wheat storage proteins. The CD-toxicity of these proteins and their derived peptides is depending on the presence of specific T-ce...

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Bibliographic Details
Main Authors: Salentijn Elma MJ, Mitea D, Goryunova Svetlana V, van der Meer Ingrid M, Padioleau Ismael, Gilissen Luud JWJ, Koning Frits, Smulders Marinus JM
Format: Article
Language:English
Published: BMC 2012-06-01
Series:BMC Genomics
Subjects:
Wheat
Gluten
γ-gliadins
Celiac disease
T-cell epitopes
Online Access:http://www.biomedcentral.com/1471-2164/13/277

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