Delta radiomic patterns on serial bi-parametric MRI are associated with pathologic upgrading in prostate cancer patients on active surveillance: preliminary findings
ObjectiveThe aim of this study was to quantify radiomic changes in prostate cancer (PCa) progression on serial MRI among patients on active surveillance (AS) and evaluate their association with pathologic progression on biopsy.MethodsThis retrospective study comprised N = 121 biopsy-proven PCa patie...
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| Format: | Article |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1166047/full |
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| author | Abhishek Midya Amogh Hiremath Jacob Huber Vidya Sankar Viswanathan Danly Omil-Lima Amr Mahran Leonardo K. Bittencourt Sree Harsha Tirumani Lee Ponsky Rakesh Shiradkar Anant Madabhushi Anant Madabhushi |
| author_facet | Abhishek Midya Amogh Hiremath Jacob Huber Vidya Sankar Viswanathan Danly Omil-Lima Amr Mahran Leonardo K. Bittencourt Sree Harsha Tirumani Lee Ponsky Rakesh Shiradkar Anant Madabhushi Anant Madabhushi |
| author_sort | Abhishek Midya |
| collection | DOAJ |
| description | ObjectiveThe aim of this study was to quantify radiomic changes in prostate cancer (PCa) progression on serial MRI among patients on active surveillance (AS) and evaluate their association with pathologic progression on biopsy.MethodsThis retrospective study comprised N = 121 biopsy-proven PCa patients on AS at a single institution, of whom N = 50 at baseline conformed to the inclusion criteria. ISUP Gleason Grade Groups (GGG) were obtained from 12-core TRUS-guided systematic biopsies at baseline and follow-up. A biopsy upgrade (AS+) was defined as an increase in GGG (or in number of positive cores) and no upgrade (AS−) was defined when GGG remained the same during a median period of 18 months. Of N = 50 patients at baseline, N = 30 had MRI scans available at follow-up (median interval = 18 months) and were included for delta radiomic analysis. A total of 252 radiomic features were extracted from the PCa region of interest identified by board-certified radiologists on 3T bi-parametric MRI [T2-weighted (T2W) and apparent diffusion coefficient (ADC)]. Delta radiomic features were computed as the difference of radiomic feature between baseline and follow-up scans. The association of AS+ with age, prostate-specific antigen (PSA), Prostate Imaging Reporting and Data System (PIRADS v2.1) score, and tumor size was evaluated at baseline and follow-up. Various prediction models were built using random forest (RF) classifier within a threefold cross-validation framework leveraging baseline radiomics (Cbr), baseline radiomics + baseline clinical (Cbrbcl), delta radiomics (CΔr), delta radiomics + baseline clinical (CΔrbcl), and delta radiomics + delta clinical (CΔrΔcl).ResultsAn AUC of 0.64 ± 0.09 was obtained for Cbr, which increased to 0.70 ± 0.18 with the integration of clinical variables (Cbrbcl). CΔr yielded an AUC of 0.74 ± 0.15. Integrating delta radiomics with baseline clinical variables yielded an AUC of 0.77 ± 0.23. CΔrΔclresulted in the best AUC of 0.84 ± 0.20 (p < 0.05) among all combinations.ConclusionOur preliminary findings suggest that delta radiomics were more strongly associated with upgrade events compared to PIRADS and other clinical variables. Delta radiomics on serial MRI in combination with changes in clinical variables (PSA and tumor volume) between baseline and follow-up showed the strongest association with biopsy upgrade in PCa patients on AS. Further independent multi-site validation of these preliminary findings is warranted. |
| first_indexed | 2024-03-12T02:27:41Z |
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| language | English |
| last_indexed | 2024-03-12T02:27:41Z |
| publishDate | 2023-09-01 |
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| series | Frontiers in Oncology |
| spelling | doaj.art-1c7f6b0f949b456199b99a03e6a5e21c2023-09-05T11:00:07ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-09-011310.3389/fonc.2023.11660471166047Delta radiomic patterns on serial bi-parametric MRI are associated with pathologic upgrading in prostate cancer patients on active surveillance: preliminary findingsAbhishek Midya0Amogh Hiremath1Jacob Huber2Vidya Sankar Viswanathan3Danly Omil-Lima4Amr Mahran5Leonardo K. Bittencourt6Sree Harsha Tirumani7Lee Ponsky8Rakesh Shiradkar9Anant Madabhushi10Anant Madabhushi11Department of Biomedical Engineering, Emory University, Atlanta, GA, United StatesPicture Health, Cleveland, OH, United StatesDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United StatesDepartment of Biomedical Engineering, Emory University, Atlanta, GA, United StatesFox Chase Cancer Center, Philadelphia, PA, United StatesDepartment of Urology, Assiut University, Asyut, EgyptDepartment of Radiology, University Hospitals, Cleveland Medical Center, Cleveland, OH, United StatesDepartment of Radiology, University Hospitals, Cleveland Medical Center, Cleveland, OH, United StatesDepartment of Urology, University Hospitals, Cleveland Medical Center, Cleveland, OH, United StatesDepartment of Biomedical Engineering, Emory University, Atlanta, GA, United StatesDepartment of Biomedical Engineering, Emory University, Atlanta, GA, United StatesAtlanta Veterans Administration Medical Center, Atlanta, GA, United StatesObjectiveThe aim of this study was to quantify radiomic changes in prostate cancer (PCa) progression on serial MRI among patients on active surveillance (AS) and evaluate their association with pathologic progression on biopsy.MethodsThis retrospective study comprised N = 121 biopsy-proven PCa patients on AS at a single institution, of whom N = 50 at baseline conformed to the inclusion criteria. ISUP Gleason Grade Groups (GGG) were obtained from 12-core TRUS-guided systematic biopsies at baseline and follow-up. A biopsy upgrade (AS+) was defined as an increase in GGG (or in number of positive cores) and no upgrade (AS−) was defined when GGG remained the same during a median period of 18 months. Of N = 50 patients at baseline, N = 30 had MRI scans available at follow-up (median interval = 18 months) and were included for delta radiomic analysis. A total of 252 radiomic features were extracted from the PCa region of interest identified by board-certified radiologists on 3T bi-parametric MRI [T2-weighted (T2W) and apparent diffusion coefficient (ADC)]. Delta radiomic features were computed as the difference of radiomic feature between baseline and follow-up scans. The association of AS+ with age, prostate-specific antigen (PSA), Prostate Imaging Reporting and Data System (PIRADS v2.1) score, and tumor size was evaluated at baseline and follow-up. Various prediction models were built using random forest (RF) classifier within a threefold cross-validation framework leveraging baseline radiomics (Cbr), baseline radiomics + baseline clinical (Cbrbcl), delta radiomics (CΔr), delta radiomics + baseline clinical (CΔrbcl), and delta radiomics + delta clinical (CΔrΔcl).ResultsAn AUC of 0.64 ± 0.09 was obtained for Cbr, which increased to 0.70 ± 0.18 with the integration of clinical variables (Cbrbcl). CΔr yielded an AUC of 0.74 ± 0.15. Integrating delta radiomics with baseline clinical variables yielded an AUC of 0.77 ± 0.23. CΔrΔclresulted in the best AUC of 0.84 ± 0.20 (p < 0.05) among all combinations.ConclusionOur preliminary findings suggest that delta radiomics were more strongly associated with upgrade events compared to PIRADS and other clinical variables. Delta radiomics on serial MRI in combination with changes in clinical variables (PSA and tumor volume) between baseline and follow-up showed the strongest association with biopsy upgrade in PCa patients on AS. Further independent multi-site validation of these preliminary findings is warranted.https://www.frontiersin.org/articles/10.3389/fonc.2023.1166047/fullactive surveillanceprostate cancerradiomicsmagnetic resonance imaginingpathologic upgrade |
| spellingShingle | Abhishek Midya Amogh Hiremath Jacob Huber Vidya Sankar Viswanathan Danly Omil-Lima Amr Mahran Leonardo K. Bittencourt Sree Harsha Tirumani Lee Ponsky Rakesh Shiradkar Anant Madabhushi Anant Madabhushi Delta radiomic patterns on serial bi-parametric MRI are associated with pathologic upgrading in prostate cancer patients on active surveillance: preliminary findings Frontiers in Oncology active surveillance prostate cancer radiomics magnetic resonance imagining pathologic upgrade |
| title | Delta radiomic patterns on serial bi-parametric MRI are associated with pathologic upgrading in prostate cancer patients on active surveillance: preliminary findings |
| title_full | Delta radiomic patterns on serial bi-parametric MRI are associated with pathologic upgrading in prostate cancer patients on active surveillance: preliminary findings |
| title_fullStr | Delta radiomic patterns on serial bi-parametric MRI are associated with pathologic upgrading in prostate cancer patients on active surveillance: preliminary findings |
| title_full_unstemmed | Delta radiomic patterns on serial bi-parametric MRI are associated with pathologic upgrading in prostate cancer patients on active surveillance: preliminary findings |
| title_short | Delta radiomic patterns on serial bi-parametric MRI are associated with pathologic upgrading in prostate cancer patients on active surveillance: preliminary findings |
| title_sort | delta radiomic patterns on serial bi parametric mri are associated with pathologic upgrading in prostate cancer patients on active surveillance preliminary findings |
| topic | active surveillance prostate cancer radiomics magnetic resonance imagining pathologic upgrade |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1166047/full |
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