Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress

Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress

BackgroundThe amino acid response (AAR) is an evolutionarily conserved protective mechanism activated by amino acid deficiency through a key kinase, general control nonderepressible 2. In addition to mobilizing amino acids, the AAR broadly affects gene and protein expression in a variety of pathways...

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Main Authors: Pu Qin, Pelin Arabacilar, Roberta E. Bernard, Weike Bao, Alan R. Olzinski, Yuanjun Guo, Hind Lal, Stephen H. Eisennagel, Michael C. Platchek, Wensheng Xie, Julius del Rosario, Mohamad Nayal, Quinn Lu, Theresa Roethke, Christine G. Schnackenberg, Fe Wright, Michael P. Quaile, Wendy S. Halsey, Ashley M. Hughes, Ganesh M. Sathe, George P. Livi, Robert B. Kirkpatrick, Xiaoyan A. Qu, Deepak K. Rajpal, Maria Faelth Savitski, Marcus Bantscheff, Gerard Joberty, Giovanna Bergamini, Thomas L. Force, Gregory J. Gatto, Erding Hu, Robert N. Willette
Format: Article
Language:English
Published: Wiley 2017-05-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
amino acid response
fibrosis
halofuginone
heart failure
hypertrophy
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.116.004453

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