Targeted next-generation sequencing of 21 candidate genes in hereditary ovarian cancer patients from the Republic of Bashkortostan

Targeted next-generation sequencing of 21 candidate genes in hereditary ovarian cancer patients from the Republic of Bashkortostan

Abstract About 5–10% of all ovarian cancer cases show familial clustering, and some 15–25% of familial ovarian cancer cases are mediated by high-penetrance mutations in the BRCA1 and BRCA2 genes. Only few other genes have been identified for familial ovarian cancer. We conducted targeted next-genera...

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Bibliographic Details
Main Authors: D. S. Prokofyeva, E. T. Mingazheva, Ya. V. Valova, D. D. Sakaeva, R. R. Faishanova, A. Kh. Nurgalieva, R. R. Valiev, N. Bogdanova, T. Dörk, E. K. Khusnutdinova
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Journal of Ovarian Research
Subjects:
Hereditary ovarian cancer
Target sequencing
Germline mutations
Pathogenic variants
Likely pathogenic variants
Online Access:https://doi.org/10.1186/s13048-023-01119-z

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