Tenofovir as Rescue Therapy Following Clinical Failure to Lamivudine in Severe Acute Hepatitis B
Acute hepatitis B (AHB) is a self-limiting condition in more than 95% of cases. Treatment is however recommended in patients with severe AHB (<1% of cases), aiming to prevent liver failure and death. Various nucleos(t)ide analogues (NA) have been found to be effective in severe AHB, although NA-r...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2013-06-01
|
| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/473 |
| _version_ | 1826909090802040832 |
|---|---|
| author | Jurgen Gerada Elaine Borg Denise Formosa Rosalie Magro James Pocock |
| author_facet | Jurgen Gerada Elaine Borg Denise Formosa Rosalie Magro James Pocock |
| author_sort | Jurgen Gerada |
| collection | DOAJ |
| description | Acute hepatitis B (AHB) is a self-limiting condition in more than 95% of cases. Treatment is however recommended in patients with severe AHB (<1% of cases), aiming to prevent liver failure and death. Various nucleos(t)ide analogues (NA) have been found to be effective in severe AHB, although NA-resistant strains causing AHB have been also recently reported. The use of tenofovir in this setting has only been reported once with a favorable outcome. We hereby report a 47-year-old treatment-naïve male, who developed severe AHB and was treated with lamivudine (LMV). Initial rapid biochemical response was followed by biochemical breakthrough after 9 days, suggesting LMV resistance. Rescue therapy with ‘add-on’ tenofovir brought about a sustained improvement in biochemical, serological and virological markers until HBsAg was lost after 4 months. Thus, this is the second case reporting the successful use of tenofovir in severe AHB. |
| first_indexed | 2024-12-22T06:42:20Z |
| format | Article |
| id | doaj.art-1c80c3807166427a9a3b693d9f3122a4 |
| institution | Directory Open Access Journal |
| issn | 2035-3006 |
| language | English |
| last_indexed | 2025-02-17T09:34:49Z |
| publishDate | 2013-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj.art-1c80c3807166427a9a3b693d9f3122a42025-01-02T09:44:27ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062013-06-0151e2013035e201303510.4084/mjhid.2013.035365Tenofovir as Rescue Therapy Following Clinical Failure to Lamivudine in Severe Acute Hepatitis BJurgen Gerada0Elaine Borg1Denise Formosa2Rosalie Magro3James Pocock4Mater Dei HospitalMater Dei HospitalMater Dei HospitalMater Dei HospitalMater Dei HospitalAcute hepatitis B (AHB) is a self-limiting condition in more than 95% of cases. Treatment is however recommended in patients with severe AHB (<1% of cases), aiming to prevent liver failure and death. Various nucleos(t)ide analogues (NA) have been found to be effective in severe AHB, although NA-resistant strains causing AHB have been also recently reported. The use of tenofovir in this setting has only been reported once with a favorable outcome. We hereby report a 47-year-old treatment-naïve male, who developed severe AHB and was treated with lamivudine (LMV). Initial rapid biochemical response was followed by biochemical breakthrough after 9 days, suggesting LMV resistance. Rescue therapy with ‘add-on’ tenofovir brought about a sustained improvement in biochemical, serological and virological markers until HBsAg was lost after 4 months. Thus, this is the second case reporting the successful use of tenofovir in severe AHB.http://www.mjhid.org/index.php/mjhid/article/view/473hepatitis Blamivudineliver failureresistancetenofovir |
| spellingShingle | Jurgen Gerada Elaine Borg Denise Formosa Rosalie Magro James Pocock Tenofovir as Rescue Therapy Following Clinical Failure to Lamivudine in Severe Acute Hepatitis B Mediterranean Journal of Hematology and Infectious Diseases hepatitis B lamivudine liver failure resistance tenofovir |
| title | Tenofovir as Rescue Therapy Following Clinical Failure to Lamivudine in Severe Acute Hepatitis B |
| title_full | Tenofovir as Rescue Therapy Following Clinical Failure to Lamivudine in Severe Acute Hepatitis B |
| title_fullStr | Tenofovir as Rescue Therapy Following Clinical Failure to Lamivudine in Severe Acute Hepatitis B |
| title_full_unstemmed | Tenofovir as Rescue Therapy Following Clinical Failure to Lamivudine in Severe Acute Hepatitis B |
| title_short | Tenofovir as Rescue Therapy Following Clinical Failure to Lamivudine in Severe Acute Hepatitis B |
| title_sort | tenofovir as rescue therapy following clinical failure to lamivudine in severe acute hepatitis b |
| topic | hepatitis B lamivudine liver failure resistance tenofovir |
| url | http://www.mjhid.org/index.php/mjhid/article/view/473 |
| work_keys_str_mv | AT jurgengerada tenofovirasrescuetherapyfollowingclinicalfailuretolamivudineinsevereacutehepatitisb AT elaineborg tenofovirasrescuetherapyfollowingclinicalfailuretolamivudineinsevereacutehepatitisb AT deniseformosa tenofovirasrescuetherapyfollowingclinicalfailuretolamivudineinsevereacutehepatitisb AT rosaliemagro tenofovirasrescuetherapyfollowingclinicalfailuretolamivudineinsevereacutehepatitisb AT jamespocock tenofovirasrescuetherapyfollowingclinicalfailuretolamivudineinsevereacutehepatitisb |