Acanthosis nigricans – a common significant disorder usually unassociated with malignancy
Acanthosis nigricans (AN) can be a highly significant cutaneous findingand is usually unrelated to cancer. It is most often evident as velvetythickening of axillae, posterior neck fold, flexor skin surfaces andumbilicus. It is common in obesity, which is seen increasing in childrenand adolescents, a...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2011-03-01
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| Series: | Przegląd Dermatologiczny |
| Subjects: | |
| Online Access: | http://www.termedia.pl/Prace-Specjalne-Acanthosis-nigricans-a-common-significant-disorder-usually-unassociated-with-malignancy,56,16300,1,0.html |
| _version_ | 1819076533512306688 |
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| author | Edmund J. Janniger Robert A. Schwartz |
| author_facet | Edmund J. Janniger Robert A. Schwartz |
| author_sort | Edmund J. Janniger |
| collection | DOAJ |
| description | Acanthosis nigricans (AN) can be a highly significant cutaneous findingand is usually unrelated to cancer. It is most often evident as velvetythickening of axillae, posterior neck fold, flexor skin surfaces andumbilicus. It is common in obesity, which is seen increasing in childrenand adolescents, and can serve as a cutaneous marker of insulin resistance.It is most often associated with hyperinsulinemia, which mayresult from insulin receptor gene defects causing insulin resistance, andless frequently due to mutations in fibroblast growth factor receptors.In this work non malignancy-associated AN types will be emphasized,particularly the association of AN with insulin-resistance, itself a potentialthreat to life. |
| first_indexed | 2024-12-21T18:42:49Z |
| format | Article |
| id | doaj.art-1c8195c1fbd24fbb98742179130d842a |
| institution | Directory Open Access Journal |
| issn | 0033-2526 |
| language | English |
| last_indexed | 2024-12-21T18:42:49Z |
| publishDate | 2011-03-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Przegląd Dermatologiczny |
| spelling | doaj.art-1c8195c1fbd24fbb98742179130d842a2022-12-21T18:53:58ZengTermedia Publishing HousePrzegląd Dermatologiczny0033-25262011-03-0198116Acanthosis nigricans – a common significant disorder usually unassociated with malignancyEdmund J. JannigerRobert A. SchwartzAcanthosis nigricans (AN) can be a highly significant cutaneous findingand is usually unrelated to cancer. It is most often evident as velvetythickening of axillae, posterior neck fold, flexor skin surfaces andumbilicus. It is common in obesity, which is seen increasing in childrenand adolescents, and can serve as a cutaneous marker of insulin resistance.It is most often associated with hyperinsulinemia, which mayresult from insulin receptor gene defects causing insulin resistance, andless frequently due to mutations in fibroblast growth factor receptors.In this work non malignancy-associated AN types will be emphasized,particularly the association of AN with insulin-resistance, itself a potentialthreat to life.http://www.termedia.pl/Prace-Specjalne-Acanthosis-nigricans-a-common-significant-disorder-usually-unassociated-with-malignancy,56,16300,1,0.htmlacanthosis nigricansobesityinsulin resistancefibroblast growth factor receptorsinsulin receptorsdrug eruptions |
| spellingShingle | Edmund J. Janniger Robert A. Schwartz Acanthosis nigricans – a common significant disorder usually unassociated with malignancy Przegląd Dermatologiczny acanthosis nigricans obesity insulin resistance fibroblast growth factor receptors insulin receptors drug eruptions |
| title | Acanthosis nigricans – a common significant disorder usually unassociated with malignancy |
| title_full | Acanthosis nigricans – a common significant disorder usually unassociated with malignancy |
| title_fullStr | Acanthosis nigricans – a common significant disorder usually unassociated with malignancy |
| title_full_unstemmed | Acanthosis nigricans – a common significant disorder usually unassociated with malignancy |
| title_short | Acanthosis nigricans – a common significant disorder usually unassociated with malignancy |
| title_sort | acanthosis nigricans a common significant disorder usually unassociated with malignancy |
| topic | acanthosis nigricans obesity insulin resistance fibroblast growth factor receptors insulin receptors drug eruptions |
| url | http://www.termedia.pl/Prace-Specjalne-Acanthosis-nigricans-a-common-significant-disorder-usually-unassociated-with-malignancy,56,16300,1,0.html |
| work_keys_str_mv | AT edmundjjanniger acanthosisnigricansacommonsignificantdisorderusuallyunassociatedwithmalignancy AT robertaschwartz acanthosisnigricansacommonsignificantdisorderusuallyunassociatedwithmalignancy |