Using Clustered Regularly Interspaced Short Palindromic Repeats gene editing to induce permanent expression of fetal hemoglobin in β-thalassemia and sickle cell disease: A comparative meta-analysis

Using Clustered Regularly Interspaced Short Palindromic Repeats gene editing to induce permanent expression of fetal hemoglobin in β-thalassemia and sickle cell disease: A comparative meta-analysis

β-hemoglobinopathies like sickle cell disease (SCD) and β-thalassemia are characterized by differing mutations in the hemoglobin subunit beta gene (HBB). These disorders vary in phenotypic presentation and severity, with more severe manifestations leading to transfusion dependence along with associa...

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Bibliographic Details
Main Authors: Anthony Quagliano, Daniel Acevedo, Patrik Hardigan, Samiksha Prasad
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Medicine
Subjects:
β-thalassemia
BCL11A
HBG1/2
hemoglobinopathies
fetal hemoglobin (HbF)
gene editing (CRISPR/Cas9)
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.943631/full

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