Limited Independent Follow-Up with Germline Testing of Variants Detected in BRCA1 and BRCA2 by Tumor-Only Sequencing

Limited Independent Follow-Up with Germline Testing of Variants Detected in BRCA1 and BRCA2 by Tumor-Only Sequencing

Introduction Genomic profiling is performed in patients with advanced or metastatic cancer, in order to direct cancer treatment, often sequencing tumor-only, without a matched germline comparator. However, because many of the genes analyzed on tumor profiling overlap with those known to be associate...

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Bibliographic Details
Main Authors: Carol J. Nowlen, Molly Daniels, Burak Uzunparmak, Ecaterina E. Ileana Dumbrava, Ying Yuan, Keyur P. Patel, Nadine Rayes, Jacqueline Harkenrider, Chetna Wathoo, Jennifer Veazie, Krystle A. Luna, Wanlin Wang, Chacha Horombe, Milind Javle, Jordi Rodon Ahnert, Timothy A. Yap, Banu Arun, Karen H. Lu, Funda Meric-Bernstam
Format: Article
Language:English
Published: Innovative Healthcare Institute 2024-02-01
Series:Journal of Immunotherapy and Precision Oncology
Subjects:
brca1
brca2
germline testing
tumor-only testing
Online Access:https://jipo.org/doi/pdf/10.36401/JIPO-23-2

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