Effect of caffeic acid phenethyl ester and Ankaferd Blood Stopper® on palatal wound healing in the diabetic rats
Background/Aim: Caffeic acid phenethyl ester (CAPE) and Ankaferd Blood Stopper® (ABS) are thought to contribute to wound healing. The aim of this study is to investigate the effect of ABS and CAPE on the secondary wound healing of oral mucosal tissue. Materials and Methods: A total of 63 male Spragu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | SRM Journal of Research in Dental Sciences |
| Subjects: | |
| Online Access: | http://www.srmjrds.in/article.asp?issn=0976-433X;year=2020;volume=11;issue=4;spage=172;epage=177;aulast=Gul |
| _version_ | 1811291611480457216 |
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| author | Mehmet Gul Ahmet Günay |
| author_facet | Mehmet Gul Ahmet Günay |
| author_sort | Mehmet Gul |
| collection | DOAJ |
| description | Background/Aim: Caffeic acid phenethyl ester (CAPE) and Ankaferd Blood Stopper® (ABS) are thought to contribute to wound healing. The aim of this study is to investigate the effect of ABS and CAPE on the secondary wound healing of oral mucosal tissue. Materials and Methods: A total of 63 male Sprague-Dawley rats were used in the study. Rats were randomly divided into three groups: ABS group, CAPE group, and control group. Healthy 63 rats were intraperitoneally injected with streptozotocin (Sigma Chemical Co., St. Louis, MO) 50 mg/kg in 0.2 ml 10 m citrate solution. After a week, if the blood glucose value of the rat is ≥250 mg/dl, the rats are considered to be diabetic. General anesthesia of the rats was conducted with intramuscular ketamine (8 mg/100 g). The excisional palatal wound was formed by using a 4 mm punch biopsy tool. Topical ABS was applied to ABS groups; topical CAPE application was applied to CAPE groups. Animals were sacrificed at 7, 14, and 21 days. The palatal specimens were painted with hematoxylin and eosin. The Mann–Whitney U test was used for comparison of the two groups. Results: The results of the statistical analysis determined the vessel dilatation and hemorrhage to be significantly lower in the diabetic ABS and CAPE group than the control group at 7, 14, and 21 days (P < 0.05). Conclusions: In the present study, it is concluded that ABS and CAPE have a positive effect on the wound healing process. |
| first_indexed | 2024-04-13T04:32:29Z |
| format | Article |
| id | doaj.art-1c82e605684b4e18bef23608b7c6c8cb |
| institution | Directory Open Access Journal |
| issn | 2772-5243 2772-5251 |
| language | English |
| last_indexed | 2024-04-13T04:32:29Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | SRM Journal of Research in Dental Sciences |
| spelling | doaj.art-1c82e605684b4e18bef23608b7c6c8cb2022-12-22T03:02:17ZengWolters Kluwer Medknow PublicationsSRM Journal of Research in Dental Sciences2772-52432772-52512020-01-0111417217710.4103/srmjrds.srmjrds_52_20Effect of caffeic acid phenethyl ester and Ankaferd Blood Stopper® on palatal wound healing in the diabetic ratsMehmet GulAhmet GünayBackground/Aim: Caffeic acid phenethyl ester (CAPE) and Ankaferd Blood Stopper® (ABS) are thought to contribute to wound healing. The aim of this study is to investigate the effect of ABS and CAPE on the secondary wound healing of oral mucosal tissue. Materials and Methods: A total of 63 male Sprague-Dawley rats were used in the study. Rats were randomly divided into three groups: ABS group, CAPE group, and control group. Healthy 63 rats were intraperitoneally injected with streptozotocin (Sigma Chemical Co., St. Louis, MO) 50 mg/kg in 0.2 ml 10 m citrate solution. After a week, if the blood glucose value of the rat is ≥250 mg/dl, the rats are considered to be diabetic. General anesthesia of the rats was conducted with intramuscular ketamine (8 mg/100 g). The excisional palatal wound was formed by using a 4 mm punch biopsy tool. Topical ABS was applied to ABS groups; topical CAPE application was applied to CAPE groups. Animals were sacrificed at 7, 14, and 21 days. The palatal specimens were painted with hematoxylin and eosin. The Mann–Whitney U test was used for comparison of the two groups. Results: The results of the statistical analysis determined the vessel dilatation and hemorrhage to be significantly lower in the diabetic ABS and CAPE group than the control group at 7, 14, and 21 days (P < 0.05). Conclusions: In the present study, it is concluded that ABS and CAPE have a positive effect on the wound healing process.http://www.srmjrds.in/article.asp?issn=0976-433X;year=2020;volume=11;issue=4;spage=172;epage=177;aulast=Gulankaferd blood stopper®caffeic acid fenetil esterdiabeticwound healing |
| spellingShingle | Mehmet Gul Ahmet Günay Effect of caffeic acid phenethyl ester and Ankaferd Blood Stopper® on palatal wound healing in the diabetic rats SRM Journal of Research in Dental Sciences ankaferd blood stopper® caffeic acid fenetil ester diabetic wound healing |
| title | Effect of caffeic acid phenethyl ester and Ankaferd Blood Stopper® on palatal wound healing in the diabetic rats |
| title_full | Effect of caffeic acid phenethyl ester and Ankaferd Blood Stopper® on palatal wound healing in the diabetic rats |
| title_fullStr | Effect of caffeic acid phenethyl ester and Ankaferd Blood Stopper® on palatal wound healing in the diabetic rats |
| title_full_unstemmed | Effect of caffeic acid phenethyl ester and Ankaferd Blood Stopper® on palatal wound healing in the diabetic rats |
| title_short | Effect of caffeic acid phenethyl ester and Ankaferd Blood Stopper® on palatal wound healing in the diabetic rats |
| title_sort | effect of caffeic acid phenethyl ester and ankaferd blood stopper r on palatal wound healing in the diabetic rats |
| topic | ankaferd blood stopper® caffeic acid fenetil ester diabetic wound healing |
| url | http://www.srmjrds.in/article.asp?issn=0976-433X;year=2020;volume=11;issue=4;spage=172;epage=177;aulast=Gul |
| work_keys_str_mv | AT mehmetgul effectofcaffeicacidphenethylesterandankaferdbloodstopperonpalatalwoundhealinginthediabeticrats AT ahmetgunay effectofcaffeicacidphenethylesterandankaferdbloodstopperonpalatalwoundhealinginthediabeticrats |