NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues
<p>Abstract</p> <p>Background</p> <p>Clear cell renal cell carcinoma (ccRCC) is the most frequently encountered tumor in the adult kidney. Many factors are known to take part in the development and progression of this tumor. Nuclear factor kappa B (NF-κB) is a family of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2008-10-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Online Access: | http://www.jeccr.com/content/27/1/53 |
| _version_ | 1819086352487022592 |
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| author | Erkus Muhan Meydan Nezih Erdogdu Ibrahim H Meteoglu Ibrahim Barutca Sabri |
| author_facet | Erkus Muhan Meydan Nezih Erdogdu Ibrahim H Meteoglu Ibrahim Barutca Sabri |
| author_sort | Erkus Muhan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Clear cell renal cell carcinoma (ccRCC) is the most frequently encountered tumor in the adult kidney. Many factors are known to take part in the development and progression of this tumor. Nuclear factor kappa B (NF-κB) is a family of the genes that includes five members acting in events such as inflammation and apoptosis. In this study, the role of NF-κB (p50 subunit) in ccRCC and its relation to angiogenesis and apoptosis were investigated.</p> <p>Methods</p> <p>Formalin-fixed and paraffin embedded tissue blocks from 40 patients with ccRCC were studied. Expressions of NF-κB (p50), VEGF, EGFR, bc1-2 and p53 were detected immunohistochemically. The relationship of NF-κB with these markers and clinicopathological findings were evaluated.</p> <p>Results</p> <p>The expression of NF-κB was detected in 35 (85%), VEGF in 37 (92.5%), EGFR in 38 (95%), bc1-2 in 33 (82.5%) and p53 in 13 (32.5%) of 40 ccRCC patients. Statistical analyses revealed a significant relation between NF-κB expression and VEGF (p = 0.001), EGFR (p = 0.004), bc1-2 (p = 0.010) and p53 (p = 0.037). There was no significant correlation between NF-κB and such parameters as tumor grade, stage, age and sex.</p> <p>Conclusion</p> <p>The results of this study indicated that in ccRCC cases NF-κB was associated with markers of angiogenesis and apoptosis such as VEGF, EGFR, bc1-2 and p53. In addition, the results did not only suggest a close relationship between NF-κB and VEGF, EGFR, bc1-2 and p53 in ccRCC, but also indicate that NF-κB was a potential therapeutic target in the treatment of ccRCC resistant to chemotherapy.</p> |
| first_indexed | 2024-12-21T21:18:53Z |
| format | Article |
| id | doaj.art-1c85b08bcab04750b22b7cb2aaa94be3 |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-12-21T21:18:53Z |
| publishDate | 2008-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-1c85b08bcab04750b22b7cb2aaa94be32022-12-21T18:49:56ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662008-10-012715310.1186/1756-9966-27-53NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissuesErkus MuhanMeydan NezihErdogdu Ibrahim HMeteoglu IbrahimBarutca Sabri<p>Abstract</p> <p>Background</p> <p>Clear cell renal cell carcinoma (ccRCC) is the most frequently encountered tumor in the adult kidney. Many factors are known to take part in the development and progression of this tumor. Nuclear factor kappa B (NF-κB) is a family of the genes that includes five members acting in events such as inflammation and apoptosis. In this study, the role of NF-κB (p50 subunit) in ccRCC and its relation to angiogenesis and apoptosis were investigated.</p> <p>Methods</p> <p>Formalin-fixed and paraffin embedded tissue blocks from 40 patients with ccRCC were studied. Expressions of NF-κB (p50), VEGF, EGFR, bc1-2 and p53 were detected immunohistochemically. The relationship of NF-κB with these markers and clinicopathological findings were evaluated.</p> <p>Results</p> <p>The expression of NF-κB was detected in 35 (85%), VEGF in 37 (92.5%), EGFR in 38 (95%), bc1-2 in 33 (82.5%) and p53 in 13 (32.5%) of 40 ccRCC patients. Statistical analyses revealed a significant relation between NF-κB expression and VEGF (p = 0.001), EGFR (p = 0.004), bc1-2 (p = 0.010) and p53 (p = 0.037). There was no significant correlation between NF-κB and such parameters as tumor grade, stage, age and sex.</p> <p>Conclusion</p> <p>The results of this study indicated that in ccRCC cases NF-κB was associated with markers of angiogenesis and apoptosis such as VEGF, EGFR, bc1-2 and p53. In addition, the results did not only suggest a close relationship between NF-κB and VEGF, EGFR, bc1-2 and p53 in ccRCC, but also indicate that NF-κB was a potential therapeutic target in the treatment of ccRCC resistant to chemotherapy.</p>http://www.jeccr.com/content/27/1/53 |
| spellingShingle | Erkus Muhan Meydan Nezih Erdogdu Ibrahim H Meteoglu Ibrahim Barutca Sabri NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues Journal of Experimental & Clinical Cancer Research |
| title | NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues |
| title_full | NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues |
| title_fullStr | NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues |
| title_full_unstemmed | NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues |
| title_short | NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues |
| title_sort | nf kappab expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues |
| url | http://www.jeccr.com/content/27/1/53 |
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