HDAC Inhibitor Abrogates LTA−Induced PAI-1 Expression in Pleural Mesothelial Cells and Attenuates Experimental Pleural Fibrosis

HDAC Inhibitor Abrogates LTA−Induced PAI-1 Expression in Pleural Mesothelial Cells and Attenuates Experimental Pleural Fibrosis

Lipoteichoic acid (LTA) stimulates pleural mesothelial cell (PMC) to overproduce plasminogen activator inhibitor-1 (PAI-1), and thus may promote pleural fibrosis in Gram-positive bacteria (GPB) parapneumonic effusion (PPE). Histone deacetylase inhibitor (HDACi) was found to possess anti-fibrotic pro...

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Bibliographic Details
Main Authors:	Wei-Lin Chen, Mei-Chuan Chen, Shang-Fu Hsu, Shih-Hsin Hsiao, Chi-Li Chung
Format:	Article
Language:	English
Published:	MDPI AG 2021-06-01
Series:	Pharmaceuticals
Subjects:	histone deacetylase inhibitor lipoteichoic acid plasminogen activator inhibitor-1 pleural fibrosis pleural mesothelial cell residual pleural thickening
Online Access:	https://www.mdpi.com/1424-8247/14/6/585

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