Novel roles for protein disulphide isomerase in disease states: a double edged sword?
Protein disulphide isomerase (PDI) is a multifunctional redox chaperone of the endoplasmic reticulum (ER). Since it was first discovered 40 years ago the functions ascribed to PDI have evolved significantly and recent studies have recognized its distinct functions, with adverse as well as protectiv...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00030/full |
| _version_ | 1818962483864403968 |
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| author | Sonam eParakh Julie eAtkin |
| author_facet | Sonam eParakh Julie eAtkin |
| author_sort | Sonam eParakh |
| collection | DOAJ |
| description | Protein disulphide isomerase (PDI) is a multifunctional redox chaperone of the endoplasmic reticulum (ER). Since it was first discovered 40 years ago the functions ascribed to PDI have evolved significantly and recent studies have recognized its distinct functions, with adverse as well as protective effects in disease. Furthermore, post translational modifications of PDI abrogate its normal functional roles in specific disease states. This review focusses on recent studies that have identified novel functions for PDI relevant to specific diseases. |
| first_indexed | 2024-12-20T12:30:03Z |
| format | Article |
| id | doaj.art-1c880c952a65432eaf5c29ee9f8c343c |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-20T12:30:03Z |
| publishDate | 2015-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-1c880c952a65432eaf5c29ee9f8c343c2022-12-21T19:40:45ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2015-05-01310.3389/fcell.2015.00030136498Novel roles for protein disulphide isomerase in disease states: a double edged sword?Sonam eParakh0Julie eAtkin1Macquarie University, SydneyMacquarie University, SydneyProtein disulphide isomerase (PDI) is a multifunctional redox chaperone of the endoplasmic reticulum (ER). Since it was first discovered 40 years ago the functions ascribed to PDI have evolved significantly and recent studies have recognized its distinct functions, with adverse as well as protective effects in disease. Furthermore, post translational modifications of PDI abrogate its normal functional roles in specific disease states. This review focusses on recent studies that have identified novel functions for PDI relevant to specific diseases.http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00030/fullCancerpost-translational modificationsProtein chaperonesprotein disulfide isomerase familyneurodegnerative diseases |
| spellingShingle | Sonam eParakh Julie eAtkin Novel roles for protein disulphide isomerase in disease states: a double edged sword? Frontiers in Cell and Developmental Biology Cancer post-translational modifications Protein chaperones protein disulfide isomerase family neurodegnerative diseases |
| title | Novel roles for protein disulphide isomerase in disease states: a double edged sword? |
| title_full | Novel roles for protein disulphide isomerase in disease states: a double edged sword? |
| title_fullStr | Novel roles for protein disulphide isomerase in disease states: a double edged sword? |
| title_full_unstemmed | Novel roles for protein disulphide isomerase in disease states: a double edged sword? |
| title_short | Novel roles for protein disulphide isomerase in disease states: a double edged sword? |
| title_sort | novel roles for protein disulphide isomerase in disease states a double edged sword |
| topic | Cancer post-translational modifications Protein chaperones protein disulfide isomerase family neurodegnerative diseases |
| url | http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00030/full |
| work_keys_str_mv | AT sonameparakh novelrolesforproteindisulphideisomeraseindiseasestatesadoubleedgedsword AT julieeatkin novelrolesforproteindisulphideisomeraseindiseasestatesadoubleedgedsword |