Novel roles for protein disulphide isomerase in disease states: a double edged sword?

Novel roles for protein disulphide isomerase in disease states: a double edged sword?

Protein disulphide isomerase (PDI) is a multifunctional redox chaperone of the endoplasmic reticulum (ER). Since it was first discovered 40 years ago the functions ascribed to PDI have evolved significantly and recent studies have recognized its distinct functions, with adverse as well as protectiv...

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Bibliographic Details
Main Authors:	Sonam eParakh, Julie eAtkin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2015-05-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	Cancer post-translational modifications Protein chaperones protein disulfide isomerase family neurodegnerative diseases
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00030/full

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