Lack of impact of rotavirus vaccines on seizure-related hospitalizations in children under 5 years old in Spain
Introduction: Up to date the impact of rotavirus (RV) vaccines on seizures has been poorly evaluated, with some studies but not all, showing different degrees of protection. Objectives: To assess the impact of RV vaccines on convulsions-related hospitalizations among children under 5 years of age re...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-06-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2018.1435225 |
| _version_ | 1827809886684053504 |
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| author | Alejandro Orrico-Sánchez Mónica López-Lacort Cintia Muñoz-Quiles Javier Díez-Domingo |
| author_facet | Alejandro Orrico-Sánchez Mónica López-Lacort Cintia Muñoz-Quiles Javier Díez-Domingo |
| author_sort | Alejandro Orrico-Sánchez |
| collection | DOAJ |
| description | Introduction: Up to date the impact of rotavirus (RV) vaccines on seizures has been poorly evaluated, with some studies but not all, showing different degrees of protection. Objectives: To assess the impact of RV vaccines on convulsions-related hospitalizations among children under 5 years of age residing in the Region of Valencia, Spain. Methods: A population-based, ecological study using the hospital discharge record (MBDS), the population-based administrative database (SIP) and the vaccine register (SIV), among Valencia Region's children <5 years old, during 2003 – 2015. Impact of vaccination on seizures-related hospitalization rates (780.3* ICD-9-MC code) was estimated by a multivariate Bayesian mixed Poisson regression model. Results: Since RV vaccines licensure in 2007, its coverage rate increased up to around 42%. When the impact of vaccination against seizures was controlled for potential confounders in the multivariate analysis, there was a non-statistically significant protective effect. Conclusions: We could not find any impact of RV vaccine coverage on seizure-related hospitalizations in children <5 years. |
| first_indexed | 2024-03-11T22:45:27Z |
| format | Article |
| id | doaj.art-1c882c1410004d40be485fb679a29748 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:45:27Z |
| publishDate | 2018-06-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-1c882c1410004d40be485fb679a297482023-09-22T08:17:54ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2018-06-011461534153810.1080/21645515.2018.14352251435225Lack of impact of rotavirus vaccines on seizure-related hospitalizations in children under 5 years old in SpainAlejandro Orrico-Sánchez0Mónica López-Lacort1Cintia Muñoz-Quiles2Javier Díez-Domingo3Vaccine Research, Fundación para el Fomento de la Investigación Sanitaria y, Biomédica de la Comunitat Valenciana, FISABIO-Public HealthVaccine Research, Fundación para el Fomento de la Investigación Sanitaria y, Biomédica de la Comunitat Valenciana, FISABIO-Public HealthVaccine Research, Fundación para el Fomento de la Investigación Sanitaria y, Biomédica de la Comunitat Valenciana, FISABIO-Public HealthVaccine Research, Fundación para el Fomento de la Investigación Sanitaria y, Biomédica de la Comunitat Valenciana, FISABIO-Public HealthIntroduction: Up to date the impact of rotavirus (RV) vaccines on seizures has been poorly evaluated, with some studies but not all, showing different degrees of protection. Objectives: To assess the impact of RV vaccines on convulsions-related hospitalizations among children under 5 years of age residing in the Region of Valencia, Spain. Methods: A population-based, ecological study using the hospital discharge record (MBDS), the population-based administrative database (SIP) and the vaccine register (SIV), among Valencia Region's children <5 years old, during 2003 – 2015. Impact of vaccination on seizures-related hospitalization rates (780.3* ICD-9-MC code) was estimated by a multivariate Bayesian mixed Poisson regression model. Results: Since RV vaccines licensure in 2007, its coverage rate increased up to around 42%. When the impact of vaccination against seizures was controlled for potential confounders in the multivariate analysis, there was a non-statistically significant protective effect. Conclusions: We could not find any impact of RV vaccine coverage on seizure-related hospitalizations in children <5 years.http://dx.doi.org/10.1080/21645515.2018.1435225childhospitalizationimpactrotavirusseizuresspainvaccines |
| spellingShingle | Alejandro Orrico-Sánchez Mónica López-Lacort Cintia Muñoz-Quiles Javier Díez-Domingo Lack of impact of rotavirus vaccines on seizure-related hospitalizations in children under 5 years old in Spain Human Vaccines & Immunotherapeutics child hospitalization impact rotavirus seizures spain vaccines |
| title | Lack of impact of rotavirus vaccines on seizure-related hospitalizations in children under 5 years old in Spain |
| title_full | Lack of impact of rotavirus vaccines on seizure-related hospitalizations in children under 5 years old in Spain |
| title_fullStr | Lack of impact of rotavirus vaccines on seizure-related hospitalizations in children under 5 years old in Spain |
| title_full_unstemmed | Lack of impact of rotavirus vaccines on seizure-related hospitalizations in children under 5 years old in Spain |
| title_short | Lack of impact of rotavirus vaccines on seizure-related hospitalizations in children under 5 years old in Spain |
| title_sort | lack of impact of rotavirus vaccines on seizure related hospitalizations in children under 5 years old in spain |
| topic | child hospitalization impact rotavirus seizures spain vaccines |
| url | http://dx.doi.org/10.1080/21645515.2018.1435225 |
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