Malnutrition and infection lead to poor prognosis and heavy financial burden of patients with chronic heart failure
BackgroundChronic heart failure (CHF) is a major public health concern, as it is associated with poor prognosis and heavy financial burden. In recent years, there has been increasing interest in medications for CHF in China, but few studies pay attention to the effects of nutrition and infection.Met...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1045262/full |
| _version_ | 1798014603278417920 |
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| author | Xu Jia Xing-long Yu Bin Lu Yuan-yuan Shang Long-fei Shen Yu-lin Li Wei Zhang Ming Zhong Lu Han Lu Han Zhi-Hao Wang Zhi-Hao Wang |
| author_facet | Xu Jia Xing-long Yu Bin Lu Yuan-yuan Shang Long-fei Shen Yu-lin Li Wei Zhang Ming Zhong Lu Han Lu Han Zhi-Hao Wang Zhi-Hao Wang |
| author_sort | Xu Jia |
| collection | DOAJ |
| description | BackgroundChronic heart failure (CHF) is a major public health concern, as it is associated with poor prognosis and heavy financial burden. In recent years, there has been increasing interest in medications for CHF in China, but few studies pay attention to the effects of nutrition and infection.Methods and resultsThis was a retrospective study collected patients with CHF admitted to the Department of Cardiology of Qilu Hospital of Shandong University from January 2017 to May 2018. Patients were classified according to the prognosis and the financial burden. Through comparison and regression analysis, we found that the factor associated with worse prognosis were decreased heart rate, albumin and prealbumin; β-blockers and mineralocorticoid receptor antagonism (MRA) were the factor improved the prognosis of patients with CHF; the factor overburdening financial condition were infection, decreased prealbumin, high Alanine aminotransferase (ALT), usage of recombinant human brain natriuretic peptide (rhBNP) and Levosimendan; aspirin and Sacubitril/Valsartan were the factor releasing financial burden of patients with CHF. Then, we grouped by Controlling Nutritional Status (CONUT) score, which enabled evaluation of the patient's protein reserve and immune defenses. Patients in the malnutrition group had higher infection ratios, longer hospital stays, and greater hospital expenses than the normal group. The improvement ratios of therapeutic outcomes in the moderate or severe malnutrition group were lower than in the normal and mild malnutrition group.ConclusionMalnutrition and infection caused poor prognosis and increased financial burden of patients with CHF. The high CONUT score indicated the CHF patient's unfavorable prognosis and heavy financial burden. |
| first_indexed | 2024-04-11T15:20:00Z |
| format | Article |
| id | doaj.art-1c886a6f0fc74285a4761a6a752bd41b |
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| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-11T15:20:00Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-1c886a6f0fc74285a4761a6a752bd41b2022-12-22T04:16:23ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-12-01910.3389/fcvm.2022.10452621045262Malnutrition and infection lead to poor prognosis and heavy financial burden of patients with chronic heart failureXu Jia0Xing-long Yu1Bin Lu2Yuan-yuan Shang3Long-fei Shen4Yu-lin Li5Wei Zhang6Ming Zhong7Lu Han8Lu Han9Zhi-Hao Wang10Zhi-Hao Wang11The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Cheeloo College of Medicine, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaDepartment of Cardiology, People's Hospital of Lixia District of Jinan, Jinan, Shandong, ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Cheeloo College of Medicine, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Cheeloo College of Medicine, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Cheeloo College of Medicine, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Cheeloo College of Medicine, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Cheeloo College of Medicine, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Cheeloo College of Medicine, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Cheeloo College of Medicine, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaDepartment of General Practice, Qilu Hospital of Shandong University, Jinan, ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Cheeloo College of Medicine, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaDepartment of Geriatric Medicine, Shandong Key Laboratory of Cardiovascular Proteomics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaBackgroundChronic heart failure (CHF) is a major public health concern, as it is associated with poor prognosis and heavy financial burden. In recent years, there has been increasing interest in medications for CHF in China, but few studies pay attention to the effects of nutrition and infection.Methods and resultsThis was a retrospective study collected patients with CHF admitted to the Department of Cardiology of Qilu Hospital of Shandong University from January 2017 to May 2018. Patients were classified according to the prognosis and the financial burden. Through comparison and regression analysis, we found that the factor associated with worse prognosis were decreased heart rate, albumin and prealbumin; β-blockers and mineralocorticoid receptor antagonism (MRA) were the factor improved the prognosis of patients with CHF; the factor overburdening financial condition were infection, decreased prealbumin, high Alanine aminotransferase (ALT), usage of recombinant human brain natriuretic peptide (rhBNP) and Levosimendan; aspirin and Sacubitril/Valsartan were the factor releasing financial burden of patients with CHF. Then, we grouped by Controlling Nutritional Status (CONUT) score, which enabled evaluation of the patient's protein reserve and immune defenses. Patients in the malnutrition group had higher infection ratios, longer hospital stays, and greater hospital expenses than the normal group. The improvement ratios of therapeutic outcomes in the moderate or severe malnutrition group were lower than in the normal and mild malnutrition group.ConclusionMalnutrition and infection caused poor prognosis and increased financial burden of patients with CHF. The high CONUT score indicated the CHF patient's unfavorable prognosis and heavy financial burden.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1045262/fullchronic heart failuremalnutritioninfectionCONUT scoreprognosisfinancial burden |
| spellingShingle | Xu Jia Xing-long Yu Bin Lu Yuan-yuan Shang Long-fei Shen Yu-lin Li Wei Zhang Ming Zhong Lu Han Lu Han Zhi-Hao Wang Zhi-Hao Wang Malnutrition and infection lead to poor prognosis and heavy financial burden of patients with chronic heart failure Frontiers in Cardiovascular Medicine chronic heart failure malnutrition infection CONUT score prognosis financial burden |
| title | Malnutrition and infection lead to poor prognosis and heavy financial burden of patients with chronic heart failure |
| title_full | Malnutrition and infection lead to poor prognosis and heavy financial burden of patients with chronic heart failure |
| title_fullStr | Malnutrition and infection lead to poor prognosis and heavy financial burden of patients with chronic heart failure |
| title_full_unstemmed | Malnutrition and infection lead to poor prognosis and heavy financial burden of patients with chronic heart failure |
| title_short | Malnutrition and infection lead to poor prognosis and heavy financial burden of patients with chronic heart failure |
| title_sort | malnutrition and infection lead to poor prognosis and heavy financial burden of patients with chronic heart failure |
| topic | chronic heart failure malnutrition infection CONUT score prognosis financial burden |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1045262/full |
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