Interleukin-10 Delays Viral Clearance in the Placenta and Uterus of Mice With Acute Lymphocytic Choriomeningitis Virus Infection During Pregnancy

Interleukin-10 Delays Viral Clearance in the Placenta and Uterus of Mice With Acute Lymphocytic Choriomeningitis Virus Infection During Pregnancy

Pregnant mice infected with Lymphocytic Choriomeningitis Virus (Armstrong) (LCMV-Arm) experience high viral loads in the placenta and uterine tissue by 5–8 days post-infection, a time when the virus is nearly completely cleared from the spleen and blood. Interleukin 10 (IL-10) plays a crucial role i...

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Bibliographic Details
Main Authors: Vidya Devi Negi, Sandhya Khurana, Elizabeth A. Bonney
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Virology
Subjects:
CD8 T cells
cytokines
pregnancy
lymphocytic choriomeningitis (LCMV)
mouse
Online Access:https://www.frontiersin.org/articles/10.3389/fviro.2022.829991/full

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