Gastric antral vascular ectasia in hepatitis C virus related liver cirrhosis: Fetching for predictors
Abstract Background and Aim Gastric antral vascular ectasia (GAVE) is observed in patients with liver cirrhosis and portal hypertension. The exact pathophysiologic mechanism that underlies this condition is unknown. In our study, we estimate the prevalence of GAVE in hepatitis C virus (HCV) cirrhosi...
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| Format: | Article |
| Language: | English |
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Wiley
2021-08-01
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| Series: | JGH Open |
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| Online Access: | https://doi.org/10.1002/jgh3.12607 |
| _version_ | 1819018842189332480 |
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| author | Magdy Fouad Hanaa Khalaf Fath‐Elbab Alaa Mohamed Mostafa Hend M Moness Nashwa Mohamed Adel Elham Ahmed |
| author_facet | Magdy Fouad Hanaa Khalaf Fath‐Elbab Alaa Mohamed Mostafa Hend M Moness Nashwa Mohamed Adel Elham Ahmed |
| author_sort | Magdy Fouad |
| collection | DOAJ |
| description | Abstract Background and Aim Gastric antral vascular ectasia (GAVE) is observed in patients with liver cirrhosis and portal hypertension. The exact pathophysiologic mechanism that underlies this condition is unknown. In our study, we estimate the prevalence of GAVE in hepatitis C virus (HCV) cirrhosis and attempted to determine if any of the hepatocellular manifestations, liver functions, serum gastrin, abdominal ultrasound and endoscopic picture have a relation to, or could predict, the occurrence of GAVE in cirrhotic patients. Methods This study includes 500 HCV‐related liver cirrhosis patients. According to endoscopic assessment, we detected 30 patients with GAVE (Group 2). From the 470 patients without GAVE, we randomly selected 120 patients (Group 1), to avoid statistical bias, for comparison with Group 2. Comparison included clinical manifestations, laboratory findings, serum gastrin, ultrasound findings, and endoscopic findings (esophageal and/or gastric varices and gastropathy). Results The percentage of GAVE in HCV‐related liver cirrhosis is 0.06%. We can predict GAVE by platelets, palmer erythema, diabetes mellitus (DM), marked ascites > with area under the curve of 0.67, 75.5, 0.62, and 0.40%, and accuracy of 82.5, 72, 70.7, and 79.3%, respectively. There was no correlation found between occurrence of GAVE and endoscopic findings. Also, there was no correlation found between occurrence of GAVE and serum gastrin levels, which reflect another pathophysiology, and we found no statistically significant correlation with GAVE. Conclusions Palmer erythema, low platelets, DM, and ascites might help in the prediction of GAVE. GAVE is not linked to the presence, type or grade of varices, and gastropathy. |
| first_indexed | 2024-12-21T03:25:50Z |
| format | Article |
| id | doaj.art-1c8890166a5a49d5809a49102f721742 |
| institution | Directory Open Access Journal |
| issn | 2397-9070 |
| language | English |
| last_indexed | 2024-12-21T03:25:50Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | JGH Open |
| spelling | doaj.art-1c8890166a5a49d5809a49102f7217422022-12-21T19:17:36ZengWileyJGH Open2397-90702021-08-015892392810.1002/jgh3.12607Gastric antral vascular ectasia in hepatitis C virus related liver cirrhosis: Fetching for predictorsMagdy Fouad0Hanaa Khalaf Fath‐Elbab1Alaa Mohamed Mostafa2Hend M Moness3Nashwa Mohamed Adel4Elham Ahmed5Gastroenterology and Hepatology Unit, Department of Tropical Medicine Faculty of Medicine ‐ Minia University Minia EgyptGastroenterology and Hepatology Unit, Department of Tropical Medicine Faculty of Medicine ‐ Minia University Minia EgyptGastroenterology and Hepatology Unit, Department of Tropical Medicine Faculty of Medicine ‐ Minia University Minia EgyptDepartment of Clinical Pathology Faculty of Medicine ‐ Minia University Minia EgyptDepartment of Radiology Faculty of Medicine ‐ Minia University Minia EgyptDepartment of Internal Medicine Faculty of Medicine ‐ Minia University Minia EgyptAbstract Background and Aim Gastric antral vascular ectasia (GAVE) is observed in patients with liver cirrhosis and portal hypertension. The exact pathophysiologic mechanism that underlies this condition is unknown. In our study, we estimate the prevalence of GAVE in hepatitis C virus (HCV) cirrhosis and attempted to determine if any of the hepatocellular manifestations, liver functions, serum gastrin, abdominal ultrasound and endoscopic picture have a relation to, or could predict, the occurrence of GAVE in cirrhotic patients. Methods This study includes 500 HCV‐related liver cirrhosis patients. According to endoscopic assessment, we detected 30 patients with GAVE (Group 2). From the 470 patients without GAVE, we randomly selected 120 patients (Group 1), to avoid statistical bias, for comparison with Group 2. Comparison included clinical manifestations, laboratory findings, serum gastrin, ultrasound findings, and endoscopic findings (esophageal and/or gastric varices and gastropathy). Results The percentage of GAVE in HCV‐related liver cirrhosis is 0.06%. We can predict GAVE by platelets, palmer erythema, diabetes mellitus (DM), marked ascites > with area under the curve of 0.67, 75.5, 0.62, and 0.40%, and accuracy of 82.5, 72, 70.7, and 79.3%, respectively. There was no correlation found between occurrence of GAVE and endoscopic findings. Also, there was no correlation found between occurrence of GAVE and serum gastrin levels, which reflect another pathophysiology, and we found no statistically significant correlation with GAVE. Conclusions Palmer erythema, low platelets, DM, and ascites might help in the prediction of GAVE. GAVE is not linked to the presence, type or grade of varices, and gastropathy.https://doi.org/10.1002/jgh3.12607gastric antral vascular ectasiagastringastropathyhepatitis C virusliver cirrhosisvarices |
| spellingShingle | Magdy Fouad Hanaa Khalaf Fath‐Elbab Alaa Mohamed Mostafa Hend M Moness Nashwa Mohamed Adel Elham Ahmed Gastric antral vascular ectasia in hepatitis C virus related liver cirrhosis: Fetching for predictors JGH Open gastric antral vascular ectasia gastrin gastropathy hepatitis C virus liver cirrhosis varices |
| title | Gastric antral vascular ectasia in hepatitis C virus related liver cirrhosis: Fetching for predictors |
| title_full | Gastric antral vascular ectasia in hepatitis C virus related liver cirrhosis: Fetching for predictors |
| title_fullStr | Gastric antral vascular ectasia in hepatitis C virus related liver cirrhosis: Fetching for predictors |
| title_full_unstemmed | Gastric antral vascular ectasia in hepatitis C virus related liver cirrhosis: Fetching for predictors |
| title_short | Gastric antral vascular ectasia in hepatitis C virus related liver cirrhosis: Fetching for predictors |
| title_sort | gastric antral vascular ectasia in hepatitis c virus related liver cirrhosis fetching for predictors |
| topic | gastric antral vascular ectasia gastrin gastropathy hepatitis C virus liver cirrhosis varices |
| url | https://doi.org/10.1002/jgh3.12607 |
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