Altered voxel-level whole-brain functional connectivity in multiple system atrophy patients with depression symptoms
Abstract Background It is yet unknown if the whole-brain resting-state network is altered in multiple system atrophy with symptoms of depression. This study aimed to investigate if and how depression symptoms in multiple system atrophy are associated with resting-state network dysfunction. Methods W...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12888-022-03893-4 |
| _version_ | 1818060716578439168 |
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| author | Hua Guang Yang Weiyin Vivian Liu Zhi Wen Lan Hua Hu Guo Guang Fan Yun Fei Zha |
| author_facet | Hua Guang Yang Weiyin Vivian Liu Zhi Wen Lan Hua Hu Guo Guang Fan Yun Fei Zha |
| author_sort | Hua Guang Yang |
| collection | DOAJ |
| description | Abstract Background It is yet unknown if the whole-brain resting-state network is altered in multiple system atrophy with symptoms of depression. This study aimed to investigate if and how depression symptoms in multiple system atrophy are associated with resting-state network dysfunction. Methods We assessed the resting-state functional network matric using Degree centrality (DC) coupling with a second ROI-wise functional connectivity (FC) algorithm in a multimodal imaging case-control study that enrolled 32 multiple system atrophy patients with depression symptoms (MSA-D), 30 multiple system atrophy patients without depression symptoms (MSA-ND), and 34 healthy controls (HC). Results Compared to HC, MSA-D showed more extensive DC hub dysfunction in the left precentral and right middle frontal cortex than MSA-ND. A direct comparison between MSA-D and MSA-ND detected increased DC in the right anterior cingulum cortex, but decreased DC in the left cerebellum lobule IV and lobule V, left middle pole temporal cortex, and right superior frontal cortex. Only right anterior cingulum cortex mean DC values showed a positive correlation with depression severity, and used ACC as seed, a second ROI-wise functional connectivity further revealed MSA-D patients showed decreased connectivity between the ACC and right thalamus and right middle temporal gyrus (MTG). Conclusions These findings revealed that dysfunction of rACC, right middle temporal lobe and right thalamus involved in depressed MSA. Our study might help to the understanding of the neuropathological mechanism of depression in MSA. |
| first_indexed | 2024-12-10T13:36:51Z |
| format | Article |
| id | doaj.art-1c8908df64814972b711e2324b0f3ba7 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-10T13:36:51Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-1c8908df64814972b711e2324b0f3ba72022-12-22T01:46:47ZengBMCBMC Psychiatry1471-244X2022-04-0122111110.1186/s12888-022-03893-4Altered voxel-level whole-brain functional connectivity in multiple system atrophy patients with depression symptomsHua Guang Yang0Weiyin Vivian Liu1Zhi Wen2Lan Hua Hu3Guo Guang Fan4Yun Fei Zha5Department of Radiology, Renmin Hospital of Wuhan UniversityMR Research, GE HealthcareDepartment of Radiology, Renmin Hospital of Wuhan UniversityDepartment of Radiology, Renmin Hospital of Wuhan UniversityDepartment of Radiology, The First Affiliated Hospital of China Medical UniversityDepartment of Radiology, Renmin Hospital of Wuhan UniversityAbstract Background It is yet unknown if the whole-brain resting-state network is altered in multiple system atrophy with symptoms of depression. This study aimed to investigate if and how depression symptoms in multiple system atrophy are associated with resting-state network dysfunction. Methods We assessed the resting-state functional network matric using Degree centrality (DC) coupling with a second ROI-wise functional connectivity (FC) algorithm in a multimodal imaging case-control study that enrolled 32 multiple system atrophy patients with depression symptoms (MSA-D), 30 multiple system atrophy patients without depression symptoms (MSA-ND), and 34 healthy controls (HC). Results Compared to HC, MSA-D showed more extensive DC hub dysfunction in the left precentral and right middle frontal cortex than MSA-ND. A direct comparison between MSA-D and MSA-ND detected increased DC in the right anterior cingulum cortex, but decreased DC in the left cerebellum lobule IV and lobule V, left middle pole temporal cortex, and right superior frontal cortex. Only right anterior cingulum cortex mean DC values showed a positive correlation with depression severity, and used ACC as seed, a second ROI-wise functional connectivity further revealed MSA-D patients showed decreased connectivity between the ACC and right thalamus and right middle temporal gyrus (MTG). Conclusions These findings revealed that dysfunction of rACC, right middle temporal lobe and right thalamus involved in depressed MSA. Our study might help to the understanding of the neuropathological mechanism of depression in MSA.https://doi.org/10.1186/s12888-022-03893-4Multiple system atrophyDepression symptomsFunctional magnetic resonance imagingDegree centralityFunctional connectivity |
| spellingShingle | Hua Guang Yang Weiyin Vivian Liu Zhi Wen Lan Hua Hu Guo Guang Fan Yun Fei Zha Altered voxel-level whole-brain functional connectivity in multiple system atrophy patients with depression symptoms BMC Psychiatry Multiple system atrophy Depression symptoms Functional magnetic resonance imaging Degree centrality Functional connectivity |
| title | Altered voxel-level whole-brain functional connectivity in multiple system atrophy patients with depression symptoms |
| title_full | Altered voxel-level whole-brain functional connectivity in multiple system atrophy patients with depression symptoms |
| title_fullStr | Altered voxel-level whole-brain functional connectivity in multiple system atrophy patients with depression symptoms |
| title_full_unstemmed | Altered voxel-level whole-brain functional connectivity in multiple system atrophy patients with depression symptoms |
| title_short | Altered voxel-level whole-brain functional connectivity in multiple system atrophy patients with depression symptoms |
| title_sort | altered voxel level whole brain functional connectivity in multiple system atrophy patients with depression symptoms |
| topic | Multiple system atrophy Depression symptoms Functional magnetic resonance imaging Degree centrality Functional connectivity |
| url | https://doi.org/10.1186/s12888-022-03893-4 |
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