Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization
Radiotherapy is the main treatment for most cancer, but it is unclear if targeting tumour vasculature can enhance tumour radiosensitivity. Here, the authors show that tumour endothelial-mesenchymal transition after radiotherapy leads to proliferation of radioresistant CSCs and tumour associated macr...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07470-w |
| _version_ | 1818835049586360320 |
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| author | Seo-Hyun Choi A-Ram Kim Jae-Kyung Nam Jin-Mo Kim Jee-Youn Kim Haeng Ran Seo Hae-June Lee Jaeho Cho Yoon-Jin Lee |
| author_facet | Seo-Hyun Choi A-Ram Kim Jae-Kyung Nam Jin-Mo Kim Jee-Youn Kim Haeng Ran Seo Hae-June Lee Jaeho Cho Yoon-Jin Lee |
| author_sort | Seo-Hyun Choi |
| collection | DOAJ |
| description | Radiotherapy is the main treatment for most cancer, but it is unclear if targeting tumour vasculature can enhance tumour radiosensitivity. Here, the authors show that tumour endothelial-mesenchymal transition after radiotherapy leads to proliferation of radioresistant CSCs and tumour associated macrophages polarization. |
| first_indexed | 2024-12-19T02:44:32Z |
| format | Article |
| id | doaj.art-1c8be8c45157487b80a64a318466f67b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T02:44:32Z |
| publishDate | 2018-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1c8be8c45157487b80a64a318466f67b2022-12-21T20:38:58ZengNature PortfolioNature Communications2041-17232018-11-019111810.1038/s41467-018-07470-wTumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarizationSeo-Hyun Choi0A-Ram Kim1Jae-Kyung Nam2Jin-Mo Kim3Jee-Youn Kim4Haeng Ran Seo5Hae-June Lee6Jaeho Cho7Yoon-Jin Lee8Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical SciencesDivision of Radiation Biomedical Research, Korea Institute of Radiological & Medical SciencesDivision of Radiation Biomedical Research, Korea Institute of Radiological & Medical SciencesDepartment of Radiation Oncology, Yonsei University College of MedicineDepartment of Radiation Oncology, Yonsei University College of MedicineCancer Biology Research Laboratory, Institute Pasteur KoreaDivision of Radiation Biomedical Research, Korea Institute of Radiological & Medical SciencesDepartment of Radiation Oncology, Yonsei University College of MedicineDivision of Radiation Biomedical Research, Korea Institute of Radiological & Medical SciencesRadiotherapy is the main treatment for most cancer, but it is unclear if targeting tumour vasculature can enhance tumour radiosensitivity. Here, the authors show that tumour endothelial-mesenchymal transition after radiotherapy leads to proliferation of radioresistant CSCs and tumour associated macrophages polarization.https://doi.org/10.1038/s41467-018-07470-w |
| spellingShingle | Seo-Hyun Choi A-Ram Kim Jae-Kyung Nam Jin-Mo Kim Jee-Youn Kim Haeng Ran Seo Hae-June Lee Jaeho Cho Yoon-Jin Lee Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization Nature Communications |
| title | Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization |
| title_full | Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization |
| title_fullStr | Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization |
| title_full_unstemmed | Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization |
| title_short | Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization |
| title_sort | tumour vasculature development via endothelial to mesenchymal transition after radiotherapy controls cd44v6 cancer cell and macrophage polarization |
| url | https://doi.org/10.1038/s41467-018-07470-w |
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