Mycobacterium gordonae infection in immunocompromised and immunocompetent hosts: A series of seven cases and literature review
Background/purpose: Mycobacterium gordonae is a ubiquitous environmental mycobacteria and has been long considered an opportunistic pathogen, causing infections only in immunocompromised hosts. Cases of M. gordonae related infections in immunocompetent host have rarely been reported, and the pathoge...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664620302898 |
| _version_ | 1818955896769740800 |
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| author | Hao-Yun Chang Wan-Chen Tsai Tai-Fen Lee Wang-Huei Sheng |
| author_facet | Hao-Yun Chang Wan-Chen Tsai Tai-Fen Lee Wang-Huei Sheng |
| author_sort | Hao-Yun Chang |
| collection | DOAJ |
| description | Background/purpose: Mycobacterium gordonae is a ubiquitous environmental mycobacteria and has been long considered an opportunistic pathogen, causing infections only in immunocompromised hosts. Cases of M. gordonae related infections in immunocompetent host have rarely been reported, and the pathogenicity of M. gordonae remained uncertain. Methods: From January 2016 to December 2018, seven cases of M. gordonae infection were diagnosed and treated at National Taiwan University Hospital. Results: Six cases had at least one underlying disease affecting immune status, while one case had no identifiable underlying disease. The sites of infection were lung (n = 3), skin and soft tissue (n = 3), and one had disseminated disease involving the lung and bone marrow. All patients were cured after anti-mycobacterial treatment, except one patient died of refractory leukemia. Conclusion: Compatible with the literature reports, we demonstrate that M. gordonae could be pathogenic and causing infection not only in the immunocompromised host, but also in the otherwise healthy population. Multi-antimicrobial combination and adequate source control could have good therapeutic effect for patients with M. gordonae infections |
| first_indexed | 2024-12-20T10:45:21Z |
| format | Article |
| id | doaj.art-1c8f857a27d8498c861c3aca9e7e4408 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-20T10:45:21Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-1c8f857a27d8498c861c3aca9e7e44082022-12-21T19:43:24ZengElsevierJournal of the Formosan Medical Association0929-66462021-01-011201524532Mycobacterium gordonae infection in immunocompromised and immunocompetent hosts: A series of seven cases and literature reviewHao-Yun Chang0Wan-Chen Tsai1Tai-Fen Lee2Wang-Huei Sheng3Departments of Internal Medicine, National Taiwan University Hospital, Taipei, TaiwanDepartments of Internal Medicine, National Taiwan University Hospital, Taipei, TaiwanDepartments of Laboratory Medicine, National Taiwan University Hospital, Taipei, TaiwanDepartments of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; School of Medicine, National Taiwan University, Taipei, Taiwan; Corresponding author. Department of Internal Medicine, National Taiwan University Hospital, No.7, Jhongshan S. Rd., Jhongjheng Dist., Taipei, 10002, Taiwan.Background/purpose: Mycobacterium gordonae is a ubiquitous environmental mycobacteria and has been long considered an opportunistic pathogen, causing infections only in immunocompromised hosts. Cases of M. gordonae related infections in immunocompetent host have rarely been reported, and the pathogenicity of M. gordonae remained uncertain. Methods: From January 2016 to December 2018, seven cases of M. gordonae infection were diagnosed and treated at National Taiwan University Hospital. Results: Six cases had at least one underlying disease affecting immune status, while one case had no identifiable underlying disease. The sites of infection were lung (n = 3), skin and soft tissue (n = 3), and one had disseminated disease involving the lung and bone marrow. All patients were cured after anti-mycobacterial treatment, except one patient died of refractory leukemia. Conclusion: Compatible with the literature reports, we demonstrate that M. gordonae could be pathogenic and causing infection not only in the immunocompromised host, but also in the otherwise healthy population. Multi-antimicrobial combination and adequate source control could have good therapeutic effect for patients with M. gordonae infectionshttp://www.sciencedirect.com/science/article/pii/S0929664620302898Mycobacterium gordonaeNon-tuberculous mycobacteriaImmunocompromised hostTherapeuticsPrognosis |
| spellingShingle | Hao-Yun Chang Wan-Chen Tsai Tai-Fen Lee Wang-Huei Sheng Mycobacterium gordonae infection in immunocompromised and immunocompetent hosts: A series of seven cases and literature review Journal of the Formosan Medical Association Mycobacterium gordonae Non-tuberculous mycobacteria Immunocompromised host Therapeutics Prognosis |
| title | Mycobacterium gordonae infection in immunocompromised and immunocompetent hosts: A series of seven cases and literature review |
| title_full | Mycobacterium gordonae infection in immunocompromised and immunocompetent hosts: A series of seven cases and literature review |
| title_fullStr | Mycobacterium gordonae infection in immunocompromised and immunocompetent hosts: A series of seven cases and literature review |
| title_full_unstemmed | Mycobacterium gordonae infection in immunocompromised and immunocompetent hosts: A series of seven cases and literature review |
| title_short | Mycobacterium gordonae infection in immunocompromised and immunocompetent hosts: A series of seven cases and literature review |
| title_sort | mycobacterium gordonae infection in immunocompromised and immunocompetent hosts a series of seven cases and literature review |
| topic | Mycobacterium gordonae Non-tuberculous mycobacteria Immunocompromised host Therapeutics Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S0929664620302898 |
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