Design, Synthesis, and In Silico Multitarget Pharmacological Simulations of Acid Bioisosteres with a Validated In Vivo Antihyperglycemic Effect

Design, Synthesis, and In Silico Multitarget Pharmacological Simulations of Acid Bioisosteres with a Validated In Vivo Antihyperglycemic Effect

Substituted phenylacetic (<b>1–3</b>), phenylpropanoic (<b>4–6</b>), and benzylidenethiazolidine-2,4-dione (<b>7–9</b>) derivatives were designed according to a multitarget unified pharmacophore pattern that has shown robust antidiabetic activity. This bioactivity...

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Bibliographic Details
Main Authors: Elix Alberto Domínguez-Mendoza, Yelzyn Galván-Ciprés, Josué Martínez-Miranda, Cristian Miranda-González, Blanca Colín-Lozano, Emanuel Hernández-Núñez, Gloria I. Hernández-Bolio, Oscar Palomino-Hernández, Gabriel Navarrete-Vazquez
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Molecules
Subjects:
multitarget ligands
drug design
diabetes
molecular dynamics
Online Access:https://www.mdpi.com/1420-3049/26/4/799

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https://www.mdpi.com/1420-3049/26/4/799

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