Intranasal Delivery of Thermostable Subunit Vaccine for Cross-Reactive Mucosal and Systemic Antibody Responses Against SARS-CoV-2

Intranasal Delivery of Thermostable Subunit Vaccine for Cross-Reactive Mucosal and Systemic Antibody Responses Against SARS-CoV-2

Despite the remarkable efficacy of currently approved COVID-19 vaccines, there are several opportunities for continued vaccine development against SARS-CoV-2 and future lethal respiratory viruses. In particular, restricted vaccine access and hesitancy have limited immunization rates. In addition, cu...

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Bibliographic Details
Main Authors: Khue G. Nguyen, Siena M. Mantooth, Maura R. Vrabel, David A. Zaharoff
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
Intranasal vaccination
COVID-19
mucosal immunity
SARS-CoV-2
Receptor binding domain (RBD)
chitosan
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.858904/full

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