Vascular control of the Drosophila haematopoietic microenvironment by Slit/Robo signalling

The posterior signalling centre (PSC) in Drosophilalarva regulates blood cell differentiation but it is unclear how this is controlled. Here, the authors show that Slit/Robo signalling from the vascular system regulates PSC morphology and function, in turn, regulating blood cell differentiation.

Bibliographic Details
Main Authors: Ismaël Morin-Poulard, Anurag Sharma, Isabelle Louradour, Nathalie Vanzo, Alain Vincent, Michèle Crozatier
Format: Article
Language:English
Published: Nature Portfolio 2016-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11634
_version_ 1818996737697644544
author Ismaël Morin-Poulard
Anurag Sharma
Isabelle Louradour
Nathalie Vanzo
Alain Vincent
Michèle Crozatier
author_facet Ismaël Morin-Poulard
Anurag Sharma
Isabelle Louradour
Nathalie Vanzo
Alain Vincent
Michèle Crozatier
author_sort Ismaël Morin-Poulard
collection DOAJ
description The posterior signalling centre (PSC) in Drosophilalarva regulates blood cell differentiation but it is unclear how this is controlled. Here, the authors show that Slit/Robo signalling from the vascular system regulates PSC morphology and function, in turn, regulating blood cell differentiation.
first_indexed 2024-12-20T21:34:30Z
format Article
id doaj.art-1c95b05837744bfb878843dce508918f
institution Directory Open Access Journal
issn 2041-1723
language English
last_indexed 2024-12-20T21:34:30Z
publishDate 2016-05-01
publisher Nature Portfolio
record_format Article
series Nature Communications
spelling doaj.art-1c95b05837744bfb878843dce508918f2022-12-21T19:25:59ZengNature PortfolioNature Communications2041-17232016-05-017111210.1038/ncomms11634Vascular control of the Drosophila haematopoietic microenvironment by Slit/Robo signallingIsmaël Morin-Poulard0Anurag Sharma1Isabelle Louradour2Nathalie Vanzo3Alain Vincent4Michèle Crozatier5Centre de Biologie du Développement, UMR 5547 CNRS/Université Toulouse III and Fédération de Recherche de Biologie de ToulouseCentre de Biologie du Développement, UMR 5547 CNRS/Université Toulouse III and Fédération de Recherche de Biologie de ToulouseCentre de Biologie du Développement, UMR 5547 CNRS/Université Toulouse III and Fédération de Recherche de Biologie de ToulouseCentre de Biologie du Développement, UMR 5547 CNRS/Université Toulouse III and Fédération de Recherche de Biologie de ToulouseCentre de Biologie du Développement, UMR 5547 CNRS/Université Toulouse III and Fédération de Recherche de Biologie de ToulouseCentre de Biologie du Développement, UMR 5547 CNRS/Université Toulouse III and Fédération de Recherche de Biologie de ToulouseThe posterior signalling centre (PSC) in Drosophilalarva regulates blood cell differentiation but it is unclear how this is controlled. Here, the authors show that Slit/Robo signalling from the vascular system regulates PSC morphology and function, in turn, regulating blood cell differentiation.https://doi.org/10.1038/ncomms11634
spellingShingle Ismaël Morin-Poulard
Anurag Sharma
Isabelle Louradour
Nathalie Vanzo
Alain Vincent
Michèle Crozatier
Vascular control of the Drosophila haematopoietic microenvironment by Slit/Robo signalling
Nature Communications
title Vascular control of the Drosophila haematopoietic microenvironment by Slit/Robo signalling
title_full Vascular control of the Drosophila haematopoietic microenvironment by Slit/Robo signalling
title_fullStr Vascular control of the Drosophila haematopoietic microenvironment by Slit/Robo signalling
title_full_unstemmed Vascular control of the Drosophila haematopoietic microenvironment by Slit/Robo signalling
title_short Vascular control of the Drosophila haematopoietic microenvironment by Slit/Robo signalling
title_sort vascular control of the drosophila haematopoietic microenvironment by slit robo signalling
url https://doi.org/10.1038/ncomms11634
work_keys_str_mv AT ismaelmorinpoulard vascularcontrolofthedrosophilahaematopoieticmicroenvironmentbyslitrobosignalling
AT anuragsharma vascularcontrolofthedrosophilahaematopoieticmicroenvironmentbyslitrobosignalling
AT isabellelouradour vascularcontrolofthedrosophilahaematopoieticmicroenvironmentbyslitrobosignalling
AT nathalievanzo vascularcontrolofthedrosophilahaematopoieticmicroenvironmentbyslitrobosignalling
AT alainvincent vascularcontrolofthedrosophilahaematopoieticmicroenvironmentbyslitrobosignalling
AT michelecrozatier vascularcontrolofthedrosophilahaematopoieticmicroenvironmentbyslitrobosignalling