Croton membranaceus Improves Some Biomarkers of Cardiovascular Disease and Diabetes in Genetic Animal Models
Introduction: Cardiovascular disease (CVD) accounts for 17.3 million deaths per year globally. In Ghana, CVD accounts for 22.2% of deaths. Croton membranaceus (CM) Mull. Arg. (Euphorbiaceae), a medicinal plant in Ghana is mainly used traditionally for the treatment of benign prostatic hyperplasi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/6899/14844_CE(RA1)_F(T)_PF1(EKAK)_PFA(P)_PF2(PAG).pdf |
| Summary: | Introduction: Cardiovascular disease (CVD) accounts for 17.3
million deaths per year globally. In Ghana, CVD accounts for 22.2%
of deaths. Croton membranaceus (CM) Mull. Arg. (Euphorbiaceae),
a medicinal plant in Ghana is mainly used traditionally for the
treatment of benign prostatic hyperplasia and measles. However,
some hypoglycaemic and hypotensive effects have recently been
reported but not scientifically examined.
Aim: The study aimed at establishing whether Croton
membranaceus (CM) used for prostatitis had any effect on CVD
markers.
Materials and Methods: In experiment 1, lipid profile changes
were determined. Twenty four male Spontaneously Hypertensive
Rats (SHR) were divided into 4 groups. Low (LD), intermediate (ID)
and high dose (HD) groups received 25, 50 and 100 mg/kg b.wt.
CM aqueous root extracts (CMARE) for 60 days, respectively, the
controls received distilled water. In experiment 2, blood glucose
levels (BGL) were determined. 21 db/db mice were divided into 3
groups of 7 mice each alongside db/+ mice (7) (negative control).
Groups 1 and 2 received 250 mg/kg b.wt CMARE and metformin,
respectively. Group 3 (positive control) and db/+ mice (negative
control) received distilled water. Mice were monitored for 15 hours.
Data collected were analysed using SPSS version 20.
Results: Hypotriglyceridaemic effect was observed (p=0.005).
High Density Lipoprotein cholesterol (HDL) and Low Density
Lipoprotein cholesterol (LDL) showed significant increases
(p=0.013) and decreases (p=0.003), respectively. A significant
CRP reduction was observed for ID and HD groups (p = 0.010, p
= 0.011, respectively). BGL was reduced in Metformin and Croton
groups (p=0.000; p= 0.006, respectively) after 3 hours.
Conclusion: In conclusion, CMARE has positive effects on some
CVD biomarkers and a hypoglycaemic effect. |
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| ISSN: | 2249-782X 0973-709X |