Croton membranaceus Improves Some Biomarkers of Cardiovascular Disease and Diabetes in Genetic Animal Models
Introduction: Cardiovascular disease (CVD) accounts for 17.3 million deaths per year globally. In Ghana, CVD accounts for 22.2% of deaths. Croton membranaceus (CM) Mull. Arg. (Euphorbiaceae), a medicinal plant in Ghana is mainly used traditionally for the treatment of benign prostatic hyperplasi...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2015-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/6899/14844_CE(RA1)_F(T)_PF1(EKAK)_PFA(P)_PF2(PAG).pdf |
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| author | George Awuku Asare Samuel Adjei Daniel Afriyie Akua Bempomaa Appiah-Danquah Jonas Asia Bernice Asiedu Sheila Santa Derek Doku |
| author_facet | George Awuku Asare Samuel Adjei Daniel Afriyie Akua Bempomaa Appiah-Danquah Jonas Asia Bernice Asiedu Sheila Santa Derek Doku |
| author_sort | George Awuku Asare |
| collection | DOAJ |
| description | Introduction: Cardiovascular disease (CVD) accounts for 17.3
million deaths per year globally. In Ghana, CVD accounts for 22.2%
of deaths. Croton membranaceus (CM) Mull. Arg. (Euphorbiaceae),
a medicinal plant in Ghana is mainly used traditionally for the
treatment of benign prostatic hyperplasia and measles. However,
some hypoglycaemic and hypotensive effects have recently been
reported but not scientifically examined.
Aim: The study aimed at establishing whether Croton
membranaceus (CM) used for prostatitis had any effect on CVD
markers.
Materials and Methods: In experiment 1, lipid profile changes
were determined. Twenty four male Spontaneously Hypertensive
Rats (SHR) were divided into 4 groups. Low (LD), intermediate (ID)
and high dose (HD) groups received 25, 50 and 100 mg/kg b.wt.
CM aqueous root extracts (CMARE) for 60 days, respectively, the
controls received distilled water. In experiment 2, blood glucose
levels (BGL) were determined. 21 db/db mice were divided into 3
groups of 7 mice each alongside db/+ mice (7) (negative control).
Groups 1 and 2 received 250 mg/kg b.wt CMARE and metformin,
respectively. Group 3 (positive control) and db/+ mice (negative
control) received distilled water. Mice were monitored for 15 hours.
Data collected were analysed using SPSS version 20.
Results: Hypotriglyceridaemic effect was observed (p=0.005).
High Density Lipoprotein cholesterol (HDL) and Low Density
Lipoprotein cholesterol (LDL) showed significant increases
(p=0.013) and decreases (p=0.003), respectively. A significant
CRP reduction was observed for ID and HD groups (p = 0.010, p
= 0.011, respectively). BGL was reduced in Metformin and Croton
groups (p=0.000; p= 0.006, respectively) after 3 hours.
Conclusion: In conclusion, CMARE has positive effects on some
CVD biomarkers and a hypoglycaemic effect. |
| first_indexed | 2024-12-12T13:12:54Z |
| format | Article |
| id | doaj.art-1c96c5a2887a40e5be9f2cf659a0b80f |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-12T13:12:54Z |
| publishDate | 2015-12-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-1c96c5a2887a40e5be9f2cf659a0b80f2022-12-22T00:23:28ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-12-01912OF01OF0510.7860/JCDR/2015/14844.6899Croton membranaceus Improves Some Biomarkers of Cardiovascular Disease and Diabetes in Genetic Animal ModelsGeorge Awuku Asare0Samuel Adjei1Daniel Afriyie2Akua Bempomaa Appiah-Danquah3Jonas Asia4Bernice Asiedu5Sheila Santa6Derek Doku7Faculty, Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, P.O. Box KB 143, Korle bu, Accra, Ghana. Faculty, Department of Animal Experimentation, Noguchi Memorial Institute for Medical Research (NMIMR), University of Ghana, Legon, Ghana. Faculty, Department of Pharmacy, Ghana Police Hospital, Cantonments, Accra, Ghana. Faculty, Department of Medical Laboratory Sciences School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, P.O. Box KB 143, Korle bu, Accra, Ghana.Faculty, Department of Medical Laboratory Sciences School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, P.O. Box KB 143, Korle bu, Accra, Ghana.Faculty, Department of Medical Laboratory Sciences School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, P.O. Box KB 143, Korle bu, Accra, Ghana.Faculty, Department of Medical Laboratory Sciences School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, P.O. Box KB 143, Korle bu, Accra, Ghana.Faculty, Department of Medical Laboratory Sciences School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, P.O. Box KB 143, Korle bu, Accra, Ghana.Introduction: Cardiovascular disease (CVD) accounts for 17.3 million deaths per year globally. In Ghana, CVD accounts for 22.2% of deaths. Croton membranaceus (CM) Mull. Arg. (Euphorbiaceae), a medicinal plant in Ghana is mainly used traditionally for the treatment of benign prostatic hyperplasia and measles. However, some hypoglycaemic and hypotensive effects have recently been reported but not scientifically examined. Aim: The study aimed at establishing whether Croton membranaceus (CM) used for prostatitis had any effect on CVD markers. Materials and Methods: In experiment 1, lipid profile changes were determined. Twenty four male Spontaneously Hypertensive Rats (SHR) were divided into 4 groups. Low (LD), intermediate (ID) and high dose (HD) groups received 25, 50 and 100 mg/kg b.wt. CM aqueous root extracts (CMARE) for 60 days, respectively, the controls received distilled water. In experiment 2, blood glucose levels (BGL) were determined. 21 db/db mice were divided into 3 groups of 7 mice each alongside db/+ mice (7) (negative control). Groups 1 and 2 received 250 mg/kg b.wt CMARE and metformin, respectively. Group 3 (positive control) and db/+ mice (negative control) received distilled water. Mice were monitored for 15 hours. Data collected were analysed using SPSS version 20. Results: Hypotriglyceridaemic effect was observed (p=0.005). High Density Lipoprotein cholesterol (HDL) and Low Density Lipoprotein cholesterol (LDL) showed significant increases (p=0.013) and decreases (p=0.003), respectively. A significant CRP reduction was observed for ID and HD groups (p = 0.010, p = 0.011, respectively). BGL was reduced in Metformin and Croton groups (p=0.000; p= 0.006, respectively) after 3 hours. Conclusion: In conclusion, CMARE has positive effects on some CVD biomarkers and a hypoglycaemic effect.https://jcdr.net/articles/PDF/6899/14844_CE(RA1)_F(T)_PF1(EKAK)_PFA(P)_PF2(PAG).pdfblood glucoseinflammationlipid profile |
| spellingShingle | George Awuku Asare Samuel Adjei Daniel Afriyie Akua Bempomaa Appiah-Danquah Jonas Asia Bernice Asiedu Sheila Santa Derek Doku Croton membranaceus Improves Some Biomarkers of Cardiovascular Disease and Diabetes in Genetic Animal Models Journal of Clinical and Diagnostic Research blood glucose inflammation lipid profile |
| title | Croton membranaceus Improves Some Biomarkers of Cardiovascular Disease and Diabetes in Genetic Animal Models |
| title_full | Croton membranaceus Improves Some Biomarkers of Cardiovascular Disease and Diabetes in Genetic Animal Models |
| title_fullStr | Croton membranaceus Improves Some Biomarkers of Cardiovascular Disease and Diabetes in Genetic Animal Models |
| title_full_unstemmed | Croton membranaceus Improves Some Biomarkers of Cardiovascular Disease and Diabetes in Genetic Animal Models |
| title_short | Croton membranaceus Improves Some Biomarkers of Cardiovascular Disease and Diabetes in Genetic Animal Models |
| title_sort | croton membranaceus improves some biomarkers of cardiovascular disease and diabetes in genetic animal models |
| topic | blood glucose inflammation lipid profile |
| url | https://jcdr.net/articles/PDF/6899/14844_CE(RA1)_F(T)_PF1(EKAK)_PFA(P)_PF2(PAG).pdf |
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