Traditional Cardiovascular Risk Factors and Coronary Collateral Circulation: A Meta-Analysis
Objective: Patients with well-developed coronary collateral circulation (CC) usually have low mortality, improved cardiac function, and reduced infarct size. Currently, there is conflicting evidence on the association between traditional cardiovascular risk factors (diabetes, hypertension, and smoki...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.743234/full |
| _version_ | 1818730050930868224 |
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| author | Junyu Pei Xiaopu Wang Zhenhua Xing Zhenhua Xing |
| author_facet | Junyu Pei Xiaopu Wang Zhenhua Xing Zhenhua Xing |
| author_sort | Junyu Pei |
| collection | DOAJ |
| description | Objective: Patients with well-developed coronary collateral circulation (CC) usually have low mortality, improved cardiac function, and reduced infarct size. Currently, there is conflicting evidence on the association between traditional cardiovascular risk factors (diabetes, hypertension, and smoking habit) and CC.Design: We performed a meta-analysis of case-control studies to better understand such associations.Data Sources: We searched the MEDINE, EMBASE, and Science Citation Index databases to identify relevant studies.Eligibility Criteria for Selecting Studies: Case control studies reporting data on risk factors (smoking habit, hypertension, and diabetes mellites) in comparing cases between poor CC and well-developed CC groups. Well-developed CC was the primary outcome of this meta-analysisData Extraction and Synthesis: Relevant data were extracted by two independent investigators. We derived pooled odds ratios (ORs) with random effects models. We performed quality assessments, publication bias, and sensitivity analysis to ensure the reliability of our results.Results: In total, 18 studies that had 4,746 enrolled patients were analyzed. Our results showed that hypertension and smoking habit did not (OR = 0.94, 95% CI: 0.75–1.17, p = 0.564 and OR = 1.00, 95% CI: 0.84–1.18, p = 0.970, respectively), and diabetes did (OR = 0.50, 95% CI: 0.38–0.67, p = 0.00001) affect the development of CC.Conclusion: Unlike hypertension and smoking habit, diabetes was associated with poor CC formation.Trial Registration Number:https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=87821, identifier: CRD42018087821. |
| first_indexed | 2024-12-17T22:55:38Z |
| format | Article |
| id | doaj.art-1c9819b39e2e41cd916bac15f21d811f |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-17T22:55:38Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-1c9819b39e2e41cd916bac15f21d811f2022-12-21T21:29:33ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-11-01810.3389/fcvm.2021.743234743234Traditional Cardiovascular Risk Factors and Coronary Collateral Circulation: A Meta-AnalysisJunyu Pei0Xiaopu Wang1Zhenhua Xing2Zhenhua Xing3Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, ChinaEmergency Medicine and Difficult Diseases Institute, Central South University, Changsha, ChinaObjective: Patients with well-developed coronary collateral circulation (CC) usually have low mortality, improved cardiac function, and reduced infarct size. Currently, there is conflicting evidence on the association between traditional cardiovascular risk factors (diabetes, hypertension, and smoking habit) and CC.Design: We performed a meta-analysis of case-control studies to better understand such associations.Data Sources: We searched the MEDINE, EMBASE, and Science Citation Index databases to identify relevant studies.Eligibility Criteria for Selecting Studies: Case control studies reporting data on risk factors (smoking habit, hypertension, and diabetes mellites) in comparing cases between poor CC and well-developed CC groups. Well-developed CC was the primary outcome of this meta-analysisData Extraction and Synthesis: Relevant data were extracted by two independent investigators. We derived pooled odds ratios (ORs) with random effects models. We performed quality assessments, publication bias, and sensitivity analysis to ensure the reliability of our results.Results: In total, 18 studies that had 4,746 enrolled patients were analyzed. Our results showed that hypertension and smoking habit did not (OR = 0.94, 95% CI: 0.75–1.17, p = 0.564 and OR = 1.00, 95% CI: 0.84–1.18, p = 0.970, respectively), and diabetes did (OR = 0.50, 95% CI: 0.38–0.67, p = 0.00001) affect the development of CC.Conclusion: Unlike hypertension and smoking habit, diabetes was associated with poor CC formation.Trial Registration Number:https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=87821, identifier: CRD42018087821.https://www.frontiersin.org/articles/10.3389/fcvm.2021.743234/fullcoronary collateral circulationsmoking habithypertensiondiabetesmeta-analysis |
| spellingShingle | Junyu Pei Xiaopu Wang Zhenhua Xing Zhenhua Xing Traditional Cardiovascular Risk Factors and Coronary Collateral Circulation: A Meta-Analysis Frontiers in Cardiovascular Medicine coronary collateral circulation smoking habit hypertension diabetes meta-analysis |
| title | Traditional Cardiovascular Risk Factors and Coronary Collateral Circulation: A Meta-Analysis |
| title_full | Traditional Cardiovascular Risk Factors and Coronary Collateral Circulation: A Meta-Analysis |
| title_fullStr | Traditional Cardiovascular Risk Factors and Coronary Collateral Circulation: A Meta-Analysis |
| title_full_unstemmed | Traditional Cardiovascular Risk Factors and Coronary Collateral Circulation: A Meta-Analysis |
| title_short | Traditional Cardiovascular Risk Factors and Coronary Collateral Circulation: A Meta-Analysis |
| title_sort | traditional cardiovascular risk factors and coronary collateral circulation a meta analysis |
| topic | coronary collateral circulation smoking habit hypertension diabetes meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.743234/full |
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