Reactive Oxygen Species and <i>H. pylori</i> Infection: A Comprehensive Review of Their Roles in Gastric Cancer Development
Gastric cancer (GC) is the fifth most common cancer worldwide and makes up a significant component of the global cancer burden. <i>Helicobacter pylori</i> (<i>H. pylori</i>) is the most influential risk factor for GC, with the International Agency for Research on Cancer class...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/9/1712 |
| _version_ | 1797581482894557184 |
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| author | Dhiraj Kumar Sah Archana Arjunan Bora Lee Young Do Jung |
| author_facet | Dhiraj Kumar Sah Archana Arjunan Bora Lee Young Do Jung |
| author_sort | Dhiraj Kumar Sah |
| collection | DOAJ |
| description | Gastric cancer (GC) is the fifth most common cancer worldwide and makes up a significant component of the global cancer burden. <i>Helicobacter pylori</i> (<i>H. pylori</i>) is the most influential risk factor for GC, with the International Agency for Research on Cancer classifying it as a Class I carcinogen for GC. <i>H. pylori</i> has been shown to persist in stomach acid for decades, causing damage to the stomach’s mucosal lining, altering gastric hormone release patterns, and potentially altering gastric function. Epidemiological studies have shown that eliminating <i>H. pylori</i> reduces metachronous cancer. Evidence shows that various molecular alterations are present in gastric cancer and precancerous lesions associated with an <i>H. pylori</i> infection. However, although <i>H. pylori</i> can cause oxidative stress-induced gastric cancer, with antioxidants potentially being a treatment for GC, the exact mechanism underlying GC etiology is not fully understood. This review provides an overview of recent research exploring the pathophysiology of <i>H. pylori</i>-induced oxidative stress that can cause cancer and the antioxidant supplements that can reduce or even eliminate GC occurrence. |
| first_indexed | 2024-03-10T23:06:08Z |
| format | Article |
| id | doaj.art-1c981f08a0cf4558ab34817be8bdc4f9 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T23:06:08Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-1c981f08a0cf4558ab34817be8bdc4f92023-11-19T09:19:22ZengMDPI AGAntioxidants2076-39212023-09-01129171210.3390/antiox12091712Reactive Oxygen Species and <i>H. pylori</i> Infection: A Comprehensive Review of Their Roles in Gastric Cancer DevelopmentDhiraj Kumar Sah0Archana Arjunan1Bora Lee2Young Do Jung3Department of Biochemistry, Chonnam National University Medical School, Seoyang Ro 264, Jeonnam, Hwasun 58128, Republic of KoreaDepartment of Biochemistry, Chonnam National University Medical School, Seoyang Ro 264, Jeonnam, Hwasun 58128, Republic of KoreaDepartment of Biochemistry, Chonnam National University Medical School, Seoyang Ro 264, Jeonnam, Hwasun 58128, Republic of KoreaDepartment of Biochemistry, Chonnam National University Medical School, Seoyang Ro 264, Jeonnam, Hwasun 58128, Republic of KoreaGastric cancer (GC) is the fifth most common cancer worldwide and makes up a significant component of the global cancer burden. <i>Helicobacter pylori</i> (<i>H. pylori</i>) is the most influential risk factor for GC, with the International Agency for Research on Cancer classifying it as a Class I carcinogen for GC. <i>H. pylori</i> has been shown to persist in stomach acid for decades, causing damage to the stomach’s mucosal lining, altering gastric hormone release patterns, and potentially altering gastric function. Epidemiological studies have shown that eliminating <i>H. pylori</i> reduces metachronous cancer. Evidence shows that various molecular alterations are present in gastric cancer and precancerous lesions associated with an <i>H. pylori</i> infection. However, although <i>H. pylori</i> can cause oxidative stress-induced gastric cancer, with antioxidants potentially being a treatment for GC, the exact mechanism underlying GC etiology is not fully understood. This review provides an overview of recent research exploring the pathophysiology of <i>H. pylori</i>-induced oxidative stress that can cause cancer and the antioxidant supplements that can reduce or even eliminate GC occurrence.https://www.mdpi.com/2076-3921/12/9/1712antioxidantsgastric cancer<i>Helicobacter pylori</i>inflammationoxidative stress |
| spellingShingle | Dhiraj Kumar Sah Archana Arjunan Bora Lee Young Do Jung Reactive Oxygen Species and <i>H. pylori</i> Infection: A Comprehensive Review of Their Roles in Gastric Cancer Development Antioxidants antioxidants gastric cancer <i>Helicobacter pylori</i> inflammation oxidative stress |
| title | Reactive Oxygen Species and <i>H. pylori</i> Infection: A Comprehensive Review of Their Roles in Gastric Cancer Development |
| title_full | Reactive Oxygen Species and <i>H. pylori</i> Infection: A Comprehensive Review of Their Roles in Gastric Cancer Development |
| title_fullStr | Reactive Oxygen Species and <i>H. pylori</i> Infection: A Comprehensive Review of Their Roles in Gastric Cancer Development |
| title_full_unstemmed | Reactive Oxygen Species and <i>H. pylori</i> Infection: A Comprehensive Review of Their Roles in Gastric Cancer Development |
| title_short | Reactive Oxygen Species and <i>H. pylori</i> Infection: A Comprehensive Review of Their Roles in Gastric Cancer Development |
| title_sort | reactive oxygen species and i h pylori i infection a comprehensive review of their roles in gastric cancer development |
| topic | antioxidants gastric cancer <i>Helicobacter pylori</i> inflammation oxidative stress |
| url | https://www.mdpi.com/2076-3921/12/9/1712 |
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