Waiting impulsivity in progressive supranuclear palsy-Richardson’s syndrome
BackgroundWaiting impulsivity in progressive supranuclear palsy-Richardson’s syndrome (PSP-RS) is difficult to assess, and its regulation is known to involve nucleus accumbens (NAc) subregions. We investigated waiting impulsivity using the “jumping the gun” (JTG) sign, which is defined as premature...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-09-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1240709/full |
| _version_ | 1797674044358656000 |
|---|---|
| author | Jong Hyeon Ahn Jong Hyeon Ahn Junmo Kwon Junmo Kwon Ji Hye Won Kyoungseob Byeon Kyoungseob Byeon Jinyoung Youn Jinyoung Youn Hyunjin Park Hyunjin Park Jin Whan Cho Jin Whan Cho |
| author_facet | Jong Hyeon Ahn Jong Hyeon Ahn Junmo Kwon Junmo Kwon Ji Hye Won Kyoungseob Byeon Kyoungseob Byeon Jinyoung Youn Jinyoung Youn Hyunjin Park Hyunjin Park Jin Whan Cho Jin Whan Cho |
| author_sort | Jong Hyeon Ahn |
| collection | DOAJ |
| description | BackgroundWaiting impulsivity in progressive supranuclear palsy-Richardson’s syndrome (PSP-RS) is difficult to assess, and its regulation is known to involve nucleus accumbens (NAc) subregions. We investigated waiting impulsivity using the “jumping the gun” (JTG) sign, which is defined as premature initiation of clapping before the start signal in the three-clap test and compared clinical features of PSP-RS patients with and without the sign and analyzed neural connectivity and microstructural changes in NAc subregions.Materials and methodsA positive JTG sign was defined as the participant starting to clap before the start sign in the three-clap test. We classified participants into the JTG positive (JTG +) and JTG negative (JTG-) groups and compared their clinical features, microstructural changes, and connectivity between NAc subregions using diffusion tension imaging. The NAc was parcellated into core and shell subregions using data-driven connectivity-based methods.ResultsSeventy-seven patients with PSP-RS were recruited, and the JTG + group had worse frontal lobe battery (FAB) scores, more frequent falls, and more occurrence of the applause sign than the JTG- group. A logistic regression analysis revealed that FAB scores were associated with a positive JTG sign. The mean fiber density between the right NAc core and right medial orbitofrontal gyrus was higher in the JTG + group than the JTG- group.DiscussionWe show that the JTG sign is a surrogate marker of waiting impulsivity in PSP-RS patients. Our findings enrich the current literature by deepening our understanding of waiting impulsivity in PSP patients and introducing a novel method for its evaluation. |
| first_indexed | 2024-03-11T21:54:25Z |
| format | Article |
| id | doaj.art-1c994b6117654ea3a0e223ac8139ecee |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-11T21:54:25Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-1c994b6117654ea3a0e223ac8139ecee2023-09-26T05:04:41ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-09-011710.3389/fnins.2023.12407091240709Waiting impulsivity in progressive supranuclear palsy-Richardson’s syndromeJong Hyeon Ahn0Jong Hyeon Ahn1Junmo Kwon2Junmo Kwon3Ji Hye Won4Kyoungseob Byeon5Kyoungseob Byeon6Jinyoung Youn7Jinyoung Youn8Hyunjin Park9Hyunjin Park10Jin Whan Cho11Jin Whan Cho12Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaNeuroscience Center, Samsung Medical Center, Seoul, Republic of KoreaDepartment of Electrical and Computer Engineering, Sungkyunkwan University, Suwon-si, Republic of KoreaCenter for Neuroscience Imaging Research, Institute for Basic Science, Suwon-si, Republic of KoreaDepartment of Computer Engineering, Pukyong National University, Busan, Republic of KoreaDepartment of Electrical and Computer Engineering, Sungkyunkwan University, Suwon-si, Republic of KoreaCenter for Neuroscience Imaging Research, Institute for Basic Science, Suwon-si, Republic of KoreaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaNeuroscience Center, Samsung Medical Center, Seoul, Republic of KoreaDepartment of Electrical and Computer Engineering, Sungkyunkwan University, Suwon-si, Republic of KoreaCenter for Neuroscience Imaging Research, Institute for Basic Science, Suwon-si, Republic of KoreaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaNeuroscience Center, Samsung Medical Center, Seoul, Republic of KoreaBackgroundWaiting impulsivity in progressive supranuclear palsy-Richardson’s syndrome (PSP-RS) is difficult to assess, and its regulation is known to involve nucleus accumbens (NAc) subregions. We investigated waiting impulsivity using the “jumping the gun” (JTG) sign, which is defined as premature initiation of clapping before the start signal in the three-clap test and compared clinical features of PSP-RS patients with and without the sign and analyzed neural connectivity and microstructural changes in NAc subregions.Materials and methodsA positive JTG sign was defined as the participant starting to clap before the start sign in the three-clap test. We classified participants into the JTG positive (JTG +) and JTG negative (JTG-) groups and compared their clinical features, microstructural changes, and connectivity between NAc subregions using diffusion tension imaging. The NAc was parcellated into core and shell subregions using data-driven connectivity-based methods.ResultsSeventy-seven patients with PSP-RS were recruited, and the JTG + group had worse frontal lobe battery (FAB) scores, more frequent falls, and more occurrence of the applause sign than the JTG- group. A logistic regression analysis revealed that FAB scores were associated with a positive JTG sign. The mean fiber density between the right NAc core and right medial orbitofrontal gyrus was higher in the JTG + group than the JTG- group.DiscussionWe show that the JTG sign is a surrogate marker of waiting impulsivity in PSP-RS patients. Our findings enrich the current literature by deepening our understanding of waiting impulsivity in PSP patients and introducing a novel method for its evaluation.https://www.frontiersin.org/articles/10.3389/fnins.2023.1240709/fullprogressive supranuclear palsywaiting impulsivityfrontal lobe dysfunctiondiffusion tensor imagingnucleus accumbens |
| spellingShingle | Jong Hyeon Ahn Jong Hyeon Ahn Junmo Kwon Junmo Kwon Ji Hye Won Kyoungseob Byeon Kyoungseob Byeon Jinyoung Youn Jinyoung Youn Hyunjin Park Hyunjin Park Jin Whan Cho Jin Whan Cho Waiting impulsivity in progressive supranuclear palsy-Richardson’s syndrome Frontiers in Neuroscience progressive supranuclear palsy waiting impulsivity frontal lobe dysfunction diffusion tensor imaging nucleus accumbens |
| title | Waiting impulsivity in progressive supranuclear palsy-Richardson’s syndrome |
| title_full | Waiting impulsivity in progressive supranuclear palsy-Richardson’s syndrome |
| title_fullStr | Waiting impulsivity in progressive supranuclear palsy-Richardson’s syndrome |
| title_full_unstemmed | Waiting impulsivity in progressive supranuclear palsy-Richardson’s syndrome |
| title_short | Waiting impulsivity in progressive supranuclear palsy-Richardson’s syndrome |
| title_sort | waiting impulsivity in progressive supranuclear palsy richardson s syndrome |
| topic | progressive supranuclear palsy waiting impulsivity frontal lobe dysfunction diffusion tensor imaging nucleus accumbens |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1240709/full |
| work_keys_str_mv | AT jonghyeonahn waitingimpulsivityinprogressivesupranuclearpalsyrichardsonssyndrome AT jonghyeonahn waitingimpulsivityinprogressivesupranuclearpalsyrichardsonssyndrome AT junmokwon waitingimpulsivityinprogressivesupranuclearpalsyrichardsonssyndrome AT junmokwon waitingimpulsivityinprogressivesupranuclearpalsyrichardsonssyndrome AT jihyewon waitingimpulsivityinprogressivesupranuclearpalsyrichardsonssyndrome AT kyoungseobbyeon waitingimpulsivityinprogressivesupranuclearpalsyrichardsonssyndrome AT kyoungseobbyeon waitingimpulsivityinprogressivesupranuclearpalsyrichardsonssyndrome AT jinyoungyoun waitingimpulsivityinprogressivesupranuclearpalsyrichardsonssyndrome AT jinyoungyoun waitingimpulsivityinprogressivesupranuclearpalsyrichardsonssyndrome AT hyunjinpark waitingimpulsivityinprogressivesupranuclearpalsyrichardsonssyndrome AT hyunjinpark waitingimpulsivityinprogressivesupranuclearpalsyrichardsonssyndrome AT jinwhancho waitingimpulsivityinprogressivesupranuclearpalsyrichardsonssyndrome AT jinwhancho waitingimpulsivityinprogressivesupranuclearpalsyrichardsonssyndrome |