Quantitative structure-activity relationship of the inhibitors of acetylcholinesterase by comparative molecular field analysis(乙酰胆碱酯酶抑制剂定量构效关系的比较分子场分析)
乙酸胆碱酯酶抑制剂是治疗早老性痴呆病的主要药物,为了给合成提供一些理论依据,可以利用3D-QSAR中的CoMFA方法研究乙酰胆碱酯酶抑制剂定量构效关系.研究表明,从PLS分析的rcv2,r2值看,模型有较强的预测能力;从立体与静电作用分数比看,立体因素占主要地位,对合成有一定的指导作用....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
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Zhejiang University Press
2003-03-01
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| Series: | Zhejiang Daxue xuebao. Lixue ban |
| Subjects: | |
| Online Access: | https://doi.org/zjup/1008-9497.2003.30.2.196-200 |
| _version_ | 1797236447756943360 |
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| author | ZHAOWen-na(赵文娜) HUANGMei-lan(黄美兰) ZHANGBing(张兵) ZOUJian-wei(邹建卫) SHANGZhi-cai(商志才) YUQing-sen(俞庆森) |
| author_facet | ZHAOWen-na(赵文娜) HUANGMei-lan(黄美兰) ZHANGBing(张兵) ZOUJian-wei(邹建卫) SHANGZhi-cai(商志才) YUQing-sen(俞庆森) |
| author_sort | ZHAOWen-na(赵文娜) |
| collection | DOAJ |
| description | 乙酸胆碱酯酶抑制剂是治疗早老性痴呆病的主要药物,为了给合成提供一些理论依据,可以利用3D-QSAR中的CoMFA方法研究乙酰胆碱酯酶抑制剂定量构效关系.研究表明,从PLS分析的rcv2,r2值看,模型有较强的预测能力;从立体与静电作用分数比看,立体因素占主要地位,对合成有一定的指导作用. |
| first_indexed | 2024-04-24T17:04:00Z |
| format | Article |
| id | doaj.art-1c996803fa1541929702152fc3c9d522 |
| institution | Directory Open Access Journal |
| issn | 1008-9497 |
| language | zho |
| last_indexed | 2024-04-24T17:04:00Z |
| publishDate | 2003-03-01 |
| publisher | Zhejiang University Press |
| record_format | Article |
| series | Zhejiang Daxue xuebao. Lixue ban |
| spelling | doaj.art-1c996803fa1541929702152fc3c9d5222024-03-29T01:58:19ZzhoZhejiang University PressZhejiang Daxue xuebao. Lixue ban1008-94972003-03-01302196200zjup/1008-9497.2003.30.2.196-200Quantitative structure-activity relationship of the inhibitors of acetylcholinesterase by comparative molecular field analysis(乙酰胆碱酯酶抑制剂定量构效关系的比较分子场分析)ZHAOWen-na(赵文娜)0HUANGMei-lan(黄美兰)1ZHANGBing(张兵)2ZOUJian-wei(邹建卫)3SHANGZhi-cai(商志才)4YUQing-sen(俞庆森)5Department of Chemistry, Zhejiang University, Hangzhou 310027, China(浙江大学化学系，浙江 杭州 310027)Department of Chemistry, Zhejiang University, Hangzhou 310027, China(浙江大学化学系，浙江 杭州 310027)Department of Chemistry, Zhejiang University, Hangzhou 310027, China(浙江大学化学系，浙江 杭州 310027)Department of Chemistry, Zhejiang University, Hangzhou 310027, China(浙江大学化学系，浙江 杭州 310027)Department of Chemistry, Zhejiang University, Hangzhou 310027, China(浙江大学化学系，浙江 杭州 310027)Department of Chemistry, Zhejiang University, Hangzhou 310027, China(浙江大学化学系，浙江 杭州 310027)乙酸胆碱酯酶抑制剂是治疗早老性痴呆病的主要药物,为了给合成提供一些理论依据,可以利用3D-QSAR中的CoMFA方法研究乙酰胆碱酯酶抑制剂定量构效关系.研究表明,从PLS分析的rcv2,r2值看,模型有较强的预测能力;从立体与静电作用分数比看,立体因素占主要地位,对合成有一定的指导作用.https://doi.org/zjup/1008-9497.2003.30.2.196-200乙酰胆碱酯酶抑制剂早老性痴呆比较分子场分析 |
| spellingShingle | ZHAOWen-na(赵文娜) HUANGMei-lan(黄美兰) ZHANGBing(张兵) ZOUJian-wei(邹建卫) SHANGZhi-cai(商志才) YUQing-sen(俞庆森) Quantitative structure-activity relationship of the inhibitors of acetylcholinesterase by comparative molecular field analysis(乙酰胆碱酯酶抑制剂定量构效关系的比较分子场分析) Zhejiang Daxue xuebao. Lixue ban 乙酰胆碱酯酶抑制剂 早老性痴呆 比较分子场分析 |
| title | Quantitative structure-activity relationship of the inhibitors of acetylcholinesterase by comparative molecular field analysis(乙酰胆碱酯酶抑制剂定量构效关系的比较分子场分析) |
| title_full | Quantitative structure-activity relationship of the inhibitors of acetylcholinesterase by comparative molecular field analysis(乙酰胆碱酯酶抑制剂定量构效关系的比较分子场分析) |
| title_fullStr | Quantitative structure-activity relationship of the inhibitors of acetylcholinesterase by comparative molecular field analysis(乙酰胆碱酯酶抑制剂定量构效关系的比较分子场分析) |
| title_full_unstemmed | Quantitative structure-activity relationship of the inhibitors of acetylcholinesterase by comparative molecular field analysis(乙酰胆碱酯酶抑制剂定量构效关系的比较分子场分析) |
| title_short | Quantitative structure-activity relationship of the inhibitors of acetylcholinesterase by comparative molecular field analysis(乙酰胆碱酯酶抑制剂定量构效关系的比较分子场分析) |
| title_sort | quantitative structure activity relationship of the inhibitors of acetylcholinesterase by comparative molecular field analysis 乙酰胆碱酯酶抑制剂定量构效关系的比较分子场分析 |
| topic | 乙酰胆碱酯酶抑制剂 早老性痴呆 比较分子场分析 |
| url | https://doi.org/zjup/1008-9497.2003.30.2.196-200 |
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