Quantitative structure-activity relationship of the inhibitors of acetylcholinesterase by comparative molecular field analysis(乙酰胆碱酯酶抑制剂定量构效关系的比较分子场分析)

Quantitative structure-activity relationship of the inhibitors of acetylcholinesterase by comparative molecular field analysis(乙酰胆碱酯酶抑制剂定量构效关系的比较分子场分析)

乙酸胆碱酯酶抑制剂是治疗早老性痴呆病的主要药物,为了给合成提供一些理论依据,可以利用3D-QSAR中的CoMFA方法研究乙酰胆碱酯酶抑制剂定量构效关系.研究表明,从PLS分析的rcv2,r2值看,模型有较强的预测能力;从立体与静电作用分数比看,立体因素占主要地位,对合成有一定的指导作用....

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Bibliographic Details
Main Authors: ZHAOWen-na(赵文娜), HUANGMei-lan(黄美兰), ZHANGBing(张兵), ZOUJian-wei(邹建卫), SHANGZhi-cai(商志才), YUQing-sen(俞庆森)
Format: Article
Language:zho
Published: Zhejiang University Press 2003-03-01
Series:Zhejiang Daxue xuebao. Lixue ban
Subjects:
乙酰胆碱酯酶抑制剂
早老性痴呆
比较分子场分析
Online Access:https://doi.org/zjup/1008-9497.2003.30.2.196-200

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