Abscopal effect of high-dose-rate brachytherapy on pelvic bone metastases from renal cell carcinoma: a case report
Radiation therapy is considered an optimal partner for immunotherapies. Several pre-clinical studies have demonstrated that regression of distant metastases, at remote non-irradiated sites of the body, termed the “abscopal effect”, can be achieved by an appropriate timing and combination of radiatio...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2019-10-01
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| Series: | Journal of Contemporary Brachytherapy |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Abscopal-effect-of-high-dose-rate-brachytherapy-on-pelvic-bone-metastases-from-renal-cell-carcinoma-a-case-report,54,38440,1,1.html |
| _version_ | 1818490403613048832 |
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| author | Gen Suzuki Koji Masui Hideya Yamazaki Tadashi Takenaka Syunsuke Asai Hidefumi Taniguchi Terukazu Nakamura Osamu Ukimura Kei Yamada |
| author_facet | Gen Suzuki Koji Masui Hideya Yamazaki Tadashi Takenaka Syunsuke Asai Hidefumi Taniguchi Terukazu Nakamura Osamu Ukimura Kei Yamada |
| author_sort | Gen Suzuki |
| collection | DOAJ |
| description | Radiation therapy is considered an optimal partner for immunotherapies. Several pre-clinical studies have demonstrated that regression of distant metastases, at remote non-irradiated sites of the body, termed the “abscopal effect”, can be achieved by an appropriate timing and combination of radiation with immunotherapy. However, nearly all pre-clinical and clinical studies evaluating a combination of radiation and immunotherapies have used external beam radiation therapy. We present in this case report, the abscopal effect observed in a 30-year-old Japanese woman with metastatic renal cell carcinoma after the treatment with high-dose-rate interstitial brachytherapy combined with nivolumab. This is the first published report demonstrating an abscopal effect following brachytherapy for human malignancy. Our case indicates that immuno-oncology effects are not limited to external beam irradiation regimens as they can also be attained by brachytherapy. |
| first_indexed | 2024-12-10T17:16:28Z |
| format | Article |
| id | doaj.art-1c9a6a2add554a9c9a98ee538f475c3e |
| institution | Directory Open Access Journal |
| issn | 1689-832X 2081-2841 |
| language | English |
| last_indexed | 2024-12-10T17:16:28Z |
| publishDate | 2019-10-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Journal of Contemporary Brachytherapy |
| spelling | doaj.art-1c9a6a2add554a9c9a98ee538f475c3e2022-12-22T01:40:06ZengTermedia Publishing HouseJournal of Contemporary Brachytherapy1689-832X2081-28412019-10-0111545846110.5114/jcb.2019.8936538440Abscopal effect of high-dose-rate brachytherapy on pelvic bone metastases from renal cell carcinoma: a case reportGen SuzukiKoji MasuiHideya YamazakiTadashi TakenakaSyunsuke AsaiHidefumi TaniguchiTerukazu NakamuraOsamu UkimuraKei YamadaRadiation therapy is considered an optimal partner for immunotherapies. Several pre-clinical studies have demonstrated that regression of distant metastases, at remote non-irradiated sites of the body, termed the “abscopal effect”, can be achieved by an appropriate timing and combination of radiation with immunotherapy. However, nearly all pre-clinical and clinical studies evaluating a combination of radiation and immunotherapies have used external beam radiation therapy. We present in this case report, the abscopal effect observed in a 30-year-old Japanese woman with metastatic renal cell carcinoma after the treatment with high-dose-rate interstitial brachytherapy combined with nivolumab. This is the first published report demonstrating an abscopal effect following brachytherapy for human malignancy. Our case indicates that immuno-oncology effects are not limited to external beam irradiation regimens as they can also be attained by brachytherapy.https://www.termedia.pl/Abscopal-effect-of-high-dose-rate-brachytherapy-on-pelvic-bone-metastases-from-renal-cell-carcinoma-a-case-report,54,38440,1,1.htmlbrachytherapy immunotherapy metastatic renal cell carcinoma nivolumab radiation abscopal effect |
| spellingShingle | Gen Suzuki Koji Masui Hideya Yamazaki Tadashi Takenaka Syunsuke Asai Hidefumi Taniguchi Terukazu Nakamura Osamu Ukimura Kei Yamada Abscopal effect of high-dose-rate brachytherapy on pelvic bone metastases from renal cell carcinoma: a case report Journal of Contemporary Brachytherapy brachytherapy immunotherapy metastatic renal cell carcinoma nivolumab radiation abscopal effect |
| title | Abscopal effect of high-dose-rate brachytherapy on pelvic bone metastases from renal cell carcinoma: a case report |
| title_full | Abscopal effect of high-dose-rate brachytherapy on pelvic bone metastases from renal cell carcinoma: a case report |
| title_fullStr | Abscopal effect of high-dose-rate brachytherapy on pelvic bone metastases from renal cell carcinoma: a case report |
| title_full_unstemmed | Abscopal effect of high-dose-rate brachytherapy on pelvic bone metastases from renal cell carcinoma: a case report |
| title_short | Abscopal effect of high-dose-rate brachytherapy on pelvic bone metastases from renal cell carcinoma: a case report |
| title_sort | abscopal effect of high dose rate brachytherapy on pelvic bone metastases from renal cell carcinoma a case report |
| topic | brachytherapy immunotherapy metastatic renal cell carcinoma nivolumab radiation abscopal effect |
| url | https://www.termedia.pl/Abscopal-effect-of-high-dose-rate-brachytherapy-on-pelvic-bone-metastases-from-renal-cell-carcinoma-a-case-report,54,38440,1,1.html |
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