Chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centers
Abstract Sensitive differentiation of an enantiomer from its mirror image (ie, enantiodifferentiation), a perennial challenge for pharmaceutical production and disease diagnosis, is technically limited by the weak optical activity (OA) of enantiomers, mainly due to their dimensional mismatch with li...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-11-01
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| Series: | InfoMat |
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| Online Access: | https://doi.org/10.1002/inf2.12091 |
| _version_ | 1818690707057016832 |
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| author | Lin Yang Junjun Liu Junhong Deng Zhifeng Huang |
| author_facet | Lin Yang Junjun Liu Junhong Deng Zhifeng Huang |
| author_sort | Lin Yang |
| collection | DOAJ |
| description | Abstract Sensitive differentiation of an enantiomer from its mirror image (ie, enantiodifferentiation), a perennial challenge for pharmaceutical production and disease diagnosis, is technically limited by the weak optical activity (OA) of enantiomers, mainly due to their dimensional mismatch with light wavelengths in the ultraviolet (UV)‐visible region. Here we use silver chiral nanoparticles (Ag CNPs) with nominally sub‐5 nm helical pitch (P) to amplify the OA of (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salts (RP), which have been found to indirectly affect metabolic processes, through the formation of an RP thin film (TF) covering a close‐packed array of Ag CNPs. The OA of the RP in the deep‐UV region can be amplified up to 80‐fold, ascribed to the aggregation of RP in the TFs and the interactions between RP and the atomically chiral lattices at the CNPs' surfaces. The former contribution, not associated with the chiral Ag topographies, plays a dominant role by thickening the RP TFs, so that the observed amplification has no enantioselective dependence on the chirality of the Ag CNPs. This study extends progress in the sensitive detection of bio‐enantiomers, which is highly desired for advanced bio‐detection in disease diagnosis and production of single‐enantiomer pharmaceuticals. |
| first_indexed | 2024-12-17T12:30:16Z |
| format | Article |
| id | doaj.art-1c9bc90dbec8499b99c60d313623f7af |
| institution | Directory Open Access Journal |
| issn | 2567-3165 |
| language | English |
| last_indexed | 2024-12-17T12:30:16Z |
| publishDate | 2020-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | InfoMat |
| spelling | doaj.art-1c9bc90dbec8499b99c60d313623f7af2022-12-21T21:48:36ZengWileyInfoMat2567-31652020-11-01261216122410.1002/inf2.12091Chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centersLin Yang0Junjun Liu1Junhong Deng2Zhifeng Huang3Department of Physics Hong Kong Baptist University (HKBU) Hong Kong ChinaDepartment of Physics Hong Kong Baptist University (HKBU) Hong Kong ChinaDepartment of Materials Science and Engineering, Southern University of Science and Technology Shenzhen Institute for Quantum Science and Engineering Shenzhen ChinaDepartment of Physics Hong Kong Baptist University (HKBU) Hong Kong ChinaAbstract Sensitive differentiation of an enantiomer from its mirror image (ie, enantiodifferentiation), a perennial challenge for pharmaceutical production and disease diagnosis, is technically limited by the weak optical activity (OA) of enantiomers, mainly due to their dimensional mismatch with light wavelengths in the ultraviolet (UV)‐visible region. Here we use silver chiral nanoparticles (Ag CNPs) with nominally sub‐5 nm helical pitch (P) to amplify the OA of (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salts (RP), which have been found to indirectly affect metabolic processes, through the formation of an RP thin film (TF) covering a close‐packed array of Ag CNPs. The OA of the RP in the deep‐UV region can be amplified up to 80‐fold, ascribed to the aggregation of RP in the TFs and the interactions between RP and the atomically chiral lattices at the CNPs' surfaces. The former contribution, not associated with the chiral Ag topographies, plays a dominant role by thickening the RP TFs, so that the observed amplification has no enantioselective dependence on the chirality of the Ag CNPs. This study extends progress in the sensitive detection of bio‐enantiomers, which is highly desired for advanced bio‐detection in disease diagnosis and production of single‐enantiomer pharmaceuticals.https://doi.org/10.1002/inf2.12091(2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium saltchiral nanoparticlescircular dichroismglancing angle depositionoptical activity |
| spellingShingle | Lin Yang Junjun Liu Junhong Deng Zhifeng Huang Chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centers InfoMat (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salt chiral nanoparticles circular dichroism glancing angle deposition optical activity |
| title | Chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centers |
| title_full | Chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centers |
| title_fullStr | Chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centers |
| title_full_unstemmed | Chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centers |
| title_short | Chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centers |
| title_sort | chiral nanoparticle induced amplification in optical activity of molecules with chiral centers |
| topic | (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salt chiral nanoparticles circular dichroism glancing angle deposition optical activity |
| url | https://doi.org/10.1002/inf2.12091 |
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