Correlation of plasma adipokines with endometrial atypical hyperplasia and type I/II endometrial cancer
The aim of the study was to systematically explore the relationships between various adipokines and risks of endometrial atypical hyperplasia (EAH), type I endometrial cancer (EC), and type II EC. We enrolled 219 patients in this study, including 39 EAH, 87 type I EC, 38 type II EC and 55 control in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Journal of Obstetrics and Gynaecology |
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| Online Access: | http://dx.doi.org/10.1080/01443615.2023.2179914 |
| _version_ | 1797685652834222080 |
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| author | Xinxin Zhu Linzhi Liu Zonghao Feng Yan Zhang |
| author_facet | Xinxin Zhu Linzhi Liu Zonghao Feng Yan Zhang |
| author_sort | Xinxin Zhu |
| collection | DOAJ |
| description | The aim of the study was to systematically explore the relationships between various adipokines and risks of endometrial atypical hyperplasia (EAH), type I endometrial cancer (EC), and type II EC. We enrolled 219 patients in this study, including 39 EAH, 87 type I EC, 38 type II EC and 55 control individuals. We subsequently explored the association of adipokine levels and the leptin-to-adiponectin (L/A) ratio with EAH, type I EC, and type II EC. The plasma leptin level and L/A ratio were significantly higher in the EAH group than in the control group (p = 0.012). Leptin, resistin, vaspin, and visfatin levels were significantly higher in the type I EC group; however, the adiponectin level was lower in the type I EC, which resulted in a higher L/A ratio. Notably, the L/A ratio and visfatin level in the type II EC group were significantly higher. Multiple logistic regression analysis revealed that a higher leptin level was significantly associated with a higher EAH risk (p = 0.012). Higher leptin level (p = 0.042) and L/A ratio (p = 0.027) were significantly associated with an increased type I EC risk. By contrast, higher leptin (p = 0.059) and visfatin (p = 0.003) levels, higher L/A ratio (p = 0.033), and lower adiponectin level (p = 0.042) were associated with an increased type II EC risk. We suggested that adipokines are potentially correlated with EAH and EC risks. |
| first_indexed | 2024-03-12T00:47:47Z |
| format | Article |
| id | doaj.art-1c9c546626dc400ab735331aa2547704 |
| institution | Directory Open Access Journal |
| issn | 0144-3615 1364-6893 |
| language | English |
| last_indexed | 2024-03-12T00:47:47Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Obstetrics and Gynaecology |
| spelling | doaj.art-1c9c546626dc400ab735331aa25477042023-09-14T15:29:13ZengTaylor & Francis GroupJournal of Obstetrics and Gynaecology0144-36151364-68932023-12-0143110.1080/01443615.2023.21799142179914Correlation of plasma adipokines with endometrial atypical hyperplasia and type I/II endometrial cancerXinxin Zhu0Linzhi Liu1Zonghao Feng2Yan Zhang3Department of Obstetrics and Gynecology, Peking University First HospitalDepartment of Obstetrics and Gynecology, Peking University First HospitalDepartment of Obstetrics and Gynecology, Peking University First HospitalDepartment of Obstetrics and Gynecology, Peking University First HospitalThe aim of the study was to systematically explore the relationships between various adipokines and risks of endometrial atypical hyperplasia (EAH), type I endometrial cancer (EC), and type II EC. We enrolled 219 patients in this study, including 39 EAH, 87 type I EC, 38 type II EC and 55 control individuals. We subsequently explored the association of adipokine levels and the leptin-to-adiponectin (L/A) ratio with EAH, type I EC, and type II EC. The plasma leptin level and L/A ratio were significantly higher in the EAH group than in the control group (p = 0.012). Leptin, resistin, vaspin, and visfatin levels were significantly higher in the type I EC group; however, the adiponectin level was lower in the type I EC, which resulted in a higher L/A ratio. Notably, the L/A ratio and visfatin level in the type II EC group were significantly higher. Multiple logistic regression analysis revealed that a higher leptin level was significantly associated with a higher EAH risk (p = 0.012). Higher leptin level (p = 0.042) and L/A ratio (p = 0.027) were significantly associated with an increased type I EC risk. By contrast, higher leptin (p = 0.059) and visfatin (p = 0.003) levels, higher L/A ratio (p = 0.033), and lower adiponectin level (p = 0.042) were associated with an increased type II EC risk. We suggested that adipokines are potentially correlated with EAH and EC risks.http://dx.doi.org/10.1080/01443615.2023.2179914adipokineendometrial atypical hyperplasiatype i endometrial cancertype ii endometrial cancerinsulin resistancerisk factor |
| spellingShingle | Xinxin Zhu Linzhi Liu Zonghao Feng Yan Zhang Correlation of plasma adipokines with endometrial atypical hyperplasia and type I/II endometrial cancer Journal of Obstetrics and Gynaecology adipokine endometrial atypical hyperplasia type i endometrial cancer type ii endometrial cancer insulin resistance risk factor |
| title | Correlation of plasma adipokines with endometrial atypical hyperplasia and type I/II endometrial cancer |
| title_full | Correlation of plasma adipokines with endometrial atypical hyperplasia and type I/II endometrial cancer |
| title_fullStr | Correlation of plasma adipokines with endometrial atypical hyperplasia and type I/II endometrial cancer |
| title_full_unstemmed | Correlation of plasma adipokines with endometrial atypical hyperplasia and type I/II endometrial cancer |
| title_short | Correlation of plasma adipokines with endometrial atypical hyperplasia and type I/II endometrial cancer |
| title_sort | correlation of plasma adipokines with endometrial atypical hyperplasia and type i ii endometrial cancer |
| topic | adipokine endometrial atypical hyperplasia type i endometrial cancer type ii endometrial cancer insulin resistance risk factor |
| url | http://dx.doi.org/10.1080/01443615.2023.2179914 |
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